Multifunctional Polymeric Micelles for Cancer Therapy

Jin, Geun-Woo; Rejinold, N. Sanoj

doi:10.3390/polym14224839

Cited by 32 publications

(15 citation statements)

References 76 publications

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“…3. Drug distribution to the intracellular organelles of the target cells is known as third order targeting (intercellular organelles targeting) [ 64 ].…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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“…3. Drug distribution to the intracellular organelles of the target cells is known as third order targeting (intercellular organelles targeting) [ 64 ].…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…In addition, PMs cannot modify the drug release and concentrate it on targeted cancerous sites [ 126 ]. Due to their size in the nanometric range, they are prone to accumulate in the microenvironment of cancer through EPR [ 127 , 128 ].…”

Section: Nanocarrier-based Codelivery Of Chemotherapeutic Agent With ...mentioning

confidence: 99%

Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers

et al. 2023

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Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various hurdles, such as drug resistance, insensitivity of cancer cells to drugs, adverse effects and patient inconveniences. Hence, plant-based phytochemicals could be a better substitute for conventional chemotherapy for treatment of cancer due to various properties: lesser adverse effects, action via multiple pathways, economical, etc. Various preclinical studies have demonstrated that a combination of phytochemicals with conventional anticancer drugs is more efficacious than phytochemicals individually to treat cancer because plant-derived compounds have lower anticancer efficacy than conventional anticancer drugs. Moreover, phytochemicals suffer from poor aqueous solubility and reduced bioavailability, which must be resolved for efficacious treatment of cancer. Therefore, nanotechnology-based novel carriers are employed for codelivery of phytochemicals and conventional anticancer drugs for better treatment of cancer. These novel carriers include nanoemulsion, nanosuspension, nanostructured lipid carriers, solid lipid nanoparticles, polymeric nanoparticles, polymeric micelles, dendrimers, metallic nanoparticles, carbon nanotubes that provide various benefits of improved solubility, reduced adverse effects, higher efficacy, reduced dose, improved dosing frequency, reduced drug resistance, improved bioavailability and higher patient compliance. This review summarizes various phytochemicals employed in treatment of cancer, combination therapy of phytochemicals with anticancer drugs and various nanotechnology-based carriers to deliver the combination therapy in treatment of cancer.

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“…22 In another study, DOX encapsulated poly(N-isopropylacrylamide)-block-poly(L-histidine) micelles have successfully targeted hepatocellular carcinoma therapy. 23 However, their clinical potential is limited as cationic polymers may interact with cell membranes, leading to toxicity. 24 Nanoemulsions consist of an aqueous phase, an emulsifying agent, and oil.…”

Section: Introductionmentioning

confidence: 99%

“…From this viewpoint, covalent bonding of the integrin-binding sequence peptides with the micelle has been used to actively target tumors . In another study, DOX encapsulated poly( N -isopropylacrylamide)-block-poly( l -histidine) micelles have successfully targeted hepatocellular carcinoma therapy . However, their clinical potential is limited as cationic polymers may interact with cell membranes, leading to toxicity .…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Design of Metal–Organic Frameworks for Cancer Theranostics: Current Challenges and Future Perspective

Pantwalawalkar,

Mhettar,

Nangare

et al. 2023

ACS Biomater. Sci. Eng.

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Scientific fraternity revealed the potential of stimuli-responsive nanotherapeutics for cancer treatment that aids in tackling the major restrictions of traditionally reported drug delivery systems. Among stimuli-responsive inorganic nanomaterials, metal–organic frameworks (MOFs) have transpired as unique porous materials displaying resilient structures and diverse applications in cancer theranostics. Mainly, it demonstrates tailorable porosity, versatile chemical configuration, tunable size and shape, and feasible surface functionalization, etc. The present review provides insights into the design of stimuli-responsive multifunctional MOFs for targeted drug delivery and bioimaging for effective cancer therapy. Initially, the concept of cancer, traditional cancer treatment, background of MOFs, and approaches for MOFs synthesis have been discussed. After this, applications of stimuli-responsive multifunctional MOFs-assisted nanostructures that include pH, light, ions, temperature, magnetic, redox, ATP, and others for targeted drug delivery and bioimaging in cancer have been thoroughly discussed. As an outcome, the designed multifunctional MOFs showed an alteration in properties due to the exogenous and endogenous stimuli that are beneficial for drug release and bioimaging. The several reported types of stimuli-responsive surface-modified MOFs revealed good biocompatibility to normal cells, promising drug loading capability, target-specific delivery of anticancer drugs into cancerous cells, etc. Despite substantial progress in this field, certain crucial issues need to be addressed to reap the clinical benefits of multifunctional MOFs. Specifically, the toxicological compatibility and biodegradability of the building blocks of MOFs demand a thorough evaluation. Moreover, the investigation of sustainable and greener synthesis methods is of the utmost importance. Also, the low flexibility, off-target accumulation, and compromised pharmacokinetic profile of stimuli-responsive MOFs have attracted keen attention. In conclusion, the surface-modified nanosized design of inorganic diverse stimuli-sensitive MOFs demonstrated great potential for targeted drug delivery and bioimaging in different kinds of cancers. In the future, the preference for stimuli-triggered MOFs will open a new frontier for cancer theranostic applications.

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Multifunctional Polymeric Micelles for Cancer Therapy

Cited by 32 publications

References 76 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers

Stimuli-Responsive Design of Metal–Organic Frameworks for Cancer Theranostics: Current Challenges and Future Perspective

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