Multipathogen infections in hospitalized children with acute respiratory infections

Peng, Dan; Zhao, Dongchi; Liu, Jianwen; Wang, Xia; Yang, Kun; Hong, Xuebao; Li, Yang; Wang, Xinghuan

doi:10.1186/1743-422x-6-155

Cited by 107 publications

(133 citation statements)

References 25 publications

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“…Infections with multiple pathogens have been reported in hospitalized children with acute respiratory infection [24]. Viral coinfection occurred predominantly in August and was more frequent in children between 3 and 6 years old.…”

Section: Discussionmentioning

confidence: 99%

Characteristic findings of pediatric inpatients with pandemic (H1N1) 2009 virus infection among severe and nonsevere illnesses

Okada

Morozumi

Matsubara

et al. 2011

Journal of Infection and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Characteristic findings of pediatric inpatients with pandemic (H1N1) 2009 virus infection among severe and nonsevere illnesses

Okada

Morozumi

Matsubara

et al. 2011

Journal of Infection and Chemotherapy

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“…Despite the wide use of antibiotics, bacterial infection was confirmed in only one patient. However, viral coinfection was detected in 20% of the adenovirus positive samples, which, accordingly, previous reports may have contributed to high hospital admission rates 2,5,25 .…”

mentioning

confidence: 83%

Adenovirus respiratory infection: significant increase in diagnosis using PCR comparing with antigen detection and culture methods

Stroparo

Cruz

Debur

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAdenovirus (AdV) respiratory infections are usually described as being associated with high mortality rates. Laboratory diagnosis is essential for the establishment of the appropriate therapy, and for guiding the implementation of preventive measures in order to prevent the spread of the infection. Aiming to analyze the sensitivity and specificity of the laboratorial diagnosis methods available, we compared antigen detection by indirect immunofluorescence assay (IF), and a specific nested polymerase chain reaction (PCR), to detect AdV in respiratory samples collected from patients admitted to hospital with acute respiratory disease. Positive samples were inoculated into a cell culture to confirm the results. We analyzed 381 samples from the nasopharyngeal aspirates collected during the year 2008; of these, 2.6% tested were positive for adenovirus through IF and 10% through PCR; positive isolation was obtained in 40% and 26% of these cases, respectively. Most infected patients were children under six months of age, and despite of the fact that a significant number of patients required intensive care, the mortality rate was low (5%). In conclusion, molecular methods were found to be useful for rapid diagnosis of adenovirus infections with higher sensitivity than antigen detection; their introduction permitted a significant increase in diagnoses of adenovirus infections.

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“…However, incidences of adenovirus-associated illnesses are higher among children than among adults. As such, in China, the impact of HAdVs on respiratory infection is well characterized in children [10][11][12][13][14][15] but not in adults.…”

Section: Introductionmentioning

confidence: 99%

Detection of three human adenovirus species in adults with acute respiratory infection in China

Guo

Gonzalez

Zhou

et al. 2011

Eur J Clin Microbiol Infect Dis

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Human adenoviruses (HAdVs) are recognized as causal agents in a wide range of human diseases. However, researchers lack sufficient data on the exact HAdV species and serotypes associated with adult acute respiratory tract infections (ARTIs). To detect and characterize HAdV infections in adults in China, clinical specimens were collected from 10,310 adults with ARTIs from May 2005 to July 2010. The partial HAdV hexon gene was amplified by polymerase chain reaction (PCR), sequenced, and phylogenetically analyzed. HAdVs were detected in 86 samples (0.8%), of which 67 (77.9%) were species B (HAdV-3, -7, -11, and -14), 7 (8.1%) were species C (HAdV-1, -2, and -6), and 12 (14%) were species E (HAdV-4). HAdV-3 was the most frequently detected serotype (41/86, 47.7%), followed by HAdV-7 (13/86, 15.1%), HAdV-4 (12/86, 14.0%), and HAdV-11 (11/86, 12.8%). Patients 14-25 years old (60.5%) exhibited a higher rate of adenovirus detection than older patients. Co-infections with other respiratory viruses were observed in samples positive for HAdV species B and E. Human rhinovirus was the most commonly found virus in patients with HAdV infection. These findings provide baseline data for the surveillance and control of HAdV infection in China.

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Multipathogen infections in hospitalized children with acute respiratory infections

Cited by 107 publications

References 25 publications

Characteristic findings of pediatric inpatients with pandemic (H1N1) 2009 virus infection among severe and nonsevere illnesses

Characteristic findings of pediatric inpatients with pandemic (H1N1) 2009 virus infection among severe and nonsevere illnesses

Adenovirus respiratory infection: significant increase in diagnosis using PCR comparing with antigen detection and culture methods

Detection of three human adenovirus species in adults with acute respiratory infection in China

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