Multilayered Graphene Hydrogel Membranes for Guided Bone Regeneration

Lu, Jiayu; Chen, Cheng; He, Yu; Lyu, Chengqi; Wang, Yufei; Yu, Jia; Qiu, Ling; Zou, Derong; Li, Dan

doi:10.1002/adma.201505375

Cited by 138 publications

(127 citation statements)

References 48 publications

Supporting

Mentioning

127

Contrasting

Order By: Relevance

“…Exploiting this unique property, the rGO hydrogel was tested as artificial barrier membrane for guided bone regeneration in a rat calvarial defect model, in which the membrane successfully maintained osseous space, promoted osteodifferentiation and mineralization, and achieved higher quality and fast bone regeneration (Figure 12D). Inspired by these reports, studies using rGO to improve properties of bioceramics (i.e., HA) based BTE scaffolds have been recently reported. Unlike GO, the effects of rGO on the hydrophilicity of scaffolds were generally not discussed, presumably because the effects were not obvious due to the reduced oxygen content.…”

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

142

106

View full text Add to dashboard Cite

Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

show abstract

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

“…B) Schematic illustration of the cross‐section of the rGO hydrogel membrane with trapped water molecules and the highly densified structure after the removal of water molecules by drying. Adapted with permission . Copyright 2016, Wiley‐VCH.…”

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

142

106

View full text Add to dashboard Cite

show abstract

“…During regeneration, the barrier membrane provides a sealed space that allows bone regeneration, rather than internal growth of connective tissue 30) . The success of GBR, which is reflected by a higher regenerative potential relative to unsupported healing conditions, depends on the properties of the barrier membrane materials, particularly their interactions with osseous and surrounding tissues 31) . The membrane materials should exhibit mechanical properties compatible with bone tissue 32) , which means that the membrane requires sufficiently strong and balanced mechanical strength to maintain the space for bone regeneration during the healing process 33) .…”

mentioning

confidence: 99%

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

et al. 2018

View full text Add to dashboard Cite

The effectiveness of a previously developed unsintered hydroxyapatite (uHA) and poly(L-lactic acid) (PLLA) hydrophilic membrane as a resorbable barrier for guided bone regeneration (GBR) was evaluated. Critical-size 8-mm diameter bone defects were surgically generated in the parietal bones of 24 12-week-old male Wistar rats, which were then divided into three groups in which either a uHA/ PLLA or a collagen membrane or no membrane (control) was placed onto the bone defect. Following sacrifice of the animals 2 or 4 weeks after surgery, bone defects were examined using microcomputed tomography and histological analysis. Bone mineral density, bone mineral content, and relative bone growth area values 2 or 4 weeks after surgery were highest in the uHA/PLLA group. Four weeks after surgery, the relative bone growth area in the uHA/PLLA group was larger than that in the collagen group. The resorbable uHA/PLLA membrane is thus potentially effective for GBR.

show abstract

“…[19,21,31,32] Many scholars have reported that the physical properties of the substrates can regulate the pluripotency of ESCs. [19,21,31,32] Many scholars have reported that the physical properties of the substrates can regulate the pluripotency of ESCs.…”

Section: Discussionmentioning

confidence: 99%

Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency

et al. 2019

View full text Add to dashboard Cite

Culturing embryonic stem cells (ESCs) in vitro usually requires animal‐derived trophoblast cells, which may cause pathogenic and immune reactions; moreover, the poor repeatability between batches hinders the clinical application of ESCs. Therefore, it is essential to synthesize a xenogeneic‐free and chemically well‐defined biomaterial substrate for maintaining ESC pluripotency. Herein, the effects of structurally tunable reduced graphene oxide (RGO) substrates with different physicochemical properties on ESC pluripotency are studied. Colony formation and CCK‐8 assays show that the RGO substrate with an average 30 µm pore size promotes cell survival and proliferation. The unannealed RGO substrate promotes ESC proliferation significantly better than the annealed substrate due to the interfacial hydrophilic groups. The RGO substrate can also maintain ESC for a long time. Additionally, immunofluorescence staining shows that ESCs cultured on an RGO substrate highly express E‐cadherin and β‐catenin, whereas after being modified by Dickkopf‐related protein 1, the RGO substrate is unable to sustain ESC pluripotency. Furthermore, the cell line that interferes with E‐cadherin is also unable to maintain pluripotency. These results confirm that the RGO substrate maintains ESC pluripotency by promoting E‐cadherin‐mediated cell–cell interaction and Wnt signaling.

show abstract

Multilayered Graphene Hydrogel Membranes for Guided Bone Regeneration

Cited by 138 publications

References 48 publications

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency

Contact Info

Product

Resources

About