Multimodality Intracoronary Imaging With Near-Infrared Spectroscopy and Intravascular Ultrasound in Asymptomatic Individuals With High Calcium Scores

Madder, Ryan D.; VanOosterhout, Stacie; Klungle, David; Mulder, Abbey; Elmore, Matthew; Decker, Jeffrey; Langholz, David; Boyden, Thomas F.; Parker, Jessica; Muller, James E.

doi:10.1161/circimaging.117.006282

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…Macrophage accumulation and foam cell formation play a major role in atherosclerotic plaque initiation and progression. Chemical analysis of human atherosclerotic plaques reveals high content and composition of lipids rich in cholesterol and the lipid-rich plaques are strongly associated with majority of acute systemic cardiovascular events among patients with clinically established atherosclerotic disease ( Guyton and Klemp, 1996 , Sun et al, 2017 , Madder et al, 2017 ). RCT is a protective mechanism through multi-steps to move cholesterol from peripheral tissues such as the vessel macrophages back to liver and then excretion from the body ( von Eckardstein et al, 2001 ).…”

Section: Discussionmentioning

confidence: 99%

Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression

Guo

Yuan

et al. 2018

EBioMedicine

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Targeting at enhancing reverse cholesterol transport (RCT) is apromising strategy for treating atherosclerosis via infusion of reconstitute high density lipoprotein (HDL) as cholesterol acceptors or increase of cholesterol efflux by activation of macrophage liver X receptors (LXRs). However, systemic activation of LXRs triggers excessive lipogenesis in the liver and infusion of HDL downregulates cholesterol efflux from macrophages. Here we describe an enlightened strategy using phospholipid reconstituted apoA-I peptide (22A)-derived synthetic HDL (sHDL) to deliver LXR agonists to the atheroma and examine their effect on atherosclerosis regression in vivo. A synthetic LXR agonist, T0901317 (T1317) was encapsulated in sHDL nanoparticles (sHDL-T1317). Similar to the T1317 compound, the sHDL-T1317 nanoparticles upregulated the expression of ATP-binding cassette transporters and increased cholesterol efflux in macrophages in vitro and in vivo. The sHDL nanoparticles accumulated in the atherosclerotic plaques of ApoE-deficient mice. Moreover, a 6-week low-dose LXR agonist-sHDL treatment induced atherosclerosis regression while avoiding lipid accumulation in the liver. These findings identify LXR agonist loaded sHDL nanoparticles as a promising therapeutic approach to treat atherosclerosis by targeting RCT in a multifaceted manner: sHDL itself serving as both a drug carrier and cholesterol acceptor and the LXR agonist mediating upregulation of ABC transporters in the aorta.

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Section: Discussionmentioning

confidence: 99%

Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression

Guo

Yuan

et al. 2018

EBioMedicine

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“…However, angiography has been shown to underestimate the presence and severity of TCAV (20). Intravascular ultrasound imaging (IVUS) has been proposed as a more sensitive means of detecting intimal vascular wall thickening and may be an important tool for ensuring optimal stent deployment, reducing stent under-expansion, incomplete stent apposition, edge dissection or geographic miss (30).…”

Section: Discussionmentioning

confidence: 99%

Percutaneous coronary intervention versus coronary artery bypass grafting in heart transplant recipients with coronary allograft vasculopathy: a systematic review and meta-analysis of 1,520 patients

Luc¹,

Choi²,

Rizvi³

et al. 2018

Ann. Cardiothorac. Surg.

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CABG and PCI are both feasible modalities for revascularization in patients with TCAV where PCI is associated with lower mortality. There were no differences in outcomes among patients who underwent PCI with DES as compared to BMS. Potential bias may exist due to heterogeneity in available data. Further studies are needed to delineate evidence-based guidelines to tailor the appropriate therapy, CABG or PCI, to the appropriate patient.

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“…In addition, both IVUS and IVOCT have limited sensitivity for studying chemical composition and quantifying tissue mechanical properties, which are key indicators of plaque vulnerability [121][122][123][124]. To obtain the chemical composition of a plaque, intravascular NIRF and NIRS capable of providing molecular contrast with high sensitivity have been applied to characterize the intralesion lipid content, but these techniques lack depth information [125][126][127][128][129]. Conversely, intravascular PA (IVPA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of US imaging [50,130,131], which can map blood vessel wall and lipid content simultaneously.…”

Section: Intravascular Applicationmentioning

confidence: 99%

Advances in Endoscopic Photoacoustic Imaging

Zhou

et al. 2021

Photonics

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Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong light scattering and attenuation. Endoscopic PA technology enables direct delivery of excitation light into the interior of a hollow organ or cavity of the body for functional and molecular PA imaging of target tissue. Various endoscopic PA probes have been developed for different applications, including the intravascular imaging of lipids in atherosclerotic plaque and endoscopic imaging of colon cancer. In this paper, the authors review representative probe configurations and corresponding preclinical applications. In addition, the potential challenges and future directions of endoscopic PA imaging are discussed.

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Multimodality Intracoronary Imaging With Near-Infrared Spectroscopy and Intravascular Ultrasound in Asymptomatic Individuals With High Calcium Scores

Cited by 13 publications

References 28 publications

Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression

Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression

Percutaneous coronary intervention versus coronary artery bypass grafting in heart transplant recipients with coronary allograft vasculopathy: a systematic review and meta-analysis of 1,520 patients

Advances in Endoscopic Photoacoustic Imaging

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