2020
DOI: 10.1016/j.nucmedbio.2019.11.002
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Multimodality labeling strategies for the investigation of nanocrystalline cellulose biodistribution in a mouse model of breast cancer

Abstract: Methods-We have developed a nuclear and fluorescence labeling strategy for nanocrystalline cellulose (CNC), an emerging biomaterial with versatile chemistry and facile preparation from renewable sources. We modified CNC through 1,1′-carbonyldiimidazole (CDI) activation with radiometal chelators desferrioxamine B and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), allowing for the labeling with zirconium-89 (t ½ = 78.41 h) and copper-64 (t ½ = 12.70 h), respectively, for non-invasive positron emission tomo… Show more

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Cited by 13 publications
(10 citation statements)
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“…The construction of such dual imaging tools involving a molecular vector, a BFCA, and a fluorescent dye follows either the dual imaging dye or the iterative approaches (Figures and ). The simultaneous approach (one-pot mix of a molecular vector, radiometals, and fluorescent dye), being sparsely described for molecular tools, , will not be detailed here. Dual PET/fluorescence molecular agents described in the literature are listed in Table .…”
Section: Dual Pet/fluorescence Imaging Tools: Variety Of Examplesmentioning
confidence: 99%
“…The construction of such dual imaging tools involving a molecular vector, a BFCA, and a fluorescent dye follows either the dual imaging dye or the iterative approaches (Figures and ). The simultaneous approach (one-pot mix of a molecular vector, radiometals, and fluorescent dye), being sparsely described for molecular tools, , will not be detailed here. Dual PET/fluorescence molecular agents described in the literature are listed in Table .…”
Section: Dual Pet/fluorescence Imaging Tools: Variety Of Examplesmentioning
confidence: 99%
“…Direct injection of replication-competent virus will destroy the host cells. Therefore, VLPs serving as alternatives for construction of drug delivery systems have been developed. Virus assembly such as TMV assembly is induced by the origin of assembly (OAS).…”
Section: Applications Of Virus or Viruslike Structuresmentioning
confidence: 99%
“…This can be achieved with fluorescence microscopy techniques if the nanocelluloses are fluorescent, as the sensitivity and specificity of these methods permit visualizing nanoparticles and nanofibers within complex 3D systems. A previous study has shown that the uptake of fluorescent CNCs by macrophage and embryonic cells can be monitored, and their biodistribution within tissues is visualized when they are used as drug delivery vehicles. The distribution of CNCs and their interactions with components in new biocomposite materials, such as structured CNC-polymer hydrogels and CNC-protein-polymer matrices, have been reported through confocal microscopy. , Fluorescent cellulose has also been used to study the impact of pretreatments on the structure, accessibility, and enzymatic depolymerization of cellulose with very high resolution, contributing to the development of efficient biomass conversion strategies. Yet, advanced imaging methods like light-sheet, multiphoton, or super-resolution microscopy are rarely applied to cellulose studies. This is partly due to a lack of simple, efficient, and cost-effective methods to fluorescently tag nanocelluloses without altering their unique properties.…”
Section: Introductionmentioning
confidence: 99%