Multifunctional Nanotube–Mucoadhesive Poly(methyl vinyl ether‐co‐maleic acid)@Hydroxypropyl Methylcellulose Acetate Succinate Composite for Site‐Specific Oral Drug Delivery

Abstract

An advanced oral drug delivery system that can effectively deliver drugs with poor oral bioavailability is strongly desirable. Herein, a multifunctional nano-in-micro structured composite is developed by encapsulation of the mucoadhesive poly(methyl vinyl ether-co-maleic acid) modified halloysite nanotubes (HNTs) with the pH-responsive hydroxypropyl methylcellulose acetate succinate by the microfluidics to control the drug release, increase cell-particle interaction, and improve drug absorption. The microparticles show spherical shape, homogeneous particle size distribution (58 ± 1 µm), and pH-responsive dissolution behavior at pH > 6, and they prevent the premature release of curcumin in simulated pH conditions of the stomach and immediately release the curcumin in simulated pH conditions of the small intestine. The surface modification of HNT with mucoadhesive poly(methyl vinyl ether-co-maleic acid) significantly enhances its interactions with the intestinal Caco-2/HT29-MTX cells and the mouse small intestines, and increases the permeability of curcumin across the co-cultured Caco-2/HT29-MTX cell monolayers by about 13 times compared to the free curcumin. Therefore, the developed multifunctional nanotube-mucoadhesive poly(methyl vinyl ether-co-maleic acid)@hydroxypropyl methylcellulose acetate succinate composite is a promising oral drug delivery system for drugs with poor oral bioavailability.

In Vivo Positive Magnetic Resonance Imaging Applications of Poly(methyl vinyl ether-alt-maleic acid)-coated Ultra-small Paramagnetic Gadolinium Oxide Nanoparticles

“…In the present study, poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) was used as a surface-coating material because it is a hydrophilic and biodegradable polymer [26][27][28]. It has been widely used in applications involving internal cellular drug delivery [26], oral drug delivery [27], and cell encapsulation [28]. PMVEMA has two carboxyl groups per monomer unit and consequently, numerous carboxyl groups per polymer.…”

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

“…51 Functionalisation of HNTs with mucoadhesive polymers enhances their interactions with intestinal cells and causes no cytotoxicity. 52 Topical administration of HNT coatings on hair surfaces was recently proposed. Inclusion of selected dyes or drugs into HNTs prior to their application allows for hair coloring or medical treatment, respectively.…”

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

“…After demonstrating the ROS‐responsive release of the payload, in vitro and in vivo studies with a specific model that mimics the GIT, or the IBD should be performed. For example, in vitro , the intestinal membranes can be simulated with a co‐cultured monolayer model, human colorectal adenocarcinoma cells Caco‐2 and mucus secreting intestinal epithelial cells HT29‐MTX, which form together TJs that mimic the in vivo intestinal epithelium to perform permeability studies.…”