gent wearable medical devices (IWMDs) has advanced rapidly, with research emphasis on physiological/pathological factors inducing biosensing and active delivery of therapeutic agents in an ondemand manner. [1] IWMDs constitute a vast array of wearable types, such as wrist bands, smart contact lenses, smart patches, and electronic textiles, which are used to measure biophysical or biochemical signals and, most recently, to achieve therapeutic interference by establishing microenvironmental detection-delivery feedback cycles. Accordingly, IWMDs have become critical components in achieving personalized healthcare and precision medicine. [2] Such devices can provide predictive bio-analysis and offer timely treatment intervention, improving drug efficacy, overcoming the potential dangers due to delayed treatment, and expanding the flexibility of drug use in time and space.For biodetection and monitoring, wearable biosensing devices (WBDs) have been developed to detect many physiological features such as mechanical deformations, electrocardiogram (ECG) signals, body temperature, [3][4][5] and biochemical components such as glucose, calcium ions, and lactate. [6][7][8] For a long time, efforts have been made to advance WBDs by tracking single analytes to multiple analytes. Previous reviews have described several types of representative wearable sensors for healthcare monitoring. [9] For drug delivery, transdermal/topical wearable delivery devices (WDDs) are advantageous over oral and injection delivery modalities in terms of flexibility and scalability and have been utilized to deliver therapeutic agents such as polypeptides, [10][11][12] polysaccharides, [13] small molecules, [14] and growth factors [15] continuously and responsively. Recent studies indicate that wearable transdermal patches constructed from responsive materials show great advantages and attractive prospects in application of WDDs. [16] Despite the considerable development of WBDs and WDDs, efforts are being made to combine them into a single system to provide both sensing and delivery services, for which IWMDs are expected to realize two core functions: identification of physiological/pathological markers and delivery of therapeutic agents. [17] As Figure 1 shows, IWMDs are defined as composite pieces of equipment that contain multiple subsystems, including embedded sensors, drug repositories, and their connecting attachments. In addition, some other components, The primary roles of precision medicine are to perform real-time examination, administer on-demand medication, and apply instruments continuously. However, most current therapeutic systems implement these processes separately, leading to treatment interruption and limited recovery in patients. Personalized healthcare and smart medical treatment have greatly promoted research on and development of biosensing and drug-delivery integrated systems, with intelligent wearable medical devices (IWMDs) as typical systems, which have received increasing attention because of their non-invasive and custom...