Climate change has unchained several natural extreme phenomena, including a major frequency and intensity of flooding episodes. From these, the ones of greatest importance are those which endanger human settlements as well as socioeconomic activities. This is the case of Tamuín city, settled in the shore of Tampaón River, in Mexico. In this work, we performed a detailed numerical modelling of the hydrodynamics of the zone, considering in situ topographic and bathymetric data as well as hydrodynamic parameters. Severe rainfall scenarios were simulated in order to determine the zones which are prone to flooding, as well as the potential periods of time between the beginning of the rainfall up to the flooding, considering the potential effects of climate change in the precipitation rate. The outcome of this research will help local governments undertake preventive actions to reinforce the identified risky zones, thus providing an adequate protection of rural and urban zones, as well as their inhabitants and their economical activities from current and future floods, considering potential climate change effects.