Multifunctional ternary drug‐loaded electrospun scaffolds

Abstract

Multifunctional electrospun scaffolds were prepared from two PLA grades having slightly different D-lactide content (4.2 wt-% and 2.0 wt-%). Triclosan (TCS), ketoprofen (KTP) and p-coumaric acid (CUM) were selected as bactericide, antiinflammatory and antioxidant agents, respectively. Single, binary and ternary drugloaded microfibers having a unimodal diameter distribution could be prepared using a common chloroform:acetone:dimethylsulfoxide mixture and similar operational parameters (i.e. voltage, flow rate and tip-collector distance). FTIR spectra were sensitive to the low amount of drugs loaded and even showed slight differences in PLA conformation. DSC heating scans clearly demonstrated the ability of electrospinning to induce molecular orientation of PLA and also the nucleation effect of incorporated drugs to induce crystallization. Thus, crystallinity of binary drug-loaded scaffolds was significantly higher than observed for unloaded samples.Release behavior of the three drugs from loaded scaffolds and PLA matrices in PBS:ethanol medium was evaluated. A rapid release was always detected, together with partial drug retention which was higher when the more stereoregular PLA matrix was employed. A strong bactericide effect was found when scaffolds were loaded with 3 w/v-% of TCS, but incorporation of a small percentage of KTP (i.e. 1 w/v-%) had a bacteriostatic effect even in the absence of TCS. The inherent cytotoxicity of TCS could be well neutralized by enhancing cell viability by incorporation of CUM and/or KTP.3

Scaffolds with Tunable Properties Constituted by Electrospun Nanofibers of Polyglycolide and Poly(ε‐caprolactone)

“…Incorporation of drugs into electrospun scaffolds is also an easy process since only minor modifications on the processing parameters are required, being also minimal the repercussion on the final geometry due to the usually low amount of loaded drug that is necessary to get a significant pharmacologic effect. Incorporation of several drugs can provide materials with multifunctional properties . In this work the use of a typical bactericide agent (i.e., polyhexamethylene biguanide (PHMB)) and an anticancerigen drug (i.e., curcumin (CUR)), which in addition has a bacteriostatic effect, was assayed in order to provide a high added value to the new scaffolds.…”

“…Incorporation of several drugs can provide materials with multi functional properties. [22] In this work the use of a typical bactericide agent (i.e., polyhexamethylene biguanide (PHMB)) and an anticancerigen drug (i.e., curcumin (CUR)), which in addition has a bacteriostatic effect, was assayed in order to provide a high added value to the new scaffolds.…”

Design of diffusion‐controlled drug delivery devices for controlled release of Paclitaxel

“…For all these cases, the predicted drug delivery devices resulted in complete release within the specified time durations. Polybutylene succinate and polyvinyl alcohol-based controlled delivery devices are also reported in the open literature that show rapid release in several studies (Li, Wang, & Wu, 1998;Llorens, Ibañez, Del Valle, & Puiggalí, 2015;Shah, Shah, & Pradhan, 1997). It was observed for Case 2 that Paclitaxel was released from polylactic acid in monolithic cylindrical diffusion-controlled drug delivery device of radius 50 nm with initial drug loading of 7.5% (w/w) for 29 days with an optimal AUC of 63.60 × 10 3 ng.day/ml using 122 × 10 7 nanoparticles.…”

Ofloxacin-Loaded PLLA Nanofibrous Mats for Wound Dressing Applications

“…However, the T g remained unaltered, which confirmed that there was no interaction between OFLX and PLLA in the amorphous region. The antibiotic drug disrupts the polymer crystallization, thereby reducing the thermal stability. − DSC curves for the PLLA nanofibrous mats with various formulations are shown in Figure S8.…”