2023
DOI: 10.2478/raon-2023-0008
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Multimodality CT imaging contributes to improving the diagnostic accuracy of solitary pulmonary nodules: a multi-institutional and prospective study

Abstract: Background Solitary pulmonary nodules (SPNs) are one of the most common chest computed tomography (CT) abnormalities clinically. We aimed to investigate the value of non-contrast enhanced CT (NECT), contrast enhanced CT (CECT), CT perfusion imaging (CTPI), and dual- energy CT (DECT) used for differentiating benign and malignant SPNs with a multi-institutional and prospective study. Patients and methods Patients with 285 SPNs … Show more

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Cited by 3 publications
(2 citation statements)
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“…A multi-institutional and prospective study investigated the value of morphological criteria in non-contrast and contrast-enhanced CT, using data from perfusion CT imaging, and DECT in differentiating benign and malignant solitary pulmonary nodules. A total of 285 solitary pulmonary nodules were scanned with the different techniques and the value of normalized IC in the venous phase, with a threshold of 0.35, showed an AUC of 0.79, a sensitivity of 75.45%, and a specificity of 80.51% [50]. Ha et al investigated the use of DECT for the differential between lung metastases and benign pulmonary nodules diagnosis in patients affected by thyroid carcinoma; the authors retrospectively studied the spectral data of 153 nodules in 63 patients (55 lung metastases and 97 benign nodules).…”
Section: Lungmentioning
confidence: 99%
“…A multi-institutional and prospective study investigated the value of morphological criteria in non-contrast and contrast-enhanced CT, using data from perfusion CT imaging, and DECT in differentiating benign and malignant solitary pulmonary nodules. A total of 285 solitary pulmonary nodules were scanned with the different techniques and the value of normalized IC in the venous phase, with a threshold of 0.35, showed an AUC of 0.79, a sensitivity of 75.45%, and a specificity of 80.51% [50]. Ha et al investigated the use of DECT for the differential between lung metastases and benign pulmonary nodules diagnosis in patients affected by thyroid carcinoma; the authors retrospectively studied the spectral data of 153 nodules in 63 patients (55 lung metastases and 97 benign nodules).…”
Section: Lungmentioning
confidence: 99%
“…Therefore, tumors also can theoretically take blood from the pulmonary artery, which has been con rmed by postmortem stereoscopic microangiography and in vivo experiments [17][18]. In most previous studies on lung CT perfusion, the aorta has been considered to be the sole input artery in a single-input perfusion model [19,20]. This model re ects the dominant blood supply to lung tumors but often ignores the blood perfusion of the lesser blood supply parts.…”
Section: Introductionmentioning
confidence: 99%