Multilocular cystic renal cell carcinoma: a clinicopathological, immuno‐ and lectin histochemical study of nine cases

Abstract

Multilocular cystic renal cell carcinoma (MCRCC) is an uncommon variant of renal neoplasm and its histogenesis is unclear. The aim of this study was to use immuno- and lectin histochemistry to delineate histochemical patterns which might indicate the histogenetic origin of MCRCC from a particular part or parts of the nephron. We present our experience with nine cases of MCRCC. Fifteen cases of renal cell carcinoma with cystic degeneration (RCC-CD) were selected for comparison with MCRCC. We carried out clinicopathological and immunohistochemical examinations of the MCRCC cases. Clinically, the prognosis of the patients was quite good, in that all nine patients are alive and without recurrence at the time of this report. The MCRCCs reacted strongly in a higher proportion of cases with the distal nephron markers, such as peanut agglutinin (PNA, 88.9%) and MUC1-core antibody (MUC1, 100%), but none reacted preferentially with proximal nephron markers such as vimentin, Leu M1 and Lotus tetragonolobus (LTA). The RCC-CD tumours reacted with vimentin (40%), Leu M1 (66.7%) and LTA (86.7%). Except for two cases, the RCC-CD tumours did not react with PNA or MUC1 core antibody. These results illustrate the different patterns of expression of MCRCC and RCC-CD and suggest that MCRCC originates from the distal nephron. Therefore, MCRCC should be differentiated from other types of renal cell carcinoma on the basis of the histogenesis of the tumour and the clinicopathological findings.

Concurrent Multilocular Cystic Renal Cell Carcinoma and Leiomyoma in the Same Kidney: Previously Unreported Association

“…Recently, Imura et al carried out a detailed immunohistochemical analysis of multilocular cystic RCC cases [7]. They found that in a high proportion of cases, multilocular cystic RCC reacted strongly with the distal nephron markers, but none reacted preferentially with proximal nephron markers.…”

Cooccurrence of Multilocular Cystic Renal Cell Carcinoma and High-Grade Urothelial Carcinoma in Bladder

“…3) Septas should contain clear cell groups [6,7]. Although most RCCs originate from proximal tubules, a detailed immunohistochemical study performed by Imura et al has shown that MCRCC originates from distal tubules [8]. However, MCRCC's pathology still has not been completely illuminated [9].…”

Identification of a new quaternary association for legume lectins

“…In addition, due to its particular biological property of recognizing L-fucosyl oligosaccharides present in glycoprotein and glycolipid receptors on cells, LTA has been used as a tool in various biochemical studies: (i) in the characterization of antigens and insect cells (Thomas and Surolia, 2000;Napier et al, 1974;Butters and Hughes, 1978) (ii) in examinations of surface saccharide composition in different cells (Mayliepfenninger and Jamieson, 1979;Gurd, 1979) and mainly (iii) in lectin histochemistry of malignant cells for the purpose of investigating anomalous membrane oligosaccharides and differentiating carcinomas (Raedler et al, 1983;Koch et al, 1983;Miettinen et al, 1983;Walker, 1984;Ulrich et al, 1985;Davidsson et al, 1987;Griffiths and Stephenson, 1988;Raju and Lee, 1988;Finne et al, 1989;Imura et al, 2004;Turner et al, 1995).…”