Multimodal assessment of normal-appearing corpus callosum is a useful marker of disability in relapsing–remitting multiple sclerosis: an MRI cluster analysis study

Abstract

Within the same homogeneous cohort of patients, we could identify three neuroimaging RRMS clusters characterized by different involvement of normal-appearing CC. Interestingly, these corresponded to three distinct levels of clinical and cognitive disability.

Diffusion tensor imaging and disability progression in multiple sclerosis: A 4‐year follow‐up study

“…Thus, inconsistent results observed in previous studies may relate to technical differences, intrinsic heterogeneity of MS(Barone et al, 2018) and MS cohorts, and different clinical scales used in disability evaluation in MS.Altogether, the results of our longitudinal study suggest that DTI is a sensitive tool in monitoring diffuse abnormalities responsible for disability accumulation, and CC may be a good target for DTI analysis. Thus, inconsistent results observed in previous studies may relate to technical differences, intrinsic heterogeneity of MS(Barone et al, 2018) and MS cohorts, and different clinical scales used in disability evaluation in MS.Altogether, the results of our longitudinal study suggest that DTI is a sensitive tool in monitoring diffuse abnormalities responsible for disability accumulation, and CC may be a good target for DTI analysis.…”

“…). Thus, inconsistent results observed in previous studies may relate to technical differences, intrinsic heterogeneity of MS(Barone et al, 2018) and MS cohorts, and different clinical scales used in disability evaluation in MS.Altogether, the results of our longitudinal study suggest that DTI is a sensitive tool in monitoring diffuse abnormalities responsible for disability accumulation, and CC may be a good target for DTI analysis. We believe that an assessment of the prognostic value of DTI in an MS cohort with variable clinical characteristics such as ours which is typically encountered in everyday practice has practical value, as suggested by others(Harrison et al, 2011).…”

Multicenter Measurements of T1 Relaxation and Diffusion Tensor Imaging: Intra and Intersite Reproducibility

“…Beyond assessing focal lesions, T 1 and DTI measures may be particularly useful as biomarkers for diffuse tissue damage, for which there is still a lack of reliable and specific metrics. NAWM characteristics such as mean T 1 , FA, MD, D ax , and D rad can be studied globally or for specific brain structures such as the corpus callosum (CC), as demonstrated recently by Barone et al who found that, within a homogeneous cohort of patients, three neuroimaging groups could be identified based on DTI‐involvement of normal‐appearing CC, which corresponded to three distinct levels of clinical and cognitive disability . However, before using T 1 or DTI as quantitative measurements in clinical trials, inter‐ and intrasite reproducibility need to be assessed.…”

“…NAWM characteristics such as mean T 1 , FA, MD, D ax , and D rad can be studied globally or for specific brain structures such as the corpus callosum (CC), as demonstrated recently by Barone et al who found that, within a homogeneous cohort of patients, three neuroimaging groups could be identified based on DTI-involvement of normal-appearing CC, which corresponded to three distinct levels of clinical and cognitive disability. 19 However, before using T 1 or DTI as quantitative measurements in clinical trials, inter-and intrasite reproducibility need to be assessed. Previous studies on the reproducibility of T 1 relaxation-derived metrics have found promising results.…”

Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract‐based spatial statistics study

“…Perhaps the impairment of movement due to visual deprivation causes tiny degenerative changes in the CC. Barone et al (Barone et al, 2018) indicated that the integrity of the CC structure was closely associated with cognitive ability. However, there is evidence that blind individuals F I G U R E 2 Comparison of radial diffusivity in patients with monocular blindness and healthy controls.…”