Multimodal neuroimaging study reveals dissociable processes between structural and functional networks in patients with subacute intracerebral hemorrhage

Zhang, Xiaobing; Yu, Xin; Bao, Qingquan; Yang, Li‐Ming; Sun, Yu; Qi, Peng

doi:10.1007/s11517-019-01953-8

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…Moreover, tinnitus patients showed an increased Eg, but the p ‐value of patients in the EG was larger than that of patients in the IG. Previous studies demonstrated that the increase of Eg in patients indicated an abnormally increased capacity for information transfer across the entire brain, resulting in less efficient global integration (Sporns, 2011 ; Zhang, Yu, et al, 2019 ). In line with the study of Lin et al ( 2020 ), we considered that increased Eg may indicate a more compact global network in tinnitus patients as well; moreover, increased Eg could involve intensified information exchange from distributed regions.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, tinnitus patients showed an increased Eg, but the p-value of patients in the EG was larger than that of patients in the IG. Previous studies demonstrated that the increase of Eg in patients indicated an abnormally increased capacity for information transfer across the entire brain, resulting in less efficient global integration (Sporns, 2011;Zhang, Yu, et al, 2019).…”

Section: Topological Property Alterations Of Structural and Functiona...mentioning

confidence: 99%

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Distinct brain structural‐functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy

Chen

Wang

et al. 2022

Human Brain Mapping

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Topological properties, which serve as the core of the neural network, and their couplings can reflect different therapeutic effects in tinnitus patients. We hypothesized that tinnitus patients with different outcomes after sound therapy (narrowband noise) would have distinct brain network topological alterations. Diffusion tensor imaging and resting-state functional magnetic resonance imaging (fMRI) were prospectively performed in 60 patients with idiopathic tinnitus and 57 healthy controls (HCs). Graph-theoretical network analyses of structural connectivity (SC), functional connectivity (FC), and SC and FC coupling were performed. Associations between clinical performance and graph-theoretical features were also analyzed. Treatment was effective (effective group; EG) in 28 patients and ineffective (ineffective group; IG) in 32 patients. For FC, the patients in the EG showed higher local efficiency than patients in the IG. For SC, patients in both the EG and IG displayed lower normalized characteristic path length, characteristic path length, and global efficiency than the HCs. More importantly, patients in the IG had higher coupling than the HCs, whereas there was no difference in coupling between patients in the EG and HCs.Additionally, there were significant associations between the SC features and clinical performance in patients in the EG. Our findings demonstrate that tinnitus patients exhibited significant brain network topological alterations, especially in the structural brain network.More importantly, patients who demonstrated different curative effects showed distinct SC-FC topological coupling properties. SC-FC coupling could be an indicator that could be used to predict prognoses in patients with idiopathic tinnitus before sound therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Topological Property Alterations Of Structural and Functiona...mentioning

confidence: 99%

Distinct brain structural‐functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy

Chen

Wang

et al. 2022

Human Brain Mapping

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“…In this study, a significantly increased Lp was observed in the structural networks of patients with stroke, indicating that the integration of information and the capacity of neurons to transmit information over long distances were reduced in patients with ischemic stroke. Patients with ischemic stroke showed a decreased Eg, indicating a reduced capacity for information transfer across the entire brain to a less efficient global integration [26, 27]. Overall, these results suggest that the deficits in global integration were common in the brain networks of patients with stroke.…”

Section: Discussionmentioning

confidence: 99%

Alterations of brain network topology and structural connectivity‐functional connectivity coupling in capsular versus pontine stroke

