The lipomas in the palm are a rarity and are reported sporadically in the medical literature. Many smaller lesions may even go unnoticed due to minimal clinical symptoms. Clinical suspicion and judicious use of imaging may reveal lesions at an uncommon location. Histological confirmation, however, is the basis of the appropriate diagnosis. We describe two cases of lipoma at uncommon sites with the relevant description of both cases managed by surgical excision and histological confirmation. One case of a mid-palmar lipoma in a 42-year-old female and a lipoma adjacent to the right thumb base near the first web space in a 29-year-old male patient are described. The diagnosis was confirmed on histopathology in both cases. The excision biopsy resulted in complete removal; no recurrence or complication was noted in the follow-up of 6 and 8 months, respectively. Our case report highlights the importance of the early diagnosis and excision before involving adjacent vital structures or growing larger. Clinical suspicion and judicious use of imaging are important for the appropriate diagnosis at an uncommon location.