Multimodal approach to characterization of hydrophilic matrices manufactured by wet and dry granulation or direct compression methods

Kulinowski, Piotr; Woyna-Orlewicz, Krzysztof; Obrał, Jadwiga; Rappen, Gerd-Martin; Haznar-Garbacz, Dorota; Węglarz, Władysław P.; Jachowicz, Renata; Wyszogrodzka, Gabriela; Klaja, J.; Dorożyński, Przemysław

doi:10.1016/j.ijpharm.2015.12.067

Cited by 22 publications

(9 citation statements)

References 17 publications

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“…A similar region of uniform proton density preceding high proton density gradient has been observed in HPMC based quetiapine fumarate matrices. Such a region according to previous works by Ju et al has been denoted as swollen-glassy [29,[41][42][43][44]. With the beginning of the "step" as seen in MR images, a distinctly bright and narrow front was associated with microCT images, suggesting a higher density of the material.…”

Section: Characteristics Of Alg/sna Tabletsmentioning

confidence: 82%

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

et al. 2021

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The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, X-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., “locking” of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.

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Section: Characteristics Of Alg/sna Tabletsmentioning

confidence: 82%

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

et al. 2021

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“…Despite the lack of specificity, the dissolution test is sensitive to physicochemical changes in the drug product and is widely used for evaluation of drug formulations. The combination of dissolution testing with imaging techniques, such as MRI or Fourier transform infrared (FTIR) microscopy, gives the possibility of spatiotemporal characterization of dosage forms during hydration and drug release and consequently can increase specificity (8)(9)(10).…”

Section: D Printing For Fast Prototyping Of Pharmaceutical Dissolutimentioning

confidence: 99%

“…Four regions were assumed: dissolution medium, swollen fully hydrated, partially hydrated, and dry matrix. For other details of image segmentations procedure, see the work by Kulinowski et al (10). Based on the results of image segmentations, volumes of the segmented regions of the matrix were calculated.…”

Section: D Mrimentioning

confidence: 99%

3D Printing for Fast Prototyping of Pharmaceutical Dissolution Testing Equipment for Nonstandard Applications

Dorożyński¹,

Jamróz²,

Węglarz³

et al. 2018

Dissolution Technol.

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Purpose of the research was to assess feasibility of fused deposition techniques (3D printing) for development of analytical equipment dedicated for specific dosage forms and for nonstandard applications. Dissolution profiles as well as 3D magnetic resonance imaging (MRI) of the buccal tablets during hydration in dissolution medium were analyzed. The principal result of the study was the first working example of rapid 3D prototyping of dedicated, MRI-compatible dissolution equipment for mucoadhesive buccal tablets. Rapid prototyping techniques were found to be a fast, inexpensive way to develop a dedicated dissolution testing setup.

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“…The general disadvantage of the capsule, is the fact that, capsule formulation is more expensive as compared to the tablet formulation since the capsule shell has to be bought additionally [3]. Hydrophilic matrix tablets are considered the most popular delivery system for oral controlled-release dosage forms [4,5]. These hydrophilic matrices are mostly accepted because of their biopharmaceutical as well as pharmacokinetics advantages over other conventional dosage forms [6][7][8].This is due to, they offer precise and accurate modulation of drug release due to the hydration of the constituent polymer(s).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Novel Extended Release Trihexyphenidyl Hydrochloride Tablets

Mahdy

Naser²,

Tous

2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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Trihexyphenidyl Hydrochloride (THP) present in the international market as an immediate release tablets), and extended release capsules. The aim of this work was to develop an extended release tablets containing THP for the first time, and to evaluate these tablets according to the official and compendia requirements. DSC thermograms and IR spectroscopy were studied for confirmation of the possible interaction of THP with the investigated excipients. The IR results revealed that there was no evidence of interaction between THP and any of the investigated excipients, The DSC thermograms of physical mixture illustrate distinguished drug peak deformation with Xanthan Gum which in turn reflected that a drug-excipient of Xanthan Gum interaction has occurred. The results of release profile revealed that, none of Eudragit RLPO® trials were conforming the required release profile according to USP 38 (2015) (1). While on using Carbopol 971P® (containing 2 % or 1.5 % Carbopol 971P®) were conforming the required release profile acc). With regard to the mechanism of THP release, it was found that the best fit was achieved by zero order models for F8 and F9. Formulae F8 (containing 2 % Carbopol 971P®) have been chosen for further study of the influence of different conditions of stability and the effect of different packaging materials (30 °C & 40 °C / 75 % RH). Samples were investigated physically and chemically after 15, 60, 120, and 180 days. The results revealed that: the tablets packed in polyvinyl chloride enveloped in aluminum sachet is the most stable one .Also tablets packaged in polyvinyl chloride / polyvinyl dienchloride (PVC / PVDC / Aluminum blisters) have better stability and lower rate of degradation than those tablets packed in PVC / Aluminum blisters.

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Multimodal approach to characterization of hydrophilic matrices manufactured by wet and dry granulation or direct compression methods

Cited by 22 publications

References 17 publications

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

3D Printing for Fast Prototyping of Pharmaceutical Dissolution Testing Equipment for Nonstandard Applications

Preparation and Evaluation of Novel Extended Release Trihexyphenidyl Hydrochloride Tablets

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