Multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Fu, Shawei; Ding, Yadan; Cong, Tie; Yang, Xiaoguang; Xia, Hong; B, Yu; Li, Yuxin; Liu, Yichun

doi:10.1039/c9dt02329a

Cited by 15 publications

(4 citation statements)

References 51 publications

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“…3 Schematic illustration of the synthesis process of (a) Fe 3 O 4 @MIL-100(Fe)-UCNPs, 22 (b) UCNP-Pt(IV)-ZnFe 2 O 4 , 35 (c) Fe 3 O 4 @mSiO 2 /PDDA/BSA-Gd 2 O 3 , 80 and (d) SiO 2 @UCNP-Ce6-Fe(OH) 3 nanocomposites. 85 Fe 3+ on the surface of Fe-based nanoparticles due to strong coordination. The uncoordinated positive charge could further attract 1,3,5-benzenetricarboxylic acid (H 3 BTC) and an organic framework was assembled.…”

Section: Heterostructures By Chemical Bond Connectionmentioning

confidence: 99%

“…However, the regulation of the Fe 3 O 4 concentration had weak influence on the relaxation capacity of adjacent water protons. Hong 85 and Liu 86 synthesized magnetic luminescent nanocomposites dominated by electrostatic layer-by-layer adsorption. Liu first prepared DA-modified Fe 3 O 4 and poly(acrylic acid)(PAA)-coated UCNPs:Yb/Er, separately.…”

Section: Compound Strategiesmentioning

confidence: 99%

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The development of rare-earth combined Fe-based magnetic nanocomposites for use in biological theranostics

et al. 2023

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Section: Heterostructures By Chemical Bond Connectionmentioning

confidence: 99%

Section: Compound Strategiesmentioning

confidence: 99%

The development of rare-earth combined Fe-based magnetic nanocomposites for use in biological theranostics

et al. 2023

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“…Li et al synthesized biomimetic immuno-uorescent magnetic multifunctional nanoprobes for isolation and analysis of tumor cell subpopulations [8]. Fu et al synthesized multifunctional NaYF 4 :Yb,Er@PE 3 @Fe 3 O 4 nanocomposites for magnetic-eld-assisted upconversion imaging guided photothermal therapy of cancer cells [9].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning synthesis of Fe3O4/Eu(DBM)3phen/PVP multifunctional microfibers and their structure, luminescent and magnetic properties

Qin

Liu

2021

J Mater Sci: Mater Electron

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Multifunctional Fe 3 O 4 /Eu(DBM) 3 phen/PVP ((DBM: dibenzoylmethane, phen: 1,10-phenanthroline, PVP: polyvinyl pyrrolidone) micro bers were constructed by simple electrospinning process. The structure and morphology of the micro bers were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images. The diameters of pure PVP micro bers and the micro bers doped only with Fe 3 O 4 nanoparticles (NPs) were uniformly distributed, with an average size of about 360 nm. When 3% Eu(DBM) 3 phen complex and Fe 3 O 4 NPs were both added to the precursor for electrospinning, the micro bers became very inhomogeneous in diameter. The photoluminescent properties of pure Eu(DBM) 3 phen complex and composite micro bers were also studied. The characteristic emission peaks of Eu 3+ appeared in the composite micro bers. The intensities of emission and excitation spectra gradually decrease with adding more Fe 3 O 4 NPs. The unit mass of the pure europium complex in some composite micro bers gave stronger luminescence than the pure europium complex. The uorescence lifetime of 5 D 0 state in the composite micro bers is longer than that of pure europium complex. Additionally, the magnetic properties of Fe 3 O 4 NPs and the composite micro bers were investigated. Fe 3 O 4 NPs and composite micro bers were both superparamagnetic. The saturation magnetization of the composite micro bers was smaller than that of pure Fe 3 O 4 NPs.

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“…In recent years, multifunctional nanocomposite materials have attracted extensive interest because they can integrate multiple functionalities into one single nanosystem and thus endow them with great potential application in various areas (Gao et al, 2009 ; Liu Z. et al, 2011 ; Cheng et al, 2013 ; Jia et al, 2019 ; Sun et al, 2019 ; Liao et al, 2020 ). Among them, nanoparticles (NPs) with magnetism and luminescence have been extensively studied for their applications in biomedicine, for example, targeted enrichment and separation, magnetic targeted drug delivery, magnetic resonance imaging (MRI), biological luminescent probes (Cheng et al, 2016 ; Chen and Fu, 2018 ; Ding et al, 2018 ; Tang et al, 2018 ; Wang et al, 2018 ; Fu et al, 2019 ). Rare-earth doped upconversion luminescent nanomaterials (UCNPs) can emit high-energy photons of different wavelengths in visible or near-infrared (NIR) region by absorbing two or more low-energy photons in NIR region, this makes UCNPs have the prominent advantages over traditional phosphors in low autofluorescence background, shape emission bandwidths, good photochemical stability, and large tissue penetration depth (Xu et al, 2018 ; Zhu et al, 2018 ; Zhang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging

et al. 2020

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Multifunctional nanocomposites can combine multiple functions into a single nanosystem and thus have attracted extensive interest in various fields. The combination of magnetic and upconversion luminescent nanoparticles into one single nanoplatform, which have a good application in biomedical fields such as bio-magnetic separation, magnetic resonance imaging (MRI), and optical imaging, is highly desirable. Here we reported multifunctional nanocomposites by using hollow carbon sphere to integrate magnetic Fe 3 O 4 and upconversion nanoparticles (UCNPs) into one nanosystem. The as-prepared UCNPs/Fe 3 O 4 @h-C have near-infrared (NIR) luminescence under 980 nm excitation and superparamagnetism. In addition, since the carbon layer can absorb NIR light and transfer it into heat with high efficiency, the nanocomposites can realize photo thermal (PT), upconversion luminescence (UCL) and MRI tri-mode imaging. The UCNPs/Fe 3 O 4 @h-C might be further utilized as a potential theranostic agent, including its in-depth monitoring through luminescent imaging and MRI diagnosis, as well as its direct use in tumors as a photothermal therapy (PTT) agent.

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Multifunctional NaYF₄:Yb,Er@PE₃@Fe₃O₄ nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Abstract: Magnetic-field-assisted sensitive upconversion luminescence imaging and enhanced photothermal therapeutic efficacy were achieved with multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites.

Cited by 15 publications

References 51 publications

The development of rare-earth combined Fe-based magnetic nanocomposites for use in biological theranostics

The development of rare-earth combined Fe-based magnetic nanocomposites for use in biological theranostics

Electrospinning synthesis of Fe3O4/Eu(DBM)3phen/PVP multifunctional microfibers and their structure, luminescent and magnetic properties

Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging

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