Multimodality imaging‐guided left ventricular lead placement in cardiac resynchronization therapy: a randomized controlled trial

Abstract

Multimodality imaging-guided LV lead placement towards the CS branch closest to latest mechanically activated non-scarred myocardial LV segment reduces the proportion of clinical non-responders to CRT. Larger long-term multicentre studies are needed.

Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques

“…31 Additional CMR-FT strain analysis of the septum could potentially expand diagnostic yield of this comprehensive imaging technique. At present, various strain parameters and multiple imaging techniques have been proposed to serve as clinical markers of CRT response.…”

Effects of cardiac resynchronization therapy after inferior myocardial infarction on secondary mitral regurgitation and mitral valve geometry

“…This may have underestimated the true burden of myocardial scar in the cohort, which is more accurately assessed utilizing cardiac magnetic resonance imaging or radionuclide myocardial perfusion imaging, and was not available in any patients from the current cohort . Fourth, image‐guided selection of the LV pacing site, which allows for the identification of nonscarred myocardial segments and may improve CRT response, was not routinely performed . In two patients with inferolateral scar, the LV lead was in the lateral and posterolateral CS branches, respectively, and the clinical impact of these variables is unknown.…”

“…38 Fourth, image-guided selection of the LV pacing site, which allows for the identification of nonscarred myocardial segments and may improve CRT response, was not routinely performed. 39 In two patients with inferolateral scar, the LV lead was in the lateral and posterolateral CS branches, respectively, and the clinical impact of these variables is unknown. Fifth, nearly half of the patients had an interventricular conduction delay or were right ventricular paced at baseline.…”

The effects of cardiac resynchronization therapy on left ventricular and mitral valve geometry and secondary mitral regurgitation in patients with left bundle branch block

“…Thirdly, selection of the coronary sinus branch implanted by cardiac magnetic resonance imaging, myocardial perfusion imaging, or speckle‐tracking echocardiography, to identify the nonscarred myocardial segments with the most delayed mechanical activation was not performed. This strategy may improve response to CRT and clinical outcomes, and the effect this may have had in the current cohort is unknown . Fourthly, the details regarding the type and specific guideline‐directed medical therapy utilized were available only at baseline, with no information regarding follow‐up alterations and compliance with treatment regimens available.…”