Multimodal ultrasound tomography for breast imaging: a prospective study of clinical feasibility

Forte, Serafino; Dellas, Sophie; Stieltjes, Bram; Bongartz, B.

doi:10.1186/s41747-017-0029-y

Cited by 12 publications

(11 citation statements)

References 17 publications

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“…[32] Using multimodal ultrasound tomography, which combines SoS with other biomarkers, such as acoustic attenuation, Forte et al did not observe statistically significant changes over the menstrual cycle. [33] Our results indicate that variations of breast density within the menstrual cycle, if at all present, are small (SoS variation 95% CI [−1.1,7.5] m/s equivalent to breast density variations between [−1.1,7.5]%). We found that there is no statistically significant difference in SoS and ΔSoS between the follicular and luteal phase among volunteers with very dense breasts.…”

Section: Discussionmentioning

confidence: 74%

Breast Density Assessment in Young Women with Ultrasound based on Speed of Sound: Influence of the Menstrual Cycle

et al. 2019

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To investigate changes in breast density (BD) during the menstrual cycle in young women in comparison to inter-breast and -segment changes as well as reproducibility of a novel Speed-of-Sound (SoS) Ultrasound (US) method. SoS-US uses a conventional US system with a reflector and a software add-on to quantify SoS in the retro-mammillary, inner and outer segments of both breasts. Twenty healthy women (18–40 years) with regular menstrual cycles were scanned twice with two weeks in-between. Three of these were additionally measured twice per week for 25 days. Average SoS (m/s) and ΔSoS (segment-variation SoS; m/s) were measured. Variations between follicular and luteal phases and changes over the four-week period were assessed. Inter-examiner and inter-reader agreements were also evaluated. Variances between cycle phases, examiners and readers were compared. No significant SoS difference was observed between follicular and luteal phases for the twenty women ( P = .126), and between all different days for the three more frequently measured women ( P = .892). Inter-reader (ICC = 0.999) and inter-examiner (ICC = 0.990) agreements were high. The SoS variance due to menstrual variations was not significantly larger than the inter-examiner uncertainty ( P = .461). Inter-reader variations were significantly smaller than menstrual and examiner variations ( P < .001). SoS-US showed high inter-examiner and inter-reader reproducibility. The alterations during the menstrual cycles were not significantly larger than the confidence interval of measurements.

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Section: Discussionmentioning

confidence: 74%

Breast Density Assessment in Young Women with Ultrasound based on Speed of Sound: Influence of the Menstrual Cycle

et al. 2019

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“…Transmission-mode ultrasound-computed tomography (TUCT) can instead map the distribution of speed of sound and acoustic attenuation, which are representative of a different set of physiological tissue properties, such as stiffness, density, and temperature 20,21 . In this regard, TUCT has been used to map the distribution of speed of sound (SoS) and acoustic attenuation (AA) in the female breast 22,23 , where recent clinical trials suggest a superior performance with respect to standard screening approaches in terms of safety, examination time, and patient comfort 24–26 .…”

Section: Introductionmentioning

confidence: 99%

Transmission–reflection optoacoustic ultrasound (TROPUS) computed tomography of small animals

et al. 2019

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Rapid progress in the development of multispectral optoacoustic tomography techniques has enabled unprecedented insights into biological dynamics and molecular processes in vivo and noninvasively at penetration and spatiotemporal scales not covered by modern optical microscopy methods. Ultrasound imaging provides highly complementary information on elastic and functional tissue properties and further aids in enhancing optoacoustic image quality. We devised the first hybrid transmission–reflection optoacoustic ultrasound (TROPUS) small animal imaging platform that combines optoacoustic tomography with both reflection- and transmission-mode ultrasound computed tomography. The system features full-view cross-sectional tomographic imaging geometry for concomitant noninvasive mapping of the absorbed optical energy, acoustic reflectivity, speed of sound, and acoustic attenuation in whole live mice with submillimeter resolution and unrivaled image quality. Graphics-processing unit (GPU)-based algorithms employing spatial compounding and bent-ray-tracing iterative reconstruction were further developed to attain real-time rendering of ultrasound tomography images in the full-ring acquisition geometry. In vivo mouse imaging experiments revealed fine details on the organ parenchyma, vascularization, tissue reflectivity, density, and stiffness. We further used the speed of sound maps retrieved by the transmission ultrasound tomography to improve optoacoustic reconstructions via two-compartment modeling. The newly developed synergistic multimodal combination offers unmatched capabilities for imaging multiple tissue properties and biomarkers with high resolution, penetration, and contrast.

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“…with circular or rotating transducer setups, for a well-determined tomographic reconstruction. This leads to a complicated setup and acquisition workflow, hindering the clinical translation of USCT [16]- [19].…”

Section: Introductionmentioning

confidence: 99%

Speed-of-Sound Imaging Based on Reflector Delineation

Sanabria

Rominger

Göksel

2019

IEEE Trans. Biomed. Eng.

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Speed-of-sound (SoS) has large potential for tissue and pathology differentiation. We aim to develop a novel Ultrasound Computed Tomography (USCT) technique that can reconstruct local SoS in tissue on conventional ultrasound machines with hand-held linear arrays. Methods: A passive reflector is placed opposite the tissue sample as an echogenic reference to measure the time-of-flight (ToF) of ultrasound wavefronts. A Dynamic Programming algorithm provides a robust ToF measurements based on global optimization of all transmit-receive echo data. An Anisotropically-Weighted Total Variation (AWTV) algorithm allows sharp delineation of focal lesions based on limited-angle USCT data. Results: Inclusions, which are not visible in conventional ultrasound, could be delineated in SoS images. AWTV allows to reconstruct focal lesions with a contrast-ratio of 93.7% of their nominal value, compared to that of 31.5% with conventional least-squares based algebraic tomographic reconstruction. In fullwave simulations of realistic heterogeneous breast models, a high CR of 84.3% is observed, with the reconstruction filtering out background heterogeneity. In experiments, our proposed method quantifies SoS in a homogeneous background with an accuracy of 0.93 m s −1 , allowing to differentiate several tissue types. Conclusion: We validate our method using numerical simulations with ray-tracing and full-wave models, and phantom and ex-vivo data. Preliminary in-vivo results show the potential of this new technique to detect and differentiate malignant and benign lesions in the breast. Significance: Breast cancer is the most common cancer in women. Ultrasound B-mode only provides qualitative information about breast lesions, whereas USCT can provide quantitative tissue imaging biomarkers, such as SoS. The proposed method can potentially be implemented as a complementary modality to ultrasound for tissue and disease differentiation.

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Multimodal ultrasound tomography for breast imaging: a prospective study of clinical feasibility

Cited by 12 publications

References 17 publications

Breast Density Assessment in Young Women with Ultrasound based on Speed of Sound: Influence of the Menstrual Cycle

Breast Density Assessment in Young Women with Ultrasound based on Speed of Sound: Influence of the Menstrual Cycle

Transmission–reflection optoacoustic ultrasound (TROPUS) computed tomography of small animals

Speed-of-Sound Imaging Based on Reflector Delineation

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