Multilayered Controlled Released Topical Patch Containing Tetracycline for Wound Dressing

Abstract

Proficient antibiotic drug delivery plays a key role in treating infections. In this article we prepared an electrospun wound dressing which releases Tetracycline in a timed and dose controlled matter for one week. In order to fabricate a wound dressing which can release Tetracycline in a longer duration and at an effective therapeutic level we designed a bilayer electrospun patch made of polyvinyl alcohol (PVA), polycaprolacton (PCL), and coated the whole system with chitosan. The SEM micrograph showed the dependent relationship of the morphology of the nanofibers on the Tetracycline concentration, and the addition of PCL electrospun layer decreased the pore size and water uptake rate. However, it was found that coating PVA/PCL bilayered electrospun sheet with chitosan increased the water uptake rate, which is an important property in biomedical applications. According to the FTIR results, chemical composition of the scaffolds did not change during the fabrication process. Mechanical properties of the samples were assessed, and the results revealed that the chitosan coating improved the tensile strength of the electrospun layers. Furthermore, based on in vitro release tests, it was found that bilayered electrospun sheets coated with chitosan controlled drug release efficiently. In addition, the antibacterial tests performed in vitro showed stronger antibacterial activity on S. aureus cultures for PVA/PCL/Chitosan in comparison to uncoated samples.

Laponite‐Based Nanomaterials for Drug Delivery

“…The drugs’ therapeutic efficacy often depends on the high administration's dosage and frequency, resulting in severe side effects and toxicity. [ 45 ] To tackle this issue, drug carriers that deliver a sufficient amount of the drug to the site of action while maintaining a therapeutic level during the treatment period have been frequently practiced. [ 46 ] Selecting a suitable drug carrier is essential in various pathologies, including infections, cancer, and inflammatory diseases.…”

The single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto poly(lactic acid) electrospun film on wound-healing

“…The water-absorbent properties of the chitosan caused the CCM-containing dressings to possess higher water-uptake compared to other dressings. 43 Montmorillonite incorporation slightly increased the water-uptake capacity of the PLA film, but compared to chitosan, it was negligible. It can be assumed that the water-uptake capacity endowed to the PLA film only originated from the CCMs.…”

Tetracycline-Loaded Electrospun Poly(l-lactide-co-ε-caprolactone) Membranes for One-Step Periodontal Treatment

“…The drug release profile of a polymer matrix (as in S-PLCL and F-PLCL membranes) can be explained by the Fickian diffusion mechanism, which considers the drug penetration as the most important factor in drug release. Other mechanisms can be applied for the rate of drug release such as the release from the surface of the nanofibrous scaffold or the degradation of the polymer matrix. , It is believed that with the increase in concentrations of TC, the dissolved drug in the polymer solution exhibited a greater tendency to migrate to the surface or near the surface of nanofibers during the electrospinning process. Therefore, the exposure and diffusion of the TC from S-PLCL to the buffer solution tended to increase at 168 h, leading to a faster drug release rate.…”