Multimodal Optical Diagnostics of Glycated Biological Tissues

Smolyanskaya, O. A.; Lazareva, Ekaterina N.; Nalegaev, S. S.; Petrov, Nikolay V.; Zaytsev, Kirill I.; Dyachenko, Polina A.; Tuchina, Daria K.; Toropova, Yana; Kornyushin, O. V.; Бабенко, А. Ю.; Guillet, Jean-Paul; Tuchin, Valery V.

doi:10.1134/s0006297919140086

Cited by 21 publications

(15 citation statements)

References 136 publications

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“… 2 , 3 , 53 Therefore, content and state of water play dominant roles in the formation of the THz dielectric response of hydrated tissues. 21 Similarly to the THz dielectric response of liquid water, aqueous solutions, and biological liquids, 2 , 3 the THz-wave losses in tissues, which are defined by

, possess no resonant features. In the THz range, complex dielectric permittivity of water and hydrated media is usually described by the relaxation models, among which the double-Debye model should be emphasised as the most widely applied in THz biophotonics 48 , 54 – 60

where

is a circular frequency,

and

are times and amplitudes of the “slow” and “fast” relaxations,

is a constant dielectric permittivity at high frequencies [

].…”

Section: Thz-wave--tissue Interactionsmentioning

confidence: 99%

“… 67 – 69 However, an in-depth review of modern research works in the area of the THz dielectric spectroscopy of pure bulk water, aqueous solutions of biomolecules, segregated water, and tissues is far beyond the scope of the present review, but it can be found in Refs. 2 and 21 .…”

Section: Thz-wave--tissue Interactionsmentioning

confidence: 99%

“…1 ), has been observed during the past few decades, 1 – 5 driven by rapid progress in THz technology. 6 , 7 Numerous research papers demonstrate the potential of THz technology in label-free early noninvasive, least-invasive, and intraoperative diagnosis of malignant and benign neoplasms with different nosologies and localizations, 3 , 4 , 8 – 18 sensing of glycated tissues and blood in the context of diabetes diagnosis, 1 , 19 – 21 determining the degree of traumatic injuries, 22 – 25 hydration levels, 26 – 29 and viability 30 of tissues. Along with the diagnostic applications, THz technology holds strong potential in therapeutics, 31 , 32 for example, in nonthermal regulation in expression of genes associated with cancer and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

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Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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where

is a circular frequency,

and

are times and amplitudes of the “slow” and “fast” relaxations,

is a constant dielectric permittivity at high frequencies [

].…”

Section: Thz-wave--tissue Interactionsmentioning

confidence: 99%

Section: Thz-wave--tissue Interactionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cellular effects of terahertz waves

et al. 2021

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“…THz TDS is powerful for material spectroscopy, layer inspection, and transmission imaging of packaged objects. 2 THz-TDS systems are utilized in authentication, [3][4][5] nondestructive inspection, [6][7][8][9][10][11][12][13][14][15][16][17] three-dimensional (3-D) imaging, [18][19][20] quality control, [21][22][23][24][25] airport security, [26][27][28][29][30][31][32] art investigations, [33][34][35][36] detecting damages on wood caused by insects, 37 tomography, [38][39][40][41][42][43] characterization of astrophysical ice, 44 biomedical diagnosis and imaging, [45][46][47][48][49]…”

Section: Introductionmentioning

confidence: 99%

Survey of terahertz photonics and biophotonics

et al. 2020

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We review the advances of terahertz (THz) science and technology in biophotonics, including related challenges and solutions. The main impediment to THz spectroscopy and imaging in this field is the high absorption of the THz beam in water. Hence, transmission imaging and spectroscopy of thick wet tissue using THz radiation has generally been quite difficult. However, the absorption of THz waves by water molecules is so strong that increasing the power of the THz source can lead to structural and functional changes in tissues, so solutions must go beyond a larger power output. In terms of resolution, THz imaging is superior to ultrasound but inferior to visible light microscopy. Owing to its unique material analysis capabilities, promising diagnosis applications have been demonstrated through THz imaging and spectroscopy. Unfortunately, many applications are limited by beam penetration depth and resolution. Hence, researchers from a wide variety of scientific and technical fields have been actively improving these features through the development of electronic devices and materials. In addition, groundbreaking optical architecture and materials to reduce beam absorption in the optics of a system and generate focused beams with smaller diameters have been proposed. On the software side, image processing techniques to computationally enhance the resolution and quality of THz imaging have been proposed. Data science and machine learning to automate the diagnosis of defects and diseases through processing THz images and spectroscopy data have been proposed. We have reviewed the applications of THz radiation in biophotonics and research achievements toward advancing these applications. A conclusion with a roadmap toward increasing the footprint of the THz technology in biophotonics is also proposed.

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“…With rapid progress in terahertz (THz) technology, quite portable and ergonomic THz spectroscopy and imaging systems emerge, thus, pushing research and engineering efforts into applying THz technology in various demanded branches of applied physics and optics, including biomedical optics. [1][2][3][4][5][6] The strong sensitivity of THz waves to the content and state (free or bound) of tissue water 7 leads to novel opportunities in such applications as label-free diagnosis of malignant and benign neoplasms with different nosology and localization, 8,9 diabetes mellitus, [10][11][12] tissue viability 13 and traumatic injuries, 14 and even therapy for cancers and inflammatory diseases. 15,16 Inspired by such rapid progress, the Journal of Biomedical Optics (JBO) has published this special section of papers to capture the most recent advances in THz technology and innovative THz instruments and methods in biology and medicine.…”

mentioning

confidence: 99%