Wireless technology plays a vital role in the Electronic health (e‐health) applications such as telemedicine and remote patient monitoring. One of the major challenges of telemedicine applications is ensuring adequate quality of service and realizing precise diagnosis. Telemedicine employs image fusion to enhance the quality of medical image for better diagnosis. However, the transmission of medical image needs high data rate and bandwidth. Due to the robustness to multipath fading, high data rate transmission capability, high flexibility, high bandwidth efficiency, and easy implementation using fast Fourier transform, an orthogonal frequency division multiplexing (OFDM) is the suitable technique for medical image transmission in telemedicine applications This paper is focused on improving the quality of the fused brain image transmission over OFDM based telemedicine service using comb type pilot based carrier frequency offset compensation. The simulation results show that the proposed method offers better performance in terms of mean squared error, Euclidean distance, peak signal to noise ratio, bit error rate, carrier to interference ratio, and computational complexity.