Chen

Geng

Shang

et al. 2021

Euro J of Neurology

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Background and purpose This study was conducted to investigate whether capsular stroke (CS) and pontine stroke (PS) have different topological alterations of structural connectivity (SC) and functional connectivity (FC), as well as correlations of SC‐FC coupling with movement assessment scores. Methods Resting‐state functional magnetic resonance imaging and diffusion tensor imaging were prospectively acquired in 46 patients with CS, 36 with PS, and 29 healthy controls (HCs). Graph theoretical network analyses of SC and FC were performed. Patients with left and right lesions were analyzed separately. Results With regard to FC, the PS and CS groups both showed higher local efficiency than the HCs, and the CS group also had a higher clustering coefficient (Cp) than the HCs in the right lesion analysis. With regard to SC, the PS and CS groups both showed different normalized clustering coefficient (γ), small‐worldness (σ), and characteristic path length (Lp) compared with the HC group. Additionally, the CS group showed higher normalized characteristic path length (λ) and a lower Cp than the HCs and the PS group showed higher λ and lower global efficiency than the HCs in the right‐lesion analysis. However, γ, σ, Cp and Lp were only significantly different in the PS and CS groups compared with the HC group in the right‐lesion analysis. Importantly, the CS group was found to have a weaker SC‐FC coupling than the PS group and the HC group in the right‐lesion analysis. In addition, both patient groups had weaker structural‐functional connectome correlation than the HCs. Conclusions The CS and PS groups both showed FC and SC disruption and the CS group had a weaker SC‐FC coupling than the PS group in the right lesion analysis. This may provide useful information for individualized rehabilitative strategies.

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“…We speculated that the neuroplasticity of the structure might occur later than that of the function. The phenotype of the separation between the structural and functional networks was detected in patients with subacute intracerebral hemorrhage (38). In a rehabilitation practice of peripheral nerve-injured rats, rehabilitation therapy of electroacupuncture for 120 days can induce the neuroplasticity of the structural network, but a treatment duration of only 30 days cannot induce the The number of brain areas corresponds to the code of the automated anatomical labeling (AAL) atlas.…”

Section: Small-world Propertiesmentioning

confidence: 99%

Random Network and Non-rich-club Organization Tendency in Children With Non-syndromic Cleft Lip and Palate After Articulation Rehabilitation: A Diffusion Study

Rao

Cheng

et al. 2022

Front. Neurol.

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ObjectiveThe neuroimaging pattern in brain networks after articulation rehabilitation can be detected using graph theory and multivariate pattern analysis (MVPA). In this study, we hypothesized that the characteristics of the topology pattern of brain structural network in articulation-rehabilitated children with non-syndromic cleft lip and palate (NSCLP) were similar to that in healthy comparisons.MethodsA total of 28 children with NSCLP and 28 controls with typical development were scanned for diffusion tensor imaging on a 3T MRI scanner. Structural networks were constructed, and their topological properties were obtained. Besides, the Chinese language clear degree scale (CLCDS) scores were used for correlation analysis with topological features in patients with NSCLP.ResultsThe NSCLP group showed a similar rich-club connection pattern, but decreased small-world index, normalized rich-club coefficient, and increased connectivity strength of connections compared to controls. The univariate and multivariate patterns of the structural network in articulation-rehabilitated children were primarily in the feeder and local connections, covering sensorimotor, visual, frontoparietal, default mode, salience, and language networks, and orbitofrontal cortex. In addition, the connections that were significantly correlated with the CLCDS scores, as well as the weighted regions for classification, were chiefly distributed in the dorsal and ventral stream associated with the language networks of the non-dominant hemisphere.ConclusionThe average level rich-club connection pattern and the compensatory of the feeder and local connections mainly covering language networks may be related to the CLCDS in articulation-rehabilitated children with NSCLP. However, the patterns of small-world and rich-club structural organization in the articulation-rehabilitated children exhibited a random network and non-rich-club organization tendency. These findings enhanced the understanding of neuroimaging patterns in children with NSCLP after articulation rehabilitation.

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Multimodal neuroimaging study reveals dissociable processes between structural and functional networks in patients with subacute intracerebral hemorrhage

Cited by 4 publications

References 52 publications

Distinct brain structural‐functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy

Distinct brain structural‐functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy

Alterations of brain network topology and structural connectivity‐functional connectivity coupling in capsular versus pontine stroke

Random Network and Non-rich-club Organization Tendency in Children With Non-syndromic Cleft Lip and Palate After Articulation Rehabilitation: A Diffusion Study

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