Multimodality therapy for metastatic sarcomas confined to the lung

Gollard, Russell; Turner, J. Francis

doi:10.3892/ol.2012.820

Cited by 2 publications

(3 citation statements)

References 67 publications

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“…This is because lung tissue may be destroyed at the radiation levels required for sarcoma treatment. 8 The use of supplemental chemotherapy may be appropriate based on tumor histology, location, and size but should be given as neoadjuvant therapy to help make surgical resection volume smaller. 6 Similar to lung metastases, additional surgical resection may be permissible in the treatment of metastatic disease to the liver, although overall outcomes tend to remain poor and are limited to level III and IV evidence.…”

Section: Differences In the Treatment Approachmentioning

confidence: 99%

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Challenges in the Management of Complex Soft-Tissue Sarcoma Clinical Scenarios

Blank,

Fice

2023

J Am Acad Orthop Surg

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With nearly 15,000 new cases of soft-tissue sarcoma (STS) in the United States each year, early diagnosis and therapeutic management is imperative for successful patient outcomes. Primary STS is conventionally treated with a combination of wide-margin resection, neoadjuvant or adjuvant radiation therapy, and, in specific cases, adjuvant chemotherapy. However, in situations of complex disease presentation, guidelines for treatment are less clearly outlined. Limited metastatic disease, local recurrence, fungating STSs, and unplanned or incomplete resections of STSs present unique challenges for the multidisciplinary care team. The management of complex STS clinical scenarios usually involves limb-salvage resection or amputation as well as some combination of radiation therapy and/or ablative interventional radiology techniques. As a result, a multidisciplinary team approach is essential for treating patients in these challenging scenarios, with a recent focus on the integration of plastic and reconstructive surgery into the treatment algorithm.

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Section: Differences In the Treatment Approachmentioning

confidence: 99%

Section: Limited Metastatic Diseasementioning

confidence: 99%

Challenges in the Management of Complex Soft-Tissue Sarcoma Clinical Scenarios

Blank,

Fice

2023

J Am Acad Orthop Surg

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“…Osteosarcoma, a bone sarcoma, is the eighth most common malignancy occurring in all age groups, the prevalence of which is 20% in adolescents and 5% in children ( 1 , 2 ). Bone sarcomas are generally derived from the mesenchymal or non-epithelial tissues and predominantly occur as a high-grade tumor with pulmonary metastases ( 3 ). Following diagnosis, the average life span of patients with bone sarcoma at the metastasis stage is <5 years ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

Aberrant Wnt/β-catenin signaling and elevated expression of stem cell proteins are associated with osteosarcoma side population cells of high tumorigenicity

Zhao

Qiao

et al. 2015

Molecular Medicine Reports

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According to the cancer stem cell theory, the presence of a small sub-population of cancer cells, termed cancer stem cells (CSCs), have a significant implication on cancer treatment and are responsible for tumor recurrence. Previous studies have reported that alterations in the Wnt/β-catenin signaling are crucial in the maintenance of CSCs. In the present study, the characteristic features and activation of Wnt/β-catenin signaling in CSCs from osteosarcoma, an aggressive human bone tumor, were investigated. In total, ~2.1% of the cancer stem-like side population (SP) cells were identified in the osteosarcoma samples. The results of subsequent western blot and reverse transcription-quantitative polymerase chain reaction analyses revealed that the protein levels of β-catenin and cyclin D1 were markedly upregulated in the fluorescence-activated cell sorted osteosarcoma SP cells. In addition, the elevated expression levels of stem cell proteins, including CD133, nestin Oct-4, Sox-2 and Nanog were significantly higher in the SP cells, which contributed to self-renewal and enhanced the proliferation rate of the SP cells. Furthermore, the SP cells were found to be highly invasive and able to form tumors in vivo. Taken together, these data suggested that the identification of novel anticancer drugs, which suppress the Wnt/β-catenin signaling and its downstream pathway may assist in eradicating osteosarcoma stem cells.

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Multimodality therapy for metastatic sarcomas confined to the lung

Cited by 2 publications

References 67 publications

Challenges in the Management of Complex Soft-Tissue Sarcoma Clinical Scenarios

Challenges in the Management of Complex Soft-Tissue Sarcoma Clinical Scenarios

Aberrant Wnt/β-catenin signaling and elevated expression of stem cell proteins are associated with osteosarcoma side population cells of high tumorigenicity

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