Multilobular tumor of the mandible in a Pekingese dog

Pakhrin, Bidur; Bae, Il-Hong; Jee, Hyang; Kang, Min Sung; Kim, Dae Yong

doi:10.4142/jvs.2006.7.3.297

Cited by 14 publications

(12 citation statements)

References 4 publications

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“…The dog's exophthalmos was originally attributed to breed-related conformation. But the combination of neurologic changes (behavioral) and ocular changes (exophthalmia) with intracranial tumor growth has been described before (Pletcher et al, 1979;Straw et al, 1989;Pakhrin et al, 2006;Psychas et al, 2009;Leonardi et al, 2014). In a review study on 39 dogs, 5% had neurologic symptoms and 15% exophthalmia (Dernell et al, 1998).…”

Section: Discussionmentioning

confidence: 84%

“…The description of the dog of the present study was different from that of previous reviews and case reports (Straw et al, 1989;Groff et al, 1992;Loukopoulos et al, 2003;Banks and Straw, 2004;Jubb et al, 2007;Webb et al, 2009;Leonardi et al, 2014). Although multilobular osteochondrosarcoma appears to be a disease of middle-aged to older, medium-to large-breed dogs, scarce reports of young and small dogs do exist (Jacobson, 1971;Diamond et al, 1980;Fukui and Takamori, 1986;Pakhrin et al, 2006;Bordelon and Rochat, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of dogs with MLO are middle-aged to older dogs (median age at presentation eight years), usually belonging to medium or large breeds (median weight 29 kg) (Straw et al, 1989;Groff et al, 1992;Popvitch et al, 1994;Dernell et al, 1998;Loukopoulos et al, 2003;Jubb et al, 2007). Clinically, these tumors are slow-growing, locally invasive, firm immobile masses on the surface of the skull (Hathcock and Newton, 2000;Pakhrin et al, 2006). Although the bone may be invaded by the tumor, the brain is often compressed rather than infiltrated by the mass, resulting in late-onset neurological signs (Pool, 1990;Dernell et al, 1998).…”

Section: Titanium Mesh Reconstruction Of a Dog's Cranium After Multilmentioning

confidence: 99%

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Reconstructie van de schedel van een hond met een titanium mesh na het verwijderen van een multilobulair osteochondrosarcoom

Casterlé¹,

Goethem²,

Kitshoff³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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An eleven-year-old cavalier King Charles spaniel was presented with a large mass arising from the sagittal crest of the skull. Computed tomography also revealed an intracranial component. A histological diagnosis of multilobular osteochondrosarcoma grade 1 was made from surgical biopsies. Since this tumor type has a moderate aggressive biological behavior characterized by a slow growth, compression of adjacent structures, and only a 30% metastatic rate, surgical resection was performed. A wide partial craniectomy was performed, the skull defect was reconstructed with a designated custom designed titanium mesh and the skin defect closed with a local subdermal plexus flap technique. Histologic evaluation indicated clean surgical margins, which may lead to a long-term survival in this low-grade tumor. Approximately seventeen months after surgical resection, the dog showed no signs of local tumor recurrence or metastasis.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Titanium Mesh Reconstruction Of a Dog's Cranium After Multilmentioning

confidence: 99%

See 1 more Smart Citation

Reconstructie van de schedel van een hond met een titanium mesh na het verwijderen van een multilobulair osteochondrosarcoom

Casterlé¹,

Goethem²,

Kitshoff³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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“…The primary tumours have a characteristic round and smoothly marginated “popcorn ball” appearance on radiographs, and a similar finely granular appearance in the bone window of computed tomography (CT) scans . MLO is most often diagnosed in middle‐aged to older medium or large breed dogs; however, the tumour has also been reported in small and giant breed dogs …”

Section: Introductionmentioning

confidence: 99%

Stereotactic radiation therapy for canine multilobular osteochondrosarcoma: Eight cases

