Multimodality high resolution wrist imaging for monitoring response to therapy in rheumatoid arthritis: Instrumentation and techniques

Chaudhari, Abhijit J.; Burkett, George W.; Bowen, Samuel P.; Harse, R.; Packard, N.; Stern, Robin L; Naguwa, Stanley M.; Hunter, John C.; Boone, John M.; Buonocore, Michael H.; Badawi, Ramsey D.

doi:10.1109/nssmic.2008.4774327

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…A device such as the one described here can also be used to image other extremities and we are currently exploring the possibility of using it to image response to therapy in the wrist for patients with rheumatoid arthritis (Chaudhari et al , 2008a). …”

Section: Discussionmentioning

confidence: 99%

PET characteristics of a dedicated breast PET/CT scanner prototype

Bowen

Yang

et al. 2009

Phys. Med. Biol.

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A dedicated breast PET/CT system has been constructed at our institution, with the goal of having increased spatial resolution and sensitivity compared to whole-body systems. The purpose of this work is to describe the design and the performance characteristics of the PET component of this device. Average spatial resolution of a line source in warm background using maximum a posteriori (MAP) reconstruction was 2.5 mm, while average spatial resolution of a phantom containing point sources using filtered back projection (FBP) was 3.27 mm. A sensitivity profile was computed with a point source translated across the axial field of view (FOV) and the peak sensitivity of 1.64% was measured at the center of FOV. Average energy resolution determined on a per-crystal basis was 25%. Characteristic dead time for the front-end electronics and data acquisition (DAQ) was determined to be 145 ns and 3.6 µs, respectively. With no activity outside the FOV, a peak noise-equivalent count rate of 18.6 kcps was achieved at 318 µCi (11.766 MBq) in a cylindrical phantom of diameter 75 mm. After the effects of exposing PET detectors to x-ray flux were evaluated and ameliorated, the combined PET/CT scan was performed. The percentage standard deviations of uniformity along axial and transaixal directions were 3.7% and 2.8%, respectively. The impact of the increased reconstructed spatial resolution compared to typical whole-body PET scanners is currently being assessed in a clinical trial.

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Section: Discussionmentioning

confidence: 99%

PET characteristics of a dedicated breast PET/CT scanner prototype

Bowen

Yang

et al. 2009

Phys. Med. Biol.

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“…Dilation and erosion operations were then performed to delineate the bone. The details of this procedure are reported in [59]. The segmentation procedure was repeated for the follow-up scan.…”

Section: Methodsmentioning

confidence: 99%

Registration-Based Morphometry for Shape Analysis of the Bones of the Human Wrist

Joshi

Leahy

Badawi

et al. 2016

IEEE Trans. Med. Imaging

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We present a method that quantifies point-wise changes in surface morphology of the bones of the human wrist. The proposed method, referred to as Registration-based Bone Morphometry (RBM), consists of two steps: an atlas selection step and an atlas warping step. The atlas for individual wrist bones was selected based on the shortest l2 distance to the ensemble of wrist bones from a database of a healthy population of subjects. The selected atlas was then warped to the corresponding bones of individuals in the population using a non-linear registration method based on regularized l2 distance minimization. The displacement field thus calculated showed local differences in bone shape that then were used for the analysis of group differences. Our results indicate that RBM has potential to provide a standardized approach to shape analysis of bones of the human wrist. We demonstrate the performance of RBM for examining group differences in wrist bone shapes based on sex and between those of the right and left wrists in healthy individuals. We also present data to show the application of RBM for tracking bone erosion status in rheumatoid arthritis.

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“…A patient-specific immobilizer (fabrication time ,5 min) was created for the most symptomatic hand to limit intrascan motion. 21 Patients received an i.v. injection of 18 F-FDG and rested quietly for 60 min in the University of California Davis Medical Center's radiotracer uptake rooms.…”

Section: Patient Selection and Characteristicsmentioning

confidence: 99%

“…Two sets of scans were conducted for most symptomatic wrists and hands: 1 a three-dimensional T 1 weighted (T1w) spoiled gradient-recalled echo sequence in both the coronal and axial direction (repetition time/echo time 5 8.5/4.2 ms) with and without fat suppression and a two-dimensional short tau inversion recovery (STIR) sequence in the coronal direction (repetition time/echo time 5 4000/20 ms, inversion time 5 150 ms). In one subject, a power injector was used to inject the gadopentetate dimeglumine contrast agent at the rate of 1 ml s 21 . A single static T1w scan (same parameters as those for the T1w scan above, coronal direction, fat suppression on) was recorded at 4 min after the completion of contrast injection.…”

Section: Patient Selection and Characteristicsmentioning

confidence: 99%

High-resolution¹⁸F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

Chaudhari¹,

Ferrero²,

Godinez³

et al. 2016

BJR

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Objective: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) commonly affect the small joints of the wrist and hand. We evaluated the performance of a new, highresolution extremity positron emission tomography (PET)/CT scanner for characterizing and quantifying pathologies associated with the two arthritides in the wrist and hand joints. Methods: Patients with RA or PsA underwent fluorine-18 fludeoxyglucose ( 18 F-FDG) PET/CT wrist and hand imaging, respectively, on the high-resolution scanner. Calibrated CT images and co-registered PET images were reconstructed. PET/CT was derived for the radiocarpal and pisiform-triquetral compartments, joints with erosive changes, sites of synovitis or tenosynovitis and the nail bed and were correlated with clinical and MRI findings.

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Multimodality high resolution wrist imaging for monitoring response to therapy in rheumatoid arthritis: Instrumentation and techniques

Cited by 4 publications

References 26 publications

PET characteristics of a dedicated breast PET/CT scanner prototype

PET characteristics of a dedicated breast PET/CT scanner prototype

Registration-Based Morphometry for Shape Analysis of the Bones of the Human Wrist

High-resolution¹⁸F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

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Multimodality high resolution wrist imaging for monitoring response to therapy in rheumatoid arthritis: Instrumentation and techniques

Cited by 4 publications

References 26 publications

PET characteristics of a dedicated breast PET/CT scanner prototype

PET characteristics of a dedicated breast PET/CT scanner prototype

Registration-Based Morphometry for Shape Analysis of the Bones of the Human Wrist

High-resolution18F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

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Product

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High-resolution¹⁸F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study