Multifunctional tadpole-like bimetallic nanoparticles realizes synergistic sterilization with chemical kinetics and photothermal therapy

Gao, Yumeng; Wang, Wentao; Zhang, Ming; Shen, Jian; Zhou, Ninglin

doi:10.1016/j.apcatb.2022.122314

Cited by 18 publications

(10 citation statements)

References 49 publications

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“…GSH, as a tripeptide with thiol groups, , is an important redox substance for maintaining metabolism and homeostasis in bacteria, significantly contributing to the bacterial pathogenicity . Therefore, the depletion of GSH to disrupt bacterial oxidative stress homeostasis is an effective strategy for the inactivation of bacteria.…”

Section: Resultsmentioning

confidence: 99%

Core–Shell NiS@SrTiO₃ Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Liu,

Ding,

et al. 2023

ACS Appl. Mater. Interfaces

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Developing bone implants with dynamic self-adjustment of antibacterial, angiogenic, and osteogenic functions in line with a bone regenerative cascade is highly required in orthopedics. Herein, a unique core–shell nanorods array featuring a thin layer of NiS coated on each SrTiO3 nanorod (NiS@SrTiO3) was in situ constructed on titanium (Ti) through a two-step hydrothermal treatment. Under near-infrared (NIR) irradiation, the photoresponsive effect of NiS layer in synergy with the physical perforation of SrTiO3 nanorods initially enabled in vitro antibacterial rates of 96.5% to Escherichia coli and 93.1% to Staphylococcus aureus. With the degradation of the NiS layer, trace amounts of Ni ions were released, which accelerated angiogenesis by upregulating the expression of vascular regeneration-related factors, while the gradual exposure of SrTiO3 nanorods could simultaneously enhance the surface hydrophilicity in favor of cell adhesion and slowly release Sr ions to promote the proliferation and differentiation of MC3T3-E1 cells. The in vivo assessment verified not only the satisfactory antibacterial effect but also the superior osteogenic ability of the NiS@SrTiO3/Ti group with the aid of NIR irradiation, finally promoting the osseointegration of the Ti implant. The modification method endowing Ti implant with antibacterial, angiogenic, and osteogenic functions provides a new strategy to improve the long-term reliability of Ti-based devices.

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Section: Resultsmentioning

confidence: 99%

Core–Shell NiS@SrTiO₃ Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Liu,

Ding,

et al. 2023

ACS Appl. Mater. Interfaces

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“…Bacterial infection is a common pathological condition at wound sites that would induce the innate immune response. Macrophages were typical immune cells in regulating the inflammation-related immune response process. , Macrophages were described into pro-inflammatory M1 subtype and anti-inflammatory M2 subtype. , M1 macrophages could induce inflammation in the early stages via secreting endogenous cytokines including cytokines of inflammation (TNF-α), and inducible nitric oxide synthase (iNOS), and it also produced ROS in mitochondria at infected sites. , The accumulation of pro-inflammatory cytokines and ROS would facilitate the generation of M1 macrophages, thus deteriorating the inflammation and inhibiting wound healing. In contrast, M2 macrophages could rescue excessive inflammation by secreting interleukin-10 (IL-10).…”

Section: Resultsmentioning

confidence: 99%

“…Macrophages were typical immune cells in regulating the inflammation-related immune response process. 15,48 Macrophages were described into pro-inflammatory M1 subtype and anti-inflammatory M2 subtype. 49,50 M1 macrophages could induce inflammation in the early stages via secreting endogenous cytokines including cytokines of inflammation (TNF-α), and inducible nitric oxide synthase (iNOS), and it also produced ROS in mitochondria at infected sites.…”

Section: ■ Introductionmentioning

confidence: 99%

Manganese–Iron Dual Single-Atom Catalyst with Enhanced Nanozyme Activity for Wound and Pustule Disinfection

Zhang,

Xu,

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Even though great progress has been achieved in mimicking natural enzyme engineering, few artificial enzymes with efficient catalytic performance and multifunction have been reported. In this study, novel manganese–iron dual single-atom catalysts (Mn/Fe SACs) were synthesized via a hydrothermal/pyrolysis recipe. Iron atoms inside the Mn/Fe SACs adequately exerted the peroxidase (POD)-like activity, its Michaelis–Menten constant, and maximum initial velocity superior to the horseradish peroxidase. Manganese atoms sufficiently catalyzed the H2O2 to generate oxygen (O2), which alleviated the challenge of the continued lack of O2 in the infected wound. In addition, Mn/Fe SACs possess a glutathione oxidase-like activity that further enhanced POD-like activity in the therapeutic process. The antibacterial rates of Mn/Fe SACs were 95 and 94.5% for Escherichia coli and Staphylococcus aureus, respectively. In vitro anti-inflammatory experiments demonstrated that Mn/Fe SACs could regulate the polarization of macrophages into the anti-inflammatory M2 subtype. In vivo wound healing experiments suggested that the combination therapy of Mn/Fe SACs and chemodynamic therapy presented a great promotion of the recovery rate. Moreover, the O2 generated by the catalase-like process contributed to the catalysts permeating the interior of the infected wounds and achieved preferable abscess elimination ability. This work revealed the potential of Mn/Fe SACs as broad-spectrum antimicrobial materials, which provided a novel strategy for treating infected and abscess wounds.

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“…[15][16][17] Therefore, introducing a nearinfrared (NIR) laser to convert light energy into thermal energy could further induce bacterial hyperthermia and death noninvasively and reinforce the generation of •OH to construct the nanozyme-photothermal antibacterial platform. [18][19][20] The synergistic nanozyme-photothermal strategy makes the therapeutic process highly controllable and avoids side effects on healthy tissues caused by relatively high-power laser intensity. [21][22][23] Herein, an ultra-thin two-dimensional PdMo bimetallene was prepared for efficient broad-spectrum sterilization applications.…”

Section: Introductionmentioning

confidence: 99%

PdMo bimetallene nanozymes for photothermally enhanced antibacterial therapy and accelerated wound healing

Zhou,

Li,

Wang

et al. 2024

Dalton Trans.

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Multifunctional tadpole-like bimetallic nanoparticles realizes synergistic sterilization with chemical kinetics and photothermal therapy

Cited by 18 publications

References 49 publications

Core–Shell NiS@SrTiO₃ Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Core–Shell NiS@SrTiO₃ Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Manganese–Iron Dual Single-Atom Catalyst with Enhanced Nanozyme Activity for Wound and Pustule Disinfection

PdMo bimetallene nanozymes for photothermally enhanced antibacterial therapy and accelerated wound healing

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Multifunctional tadpole-like bimetallic nanoparticles realizes synergistic sterilization with chemical kinetics and photothermal therapy

Cited by 18 publications

References 49 publications

Core–Shell NiS@SrTiO3 Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Core–Shell NiS@SrTiO3 Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Manganese–Iron Dual Single-Atom Catalyst with Enhanced Nanozyme Activity for Wound and Pustule Disinfection

PdMo bimetallene nanozymes for photothermally enhanced antibacterial therapy and accelerated wound healing

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Product

Resources

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Core–Shell NiS@SrTiO₃ Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis

Core–Shell NiS@SrTiO₃ Nanorods on Titanium for Enhanced Osseointegration via Programmed Regulation of Bacterial Infection, Angiogenesis, and Osteogenesis