Sweet

Nolan

Yoshikawa

et al. 2019

Vet Comparative Oncology

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Radiotherapy is often considered in the management of canine multilobular osteochondrosarcoma (MLO), but its efficacy against bulky MLO tumours is poorly described. This retrospective case series describes the clinical outcomes of pet dogs with MLO treated with a stereotactic radiation therapy (SRT) prescription of 30 Gy in three consecutive daily 10 Gy fractions. Dogs with an imaging (via computed tomography [CT] scan) and/or pathologic diagnosis of MLO were included. Patient demographics, tumour characteristics, radiation plan dosimetry, toxicity and outcome data were obtained retrospectively from the records. The median progression‐free survival time (MPFST) and median overall survival time (MST) were calculated using a LOGLOG test. Eight dogs were included. None had evidence of metastasis at the time of SRT. Clinical signs associated with the MLO included a mass noted by owner, stertor, vestibular signs, exophthalmos and abnormal mentation. Of the five dogs that had CT scans performed 3 to 9 months after SRT, tumour volume decreased by 26% to 87% in four dogs and increased by 32% in one dog. Late radiation toxicity was documented in three dogs (VRTOG Grade 1 skin and/or ocular, n = 2; Grade 3 central nervous system, n = 1). Confirmed local disease progression (n = 3; two were treated with a second course of SRT) and suspected pulmonary metastasis (n = 2) occurred 90 to 315 days after SRT. The MPFST was 223 days (interquartile range [IQR]: 144.5‐276.5 days). The MST was 329 days (IQR: 241.5‐408 days). This protocol was well‐tolerated, but the duration of response was short‐lived.

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“…Nos cães o TOM ocorre mais frequentemente em animais de meia idade a idosos, com média de idade de 8 anos, de raças médias a grandes e peso corporal de aproximadamente 29 kg [4,11], mas também já foi descrito em raças menores como o pequinês [8].…”

Section: Introductionunclassified

Multilobular Tumor of Bone in a Dog

Gonçalves

Bertolo

Conceição

et al. 2019

Acta Scientiae. Vet.

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Background: Multilobular tumor of bone (MTB) is a primary bone neoplasm, uncommon in dogs. This tumor was called of many names for a long time, as: chondroma rodens, multilobular osteochondrosarcoma, multilobular osteoma, multilobular chondroma, calcificating aponeurotic fibroma, although MTB was preferred chosen, because these other name could be correlated with humans' tumors. This tumor is observed specially in skull bone, although it was reported in zygomatic arc, hard palate, axilla, spine and penis. Mostly happen in big breeds dogs, and middle to old age patients. Clinical signs depending of region and how aggressive the tumor is, usually are related to compression of any structure. The growth of MTB is frequently slow and progressive, locally invasive, occurring relapse after surgical revomal, although the tumor has low to moderate metastatic potential. The aim of this study is to report a case of MTB in a female dog and describe anatomopathological changes. Case: A female dog, mixed breed, 13 year-old, of middleweight was admitted in Pathology Department of College of Agricultural Sciences and Veterinary Medicine (FCAV-Unesp), Campus of Jaboticabal -SP, to be undergone to necropsy. The patient have never shown any epileptic crisis or neurologic signs. In macroscopic examination was found a mass in skull, which invaded the orbit and frontal sinus, but it was not invading brain cavity. The neoplasm had and irregular surface, firm consistent, color was white mixed to red areas, after cut it was granular and rough, and had some point mineralized areas. The lobs of lung had much firm masses, colored gray to white. In cytology it was observed fusiform to polyhedric isolated mesenchymal cells, moderated pleomorphic, basophilic cytoplasm, thin granulated nuclear chromatin, and visible nucleoli that was involved by eosinophilic extracellular matrix. The proposed diagnostic was bone sarcoma. Histopathological assessment showed mesenchymal neoplastic proliferation, and multilobular characteristic, the lobules had different sizes and was well organized, and they were separated by thin conjunctive septs. In the center of lobules, there was an "island" with mineralized or chondroitin bone matrix, in some of these islands there were osteoclast. The cells had moderated pleomorphism and low mitotic activity (three mitotic cells in ten high-power field). At least, it showed big necrosis areas and invasion of near tissue. In lung was observed metastatic areas, which had same histopathologic way of primary neoplasm in skull. That way, the histopathologic exam was similar to Multilobular tumor of bone grade II. Discussion: The MTB is an uncommon neoplasm, which assaults mostly skull bone in large breeds dogs and middle age of eight years old. This case accord to literature about breed size, age and local of tumor. The clinical signs in this dog was related to region what it was growing and near structure compression. Besides that, the patient had lung metastasis, that is the principal metastatic sites according to literature....

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Multilobular tumor of the mandible in a Pekingese dog

Cited by 14 publications

References 4 publications

Reconstructie van de schedel van een hond met een titanium mesh na het verwijderen van een multilobulair osteochondrosarcoom

Reconstructie van de schedel van een hond met een titanium mesh na het verwijderen van een multilobulair osteochondrosarcoom

Stereotactic radiation therapy for canine multilobular osteochondrosarcoma: Eight cases

Multilobular Tumor of Bone in a Dog

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