Multifunctional Nature of Enterobacterial Fimbriae

Korhonen, Timo; Westerlund, Benita; Virkola, Ritva; Tarkkanen, A; Lähteenmäki, Kaarina; Kukkonen, Maini; Raunio, Tiina; Adegoke, G. O.; Miettinen, Aaro; Clegg, Steven

doi:10.1007/978-1-4615-3038-1_11

Molecular Recognition in Host-Parasite Interactions 1992

DOI: 10.1007/978-1-4615-3038-1_11

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Multifunctional Nature of Enterobacterial Fimbriae

Timo Korhonen

Benita Westerlund

Ritva Virkola

et al.

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1992

1994

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Cited by 2 publications

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“…1A). The immunological cross-reactivity of these E. coli fimbriae with SEF 17 of S. enteritidis was unexpected since serologically related fimbriae of these two genera of enteropathogens have not been previously detected (24). This finding raised the possibility that these fimbriae were also biochemically related and prompted our further investigation.…”

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Thin aggregative fimbriae from diarrheagenic Escherichia coli

et al. 1992

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Four strains of diarrheagenic Escherichia coli originally isolated from distinct geographic regions were found to produce unusual thin aggregative fimbriae requiring depolymerization in formic acid prior to analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Immunoelectron microscopy of native fimbriae and Western blot (immunoblot) analysis of the corresponding 18-kDa fimbrins showed that these E. coli fimbriae were serologically cross-reactive with SEF 17 (Salmonella enteritidis fimbriae with a fimbrin molecular mass of 17 kDa). The E. coli and S. enteritidis fimbrins had similar total amino acid compositions and highly conserved N-terminal amino acid sequences. These results indicate that E. coli and S. enteritidis produce biochemically related, aggregative fimbriae which constitute a new type of intergenerically distributed fimbriae for which we propose the descriptive name GVVPQ fimbriae on the basis of the conserved N-terminal amino acid sequence.Successful bacterial pathogens present to their susceptible host complex cell surfaces which contain components enabling the bacteria to initially associate with and subsequently adhere to specific host tissues (2, 21). The attachment of enteropathogens to gastrointestinal epithelial cells is presumed to be essential if these bacteria are to avoid host clearance mechanisms and compete with normal flora for appropriate niches (2, 15). However, the specific attachment mechanism(s) of many enteropathogens in vivo has not been clearly established (2,14).

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Thin aggregative fimbriae from diarrheagenic Escherichia coli

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What MakesEscherichia coliPathogenic?

Siitonen

1994

Annals of Medicine

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Multifunctional Nature of Enterobacterial Fimbriae

Cited by 2 publications

References 23 publications

Thin aggregative fimbriae from diarrheagenic Escherichia coli

Thin aggregative fimbriae from diarrheagenic Escherichia coli

What MakesEscherichia coliPathogenic?

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