Multimodal theranostic assemblies: double encapsulation of protoporphyrine-IX/Gd<sup>3+</sup>in niosomes

Barlas, F. Baris; Demir, Bilal; Guler, Emine; Senisik, A. Murat; Arican, Halil Armagan; Ünak, Perihan; Tımur, Suna

doi:10.1039/c5ra26737d

Cited by 23 publications

(23 citation statements)

References 66 publications

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“…Due to their unique physical and chemical properties, nanoparticles (NPs) have been exhaustively explored as platforms to deliver imaging and therapeutic agents to target sites. A wide number of nanosized delivery vehicles have been tested for theranostic applications, including quantum dots, superparamagnetic iron oxides NPs, gold NPs, liposomes, or niosomes [4, 5]. Polymer-based NPs are expected to play a significant role in the dawning era of nanotheranostics for personalized medicine [4], as they have shown improved efficacy and selectivity of entrapped or conjugated agents via enhanced permeability and retention (EPR) effect or through a prolonged circulation half-life and sustained drug release [1, 6].…”

Section: Introductionmentioning

confidence: 99%

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

et al. 2017

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The aim of this work was the generation of a multifunctional nanopolymeric system that incorporates IR-780 dye, a near-infrared (NIR) imaging probe that exhibits photothermal and photodynamic properties; and a derivate of α-tocopheryl succinate (α-TOS), a mitochondria-targeted anticancer compound. IR-780 was conjugated to the hydrophilic segment of copolymer PEG-b-polyMTOS, based on poly(ethylene glycol) (PEG) and a methacrylic derivative of α-tocopheryl succinate (MTOS), to generate IR-NP, self-assembled nanoparticles (NPs) in aqueous media which exhibit a hydrophilic shell and a hydrophobic core. During assembly, the hydrophobic core of IR-NP could encapsulate additional IR-780 to generate derived subspecies carrying different amount of probe (IR-NP-eIR). Evaluation of photo-inducible properties of IR-NP and IR-NP-eIR were thoroughly assessed in vitro. Developed nanotheranostic particles showed distinct fluorescence and photothermal behavior after excitation by a laser light emitting at 808 nm. Treatment of MDA-MB-453 cells with IR-NP or IR-NP-eIR resulted in an efficient internalization of the IR-780 dye, while subsequent NIR-laser irradiation led to a severe decrease in cell viability. Photocytoxicity conducted by IR-NP, which could not be attributed to the generation of lethal hyperthermia, responded to an increase in the levels of intracellular reactive oxygen species (ROS). Therefore, the fluorescence imaging and inducible phototoxicity capabilities of NPs derived from IR-780-PEG-b-polyMTOS copolymer confer high value to these nanotheranostics tools in clinical cancer research.

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Section: Introductionmentioning

confidence: 99%

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

et al. 2017

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“…Thereafter, the samples were irradiated at a distance of 10 cm at a dose of 5 Gy radiation dose in 2 min, then incubated at 37 °C for 72 hr at 5% CO 2 . After 72 hr WST test procedure was applied and absorbance values were calculated for each well similarly with our previous work …”

Section: Methodsmentioning

confidence: 99%

⁸⁹Zr Labeled Fe₃O₄@TiO₂ Nanoparticles: In Vitro Afffinities with Breast and Prostate Cancer Cells

Ünak

Tekin

Guldu

et al. 2020

Applied Organom Chemis

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In this study, Fe3O4@TiO2 nanoparticles were synthesized as a new Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) hybrid imaging agent and radiolabeled with 89Zr. In addition, Fe3O4 nanoparticles were synthesized and radiolabeled with 89Zr. Df‐Bz‐NCS was used as bifunctional ligand. The nanoconjugates were characterized with transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. Radiolabeling yields were 100%. Breast and prostate cancer cell affinities and cytotoxicity were determined using in vitro cell culture assays. The results demonstrated that Fe3O4@TiO2 nanoparticles are promising for PET/MR imaging. Finally, unlike Fe3O4 nanoparticles, Fe3O4@TiO2 nanoparticles showed a fluorescence spectrum at an excitation wavelength of 250 nm and an emission wavelength of 314 nm. Therefore, in addition to bearing the magnetic properties of Fe3O4 nanoparticles, Fe3O4@TiO2 nanoparticles display fluorescence emission. This provides them with photodynamic therapy potential. Therefore multimodal treatment was performed with the combination of PDT and RT by using human prostate cancer cell line (PC3). The development of 89Zr‐Df‐Bz‐NCS‐Fe3O4@TiO2 nanoparticles as a new multifunctional PET/MRI agent with photodynamic therapy and hyperthermia therapeutic ability would be very useful.

