Multimodale interdisziplinäre Therapie als Voraussetzung für Verbesserungen von Funktion und Langzeitüberleben bei Patienten mit einem hochmalignen Osteosarkom der Extremitäten

Böhm, Paul; Raecke, Olaf

doi:10.1007/s00104-002-0483-8

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…Wir haben die Erfahrung gemacht, dass eine enge interdisziplinäre Zusammenarbeit von Onkologen, Radiologen, Gefäßchirurgen, Unfallchirurgen, Orthopäden und Plastischen Chirurgen entscheidend ist, um eine optimale Patientenversorgung zu gewährleisten. So kann zum Beispiel durch die Kombination von optimierter Diagnostik, effektiver (neo)adjuvanter Chemotherapie, suffizienter Lokaltherapie mit weiter Re-sektionsgrenze und -falls erforderlich -aggressiver Metastasentherapie bei Patienten mit einem Osteosarkom der Extremitäten sowohl ein kumulatives Überleben von zirka 80 % erreicht als auch in einem hohen Prozentsatz die Extremität mit einem guten funktionellen Langzeitergebnis erhalten werden [2,13,14].…”

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Senkung der Amputationsrate bei Knochen- und Weichgewebssarkomen durch interdisziplinäres Vorgehen

Prantl

Roll²,

Feser³

et al. 2006

Handchir Mikrochir plast Chir

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On the basis of three patients with bone and soft tissue sarcoma,we would like to illustrate the necessity of a well working inter-disciplinary cooperation of radiologists, internal oncologists, radiation therapists, orthopaedic surgeons and plastic surgeons. Functional extremity preservation in sarcoma patients can be achieved by a good interdisciplinary management without im-pairing the total prognosis of the patients. Patients with sarcoma should be treated in centres in which all specialised divisions are experienced and well trained in the treatment of tumour patients. Only then can a promising approach be achieved.

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Senkung der Amputationsrate bei Knochen- und Weichgewebssarkomen durch interdisziplinäres Vorgehen

Prantl

Roll²,

Feser³

et al. 2006

Handchir Mikrochir plast Chir

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Resection of recurrent pulmonary metastases in patients with osteosarcoma

Briccoli

Rocca

Salone

et al. 2005

Cancer

135

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BACKGROUNDSurgical resection of lung metastases is widely accepted in osteosarcoma patients. Few data exist on treatment of recurrent pulmonary metastases. The authors of the current study retrospectively analyzed patients with osteosarcoma who received surgery for recurrent lung metastases.METHODSFrom 1980 to 2001, 127 metastasectomies were performed on 94 patients. Criteria of eligibility were no metastases beyond the lung, no local recurrence, possibility of achieving complete resection of metastases without causing respiratory insufficiency, acceptable operative risk. Data were statistically elaborated with survival analysis according to Kaplan–Meier method of univariate analysis, life tables and Gehan statistic model, and multivariate analysis using Cox regression test. Results were considered in terms of time from first (DFI1) and second (DFI2) metastasectomy.RESULTSOf 94 patients operated upon twice, 59 (62.7%) died. Thirty‐five (37.3%) are alive; 31 (32.9%) of these are continuously disease‐free. The 3‐ and 5‐year event‐free actuarial survival curve from first metastasectomy was 45%, and 38%, respectively, whereas from the second metastasectomy, it was 33% and 32%, respectively. According to a Cox regression model, DFI1 has a risk of death of 0.974 times and DFI2 of 0.972 times for every additional month of survival. In multivariate analysis, Cox regression test showed the best predictive model of local recurrence and number of metastases (P = 0.0014).CONCLUSIONSThe authors concluded that patients persistently free of the primary osteosarcoma who developed recurrent resectable metastatic disease of the lung should be considered for reoperation a second, third, or fourth time, as these patients had similar DFI curves after five‐years. Cancer 2005. © 2005 American Cancer Society.

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Influence of local recurrence on survival in patients with extremity osteosarcoma treated with neoadjuvant chemotherapy

Bacci

Longhi

Cesari

et al. 2006

Cancer

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Objective This study was undertaken to investigate L‐type calcium channel blockers of the dihydropyridine class for association with Parkinson disease (PD), because some of these drugs traverse the blood–brain barrier, are potentially neuroprotective, and have previously been evaluated for impact on PD risk. Methods We identified 1,931 patients with a first‐time diagnosis for PD between 2001 and 2006 as reported in the Danish national hospital/outpatient database and density matched them by birth year and sex to 9,651 controls from the population register. The index date for cases and their corresponding controls was advanced to the date of first recorded prescription for anti‐Parkinson drugs, if prior to first PD diagnosis in the hospital records. Prescriptions were determined from the national pharmacy database. In our primary analyses, we excluded all calcium channel blocker prescriptions 2 years before index date/PD diagnosis. Results Employing logistic regression analysis adjusting for age, sex, diagnosis of chronic pulmonary obstructive disorder, and Charlson comorbidity score, we found that subjects prescribed dihydropyridines (excludes amlodipine) between 1995 and 2 years prior to the index date were less likely to develop PD (odds ratio, 0.73; 95% confidence interval, 0.54–0.97); this 27% risk reduction did not differ with length or intensity of use. Risk estimates were close to null for the peripherally acting drug amlodipine and for other antihypertensive medications. Interpretation Our data suggest a potential neuroprotective role for centrally acting L‐type calcium channel blockers of the dihydropyridine class in PD that should be further investigated in studies that can distinguish between types of L‐type channel blockers. ANN NEUROL 2010;67:600–606

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Multimodale interdisziplinäre Therapie als Voraussetzung für Verbesserungen von Funktion und Langzeitüberleben bei Patienten mit einem hochmalignen Osteosarkom der Extremitäten

Cited by 5 publications

References 47 publications

Senkung der Amputationsrate bei Knochen- und Weichgewebssarkomen durch interdisziplinäres Vorgehen

Senkung der Amputationsrate bei Knochen- und Weichgewebssarkomen durch interdisziplinäres Vorgehen

Resection of recurrent pulmonary metastases in patients with osteosarcoma

Influence of local recurrence on survival in patients with extremity osteosarcoma treated with neoadjuvant chemotherapy

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