Multimodal Imaging Findings and Multimodal Vision Testing in Neovascular Age-Related Macular Degeneration

Abstract

Confluent absence of autofluorescence was a highly significant predictor of vision testing and serves as an easy parameter to obtain in patients with neovascular age-related macular degeneration.

Spatial Correspondence Between Intraretinal Fluid, Subretinal Fluid, and Pigment Epithelial Detachment in Neovascular Age-Related Macular Degeneration

“…The outer retinal layers in patients presenting with SRF have shown to be damaged less extensively than those in patients with IRC. 11 Recently, SRF has further been associated with higher rates of photoreceptor integrity in patients with diabetic macular edema and central retinal vein occlusion (Philip A-M, et al IOVS 2016;57:ARVO E-Abstract 4164). Furthermore, a reduced risk of the development of RPE atrophy has been discussed as a causative factor.…”

“…Concerning the seemingly beneficial role of SRF, previous reports have suggested reduced rates of concomitant retinal pigment epithelial (RPE) atrophy and fibrosis over time 7,10 as well as reduced damage of outer retinal layers 11 (Philip A-M, et al IOVS 2016;57:ARVO E-Abstract 4164) as responsible for its protective effect on visual function. Clinical observation suggests that retinal locations affected by SRF are less likely to exhibit simultaneous IRC, which may present a morphological condition conferring a protective effect particularly when SRF is located subfoveally.…”

Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests

“…The functional deficit under reduced luminance and/or contrast has been well documented in patients with early and intermediate AMD [14,15] using a number of different functional assessments such as low luminance visual acuity (LLVA) [8,14,[16][17][18], visual acuity (VA) measurements with the Moorfields Vanishing Optotypes Acuity Chart (MAC), which employs high-pass filtered letters [19], contrast sensitivity tests [20][21][22][23]15,24,16,25], and fundus-controlled perimetry [12,[26][27][28]9,9,29]. Combinations of any of these visual function tests might further increase sensitivity to detect changes in visual function in particular in early stages of AMD.…”

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

“…Microperimetry is becoming increasingly popular for the assessment of the differential light sensitivity in macular disease. [1][2][3][4][5][6][7][8] The principal advantage of microperimetry compared with standard automated perimetry (SAP) is the provision of fundus tracking that adjusts the position of each stimulus location to account for fixation instability and/or for eccentric fixation, both of which are common in late stage macular disease. Additionally, the measured sensitiv-ity at any given stimulus location is superimposed, in real time, upon the fundus image thereby providing an indication of the topographical relationship between visual function and fundal abnormality.…”