Multimodality Therapy in Early-Stage Neuroendocrine Carcinoma of the Uterine Cervix

Boruta, David M.; Schorge, John O.; Duska, Linda; Crum, Christopher P.; Castrillón, Diego H.; Sheets, Ellen E.

doi:10.1006/gyno.2000.6118

Cited by 93 publications

(61 citation statements)

References 19 publications

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“…A total of 82 early-stage SCCUC patients who had undergone SU with or without adjuvant therapy were identified by a search on PubMed (3,4,9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The total number of patients for analysis was 96.…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors and treatment comparison in early-stage small cell carcinoma of the uterine cervix

2011

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Abstract. Small cell carcinoma of the uterine cervix (SCCUC) is rare and its biologic behavior is aggressive. To analyze prognostic factors and determine optimal therapy in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB1-IIA SCCUC, we retrospectively reviewed 96 patients (14 patients treated in our center and 82 patients identified by a search on PubMed) treated with radical surgery (SU), surgery plus adjuvant chemotherapy (SU+Chemo), or surgery plus adjuvant chemotherapy and radiotherapy (SU+Chemo+RT) between 1990 and 2010. Of the 96 patients, 11 patients were treated with SU, 33 with SU+Chemo, and 52 with SU+Chemo+RT. The 5-year survival rate for the 96 patients was 45%. A total of 6% (2/32) of patients had local recurrence, 75% (24/32) had distant metastases, and 19% (6/32) had both. The 5-year survival rate in stage IB1 and IB2-IIA disease was 58 and 34%, respectively (P=0.049). For patients with and without lymph node metastases (LNM), survival was 33 and 60%, respectively (P=0.045). Patients with inner 1/3 stromal invasion had a better survival than those with deep stromal invasion (DSI) (100 vs. 34%, P=0.003). Survival was not significantly different in patients treated with the above three modalities, albeit treatment selection was related to LNM (P=0.000) and DSI (P=0.027). Thus, FIGO stage, LNM and DSI are significant predictors of survival. Adjuvant therapy after SU has not improved survival compared with surgery alone. Thus, newer multimodality therapy should be evaluated.

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Section: Resultsmentioning

confidence: 99%

Prognostic factors and treatment comparison in early-stage small cell carcinoma of the uterine cervix

2011

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“…Many authors have recommended adjuvant chemotherapy due to the aggressive behavior of this tumor (Chang et al 1998;Boruta et al 2001); however, it is difficult to perform a large scale randomized controlled study given the rarity of the condition. The Gynecologic Oncology Group attempted to study small cell cervical carcinoma in protocol 66 between 1982 and 1986, but failed to recruit sufficient numbers of patients.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Carcinoma of the Uterine Cervix: Clinical Outcome of Concurrent Chemoradiotherapy with a Multidrug Regimen

Tokunaga¹,

Nagase²,

Yoshinaga³

et al. 2013

Tohoku J. Exp. Med.

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“…In general, survival is poor with radical hysterectomy alone, but there is no consensus as to optimal management [9]. Treatment considerations have been largely extrapolated from the experience with small cell lung cancer [10]. Most clinicians favor the use of combined modality therapy (surgery followed by chemotherapy or combined chemoradiotherapy) for limited-stage potentially resectable disease, definitive chemoradiotherapy for locoregionally advanced unresectable but nonmetastatic disease, and palliative chemotherapy alone for those with metastatic disease, using chemotherapy regimens that are typically used for small cell lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Large Cell Neuroendocrine Carcinoma of Female Genital Tract: A Clinicopathological Study of Two Cases with Review of Literature

Prakasam

Hussain

et al. 2013

Indian J Surg Oncol

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Multimodality Therapy in Early-Stage Neuroendocrine Carcinoma of the Uterine Cervix

Cited by 93 publications

References 19 publications

Prognostic factors and treatment comparison in early-stage small cell carcinoma of the uterine cervix

Prognostic factors and treatment comparison in early-stage small cell carcinoma of the uterine cervix

Small Cell Carcinoma of the Uterine Cervix: Clinical Outcome of Concurrent Chemoradiotherapy with a Multidrug Regimen

Large Cell Neuroendocrine Carcinoma of Female Genital Tract: A Clinicopathological Study of Two Cases with Review of Literature

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