Multilayered Polyurethane–Hydroxyapatite Composite for Meniscus Replacements

For hydrogel injection applications, it is important to improve the strength and biostability of the hydrogel as well as its injectability to pass easily through the needle. Making gel microspheres is one approach to achieve these improvements. Granulization of a bulk hydrogel is a common procedure used to form microsized particles; however, the nonuniform size and shape cause an uneven force during injection, damaging the surrounding tissue and causing pain to the patients. In this study, injectable hyaluronic acid (HA)-based hybrid hydrogel microspheres were fabricated using a water-in-oil emulsion process. The injectability was significantly enhanced because of the relatively uniform size and spherical shape of the hydrogel formulates. In addition, the biostability and mechanical strength were also increased owing to the increased cross-linking density compared with that of conventionally fabricated gel microparticles. This tendency was further improved after in situ calcium phosphate precipitation. Our findings demonstrate the great potential of HA-based hydrogel microspheres for various clinical demands requiring injectable biomaterials.

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“…For the precipitated gels, a peak corresponding to PO 4 3– appeared at 556 cm –1 , indicating the successful formation of CaP. 36…”

Section: Resultsmentioning

confidence: 93%

“…Therefore, the gel microspheres were formed well without residual oil or degradation of HA. For the precipitated gels, a peak corresponding to PO 4 3– appeared at 556 cm –1 , indicating the successful formation of CaP …”

Section: Resultsmentioning

confidence: 98%

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

et al. 2019

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“…Pore size and size distribution as well as interconnectivity are critical parameters for cellular bioactivity . Porous character of scaffold material governs the cell penetration, nutrient transport along with degradation profile, mechanical behavior, angiogenesis, and differentiation . The influence of pore homogeneity on aforementioned features remains a much lesser studied parameter compared with overall porosity or bulk properties of the scaffold materials.…”

Section: Resultsmentioning

confidence: 99%

Biofabrication of Gelatin Tissue Scaffolds with Uniform Pore Size via Microbubble Assembly

Bayram

Jiang

Gultekinoglu

et al. 2019

Macro Materials & Eng

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The control of pore size and uniform porosity remains as an important challenge in gelatin scaffolds. The precise control in building blocks of tissue scaffolds without any additional porogen is possible with costly equipment and techniques, though some pre‐requirements for polymeric material, such as photo‐polymerizability or sintering ability, may be needed prior to construction. Herein, a method for the fabrication of gelatin scaffolds with homogenous porosity using simple T‐junction microfluidics is described. The size of the microbubbles is precisely controlled with 5% deviation from the average. Porous gelatin scaffolds are obtained by building‐up the monodispersed microbubbles in dilute cross‐linker solutions. The effect of cross‐linker density on pore diameter is also investigated. After cross‐linking, pore size of the resultant five scaffold groups are precisely controlled as 135 ± 11, 193 ± 11, 216 ± 9, 231 ± 5, and 250 ± 12 µm. Porosity ratios above 65% are achieved in every sample group. According to the cell culture experiments, structures support high cell adhesion, viability, and migration through the porous network via interconnectivity. This study offers a practical and economical approach for the preparation of porous gelatin scaffolds with homogenous porosity which can be utilized in diverse tissue engineering applications.

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“…[31] Porous character of scaffold material governs the cell penetration, nutrient transport along with degradation profile, mechanical behaviour, angiogenesis and differentiation. [32][33][34] The influence of pore homogeneity on aforementioned features remains a much lesser studied parameter compared with overall porosity or bulk properties of the scaffold materials. The T-junction microfluidic setup has been used to fabricate microbubbles and particles with a very low polydispersity index.…”

Section: Resultsmentioning

confidence: 99%

Biofabrication of Gelatin Tissue Scaffolds with Uniform Pore Size via Microbubble Assembly

Bayram

Jiang

Gultekinoglu

et al. 2019

Macro Materials & Eng

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Front Cover: Achieving a uniform porosity is crucial in tissue engineering scaffold design. In article number 1900394 by Mohan Edirisinghe and co‐workers, a method for fabricating porogen‐free gelatin scaffolds with a narrow pore size distribution using simple T‐junction microfluidics is described. It offers an economical approach for the preparation of gelatin scaffolds with homogenous porosity which can be utilized in diverse healthcare engineering applications, especially in pore size dependent scenarios.

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Multilayered Polyurethane–Hydroxyapatite Composite for Meniscus Replacements

Cited by 5 publications

References 46 publications

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

Biofabrication of Gelatin Tissue Scaffolds with Uniform Pore Size via Microbubble Assembly

Biofabrication of Gelatin Tissue Scaffolds with Uniform Pore Size via Microbubble Assembly

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