Multilayer Bacteriostatic Coating for Surface Modified Titanium Implants

Vögeling, Hendrik; Duse, Lili; Seitz, Benjamin Sebastian; Plenagl, Nikola; Wojcik, Matthias; Pinnapireddy, Shashank Reddy; Bakowsky, Udo

doi:10.1002/pssa.201700844

Cited by 12 publications

(5 citation statements)

References 36 publications

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“…Previous studies on the impact of polymer coatings on the corrosion resistance of a metal substrate, mainly non-biodegradable coatings, have been performed [23,27,28]. However, there have been a limited number of reports on the impact of biodegradable coatings on the corrosion resistance of metal substrates and their cytotoxicities [18,19,[29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

et al. 2020

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The inhibition of the corrosion of metal implants is still a challenge. This study aimed to increase the corrosion resistance of Ti6Al7Nb alloy implants through surface modification, including grinding, sandblasting, and anodic oxidation followed by the deposition of a polymer coating. The aim of the work was to determine the influence of biodegradable polymer coatings on the physico-chemical properties of a Ti6Al7Nb alloy used for short-term implants. Biodegradable coatings prepared from poly(glycolide-caprolactone) (P(GCap)), poly(glycolide ε-caprolactone-lactide) (P(GCapL)), and poly(lactide-glycolide) (PLGA) were applied in the studies. The dip-coating method with three cycles of dipping was applied. Corrosion resistance was assessed on the basis of potentiodynamic studies. The studies were carried out on samples after 30, 60, and 90 days of exposure to Ringer's solution. Surface topography, wettability, and cytotoxicity studies were also carried out. The degradation process of the base material was evaluated on the basis of the mass density of the metal ions released to the solution. The results indicated the influence of the coating type on corrosion resistance. In addition, a beneficial effect of the polymer coating on the reduction of the density of the released metal ions was found, as compared to the samples without polymer coatings. The obtained results provide basic knowledge for the development of polymer coatings enriched with an active substance. The presence of ciprofloxacin in the coating did not reduce the corrosion resistance of the metal substrate. Moreover, the cytotoxicity test using the extract dilution method demonstrated that the implants' coatings are promising for further in vitro and in vivo studies.The extensive use of biodegradable polymers in medical applications is mainly associated with the possibility of tailoring their physicochemical and mechanical properties. Controlled polymer degradation allows for their use as carriers of medicinal substances, ensuring drug release with regulated dynamics to obtain the expected therapeutic effects [5]. The mentioned group of biopolymers is characterized by an appropriate biocompatibility [4], and the achieved degradation products-mainly lactic, glycolic, and hydroxyhexanoic acids-are found to be neutral to the human organism and are metabolized in accordance the Krebs cycle [6]. The basic limitation of the use of biodegradable polymers relates to the mechanical properties that change over time. This feature may be disadvantageous in some applications, e.g., orthopedic implants. Treatment disorders can be observed as the implant weakens due to degradation processes. This can lead to repeated injuries. The consequence of this is the need to perform a revision surgery combined with the removal of an incompletely degraded and mechanically weakened implant and followed by its replacement with a new one. The revision surgery due to the progressive degradation of the polymer material may be associated with serious difficulties that lead to a much ...

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Section: Introductionmentioning

confidence: 99%

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

et al. 2020

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“…As seen in Figure 1A, the coating process followed a simple UV assisted polymerization process of caffeic acid on the surface of the Titanium foil, the immobilization of metallic silver on the surface was also followed right after the coating of PCA on top of the Ti substrate, Ag ions can be immobilized and reduced to metallic silver particles in situ by using the catechol moiety of the PCA [4]. It has been recently discovered that natural polyphenols can be deposited via electromagnetic radiation (UV-light) to various substrates like glass and stainless steel [26].…”

Section: Resultsmentioning

confidence: 99%

“…It can lead to prolonged hospitalization, financial burden, and even death [1,2]. Infection at the periphery of implants is usually due to two reasons: The attachment and formation of biofilm by microorganisms through colonization and the compromised immune ability at the interface of the implant and tissue [3,4,5]. Microorganisms are able to attach to the implant, especially biocompatible implants due to protein membrane formation [6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

UV Light Assisted Coating Method of Polyphenol Caffeic Acid and Mediated Immobilization of Metallic Silver Particles for Antibacterial Implant Surface Modification

2019

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Titanium implants are extensively used in biomedical applications due to their excellent biocompatibility, corrosion resistance, and superb mechanical stability. In this work, we present the use of polycaffeic acid (PCA) to immobilize metallic silver on the surface of titanium materials to prevent implant bacterial infection. Caffeic acid is a plant-derived phenolic compound, rich in catechol moieties and it can form functional coatings using alkaline buffers and with UV irradiation. This combination can trigger oxidative polymerization and deposition on the surface of metallic substrates. Using PCA can also give advantages in bone implants in decreasing inflammation by decelerating macrophage and osteoclast activity. Here, chemical and physical properties were investigated using FE-SEM, EDS, XPS, AFM, and contact angle. The in vitro biocompatibility and antibacterial studies show that PCA with metallic silver can inhibit bacterial growth, and proliferation of MC-3T3 cells was observed. Therefore, our results suggest that the introduced approach can be considered as a potential method for functional implant coating application in the orthopedic field.

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“…The biofilm adhesion to the titanium plates surface was examined at an accelerating voltage of 10 kV under a vacuum 4 × 10 6 bar using Zeiss (EVO-LS10, Jena, Germany). The images were captured using Smart SEM software, version 5.05 (Zeiss, Jena, Germany) [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Topographical and Ultrastructural Evaluation of Titanium Plates Coated with PLGA, Chitosan, and/or Meropenem: An In Vitro Study

et al. 2022

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The present investigation was undertaken to evaluate the topographical and ultrastructural architecture of titanium plates coated with polylactic co-glycolic acid (PLGA), chitosan (CH), and/or meropenem (MEM) with or without Staphylococcus aureus (SA) or Pseudomonas aeruginosa (PA) bacteria. Single-hole segments of 0.4 mm thick, low-profile titanium plates were spray coated using an airbrush with polymeric carriers (PLGA or CH) loaded with MEM, in addition to the negative control group (uncoated titanium plates). The coated plates and the negative control group were subjected to bacterial biofilms through a cultivation process while being slowly stirred at 20 rpm for 24 h. The samples were fixed and processed for scanning electron microscopic study at 5, 10, and 20 k magnification. The data were statistically analyzed to compare within and between the different materials. Coating titanium plates with PLGA or CH with MEM appeared to enhance bacterial inhibition over uncoated plates, hindering biofilm formation and preventing bacterial proliferation. In the staphylococcus aureus group, the highest bacterial count was observed in the uncoated plates, whereas the lowest count was detected in meropenem-PLGA, followed by PLGA, chitosan, meropenem, and meropenem-chitosan, respectively. On the other hand, the Pseudomonas aeruginosa group with the uncoated plates had the highest bacterial count, whereas the lowest bacterial count was found related to CH, followed by PLGA, MP, MC, and MEM, respectively.

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Multilayer Bacteriostatic Coating for Surface Modified Titanium Implants

Cited by 12 publications

References 36 publications

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

UV Light Assisted Coating Method of Polyphenol Caffeic Acid and Mediated Immobilization of Metallic Silver Particles for Antibacterial Implant Surface Modification

Topographical and Ultrastructural Evaluation of Titanium Plates Coated with PLGA, Chitosan, and/or Meropenem: An In Vitro Study

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