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“…A variety of drugs with a wide variety of solubilities may be trapped between the aqueous core or membrane bilayers of these structures. Thus, these nanosystems can function as multifunctional platforms that allow the loading of a wide variety of drug molecules . Niosomes can be used for receptor targeted therapy if they combine with a receptor targeted probe (peptide, antibody, or other receptor specific molecules).…”

Section: Characterizationmentioning

confidence: 99%

“…Protoporphyrins are suitable intermediates for photodynamic therapy due to their light‐sensitive properties. At the same time, PP‐IX has more radiosensitizing effect for cancer cells than healthy cells during radiotherapy . In this study, a novel multi‐functional theranostic agent called ‘Niosome‐MnO‐DTPA‐PP(IX)’ structures were fabricated with imaging potentials such as MR and fluorescence imaging as well as selective therapeutic potential of photodynamic and radiotherapy and these nano structures are found to be effective for photodynamic therapy due to the increased stability, lower cytotoxicity and higher affinity towards prostate cancer cells.…”

Section: Characterizationmentioning

confidence: 99%

“…The hydrodynamic sizes were registered as 37.51±12 nm for plain niosomes, 24.49 ±2.54 for MnO NPs, 38.10 ±3.99 for MnO‐DTPA NPs and 78.33±19.59 for Niosome‐MnO‐DTPA‐PP(IX) as shown in Figure and Table . These findings were similar with the previous work in which the size of plain niosomes was reported as 37.51 ± 12 nm with the zeta potential value of −39±8 mV . The evolution of zeta potential further confirms the successful synthesis in each preparing step.…”

Section: Characterizationmentioning

confidence: 99%

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Protoporphyrin‐IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes as Theranostic

et al. 2020

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Purpose of this study is to develop a multifunctional theranostic agent for both imaging (MR and fluorescence) and combined therapy (photodynamic and radiotherapy). Initially, manganese oxide nanoparticles (MnO NPs) were synthesized and conjugated with diethylenetriaminepentaacetic acid (DTPA) which will be then called as MnO‐DTPA NPs, and at the final step, synthesized MnO NPs were encapsulated with niosomes in the presence of protoporphyrin‐IX (PP(IX)). In vitro cell culture and bioaffinity studies were performed on PC‐3 and BJ cells. The structures (Niosome‐MnO‐DTPA‐PP(IX)) have fluorescence properties and photodynamic therapy potential due to the presence of PP(IX) as well as MR imaging and photodynamic and radiotherapy efficiency. According to data, it was claimed that toxicity of MnO NPs were significantly decreased after encapsulation of niosomes especially for BJ cell line. Therapy potential of the ‘Niosome‐MnO‐DTPA‐PP(IX)’ was examined and promising findings were obtained for the potential use of combined therapy agent for prostate cancer cells.

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Multimodal theranostic assemblies: double encapsulation of protoporphyrine-IX/Gd³⁺in niosomes

Abstract: Theranostically engineered protoporphyrin IX/Gd3+encapsulated niosomes were prepared and used as multimodal theranostic agent.

Cited by 23 publications

References 66 publications

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

⁸⁹Zr Labeled Fe₃O₄@TiO₂ Nanoparticles: In Vitro Afffinities with Breast and Prostate Cancer Cells

Protoporphyrin‐IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes as Theranostic

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Multimodal theranostic assemblies: double encapsulation of protoporphyrine-IX/Gd3+in niosomes

Abstract: Theranostically engineered protoporphyrin IX/Gd3+encapsulated niosomes were prepared and used as multimodal theranostic agent.

Cited by 23 publications

References 66 publications

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

89Zr Labeled Fe3O4@TiO2 Nanoparticles: In Vitro Afffinities with Breast and Prostate Cancer Cells

Protoporphyrin‐IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes as Theranostic

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Multimodal theranostic assemblies: double encapsulation of protoporphyrine-IX/Gd³⁺in niosomes

⁸⁹Zr Labeled Fe₃O₄@TiO₂ Nanoparticles: In Vitro Afffinities with Breast and Prostate Cancer Cells