Multiphase versus Single Pot Granulation Process: Influence of Process and Granulation Parameters on Granules Properties

Giry, Karine; Genty, Muriel; Viana, Marylène; Wüthrich, Patrick; Chulia, Dominique

doi:10.1080/03639040500529119

Cited by 22 publications

(8 citation statements)

References 81 publications

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“…As discussed by K. Giry et al [20] in practice switching from one granulation equipment to another may be necessary to comply with available production equipment. Granulation runs for a low viscosity and a high viscosity binder has been carried out on the 6 L Diosna HSM.…”

Section: Effect Of Mixer Designmentioning

confidence: 99%

Wet granulation in laboratory scale high shear mixers: Effect of binder properties

2011

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a b s t r a c t Keywords:High shear mixer granulator Torque curves Work of adhesion Viscosity Scale-up The effect of binder properties on torque curves, granule growth kinetics, wet mass consistency and dry granule strength has been investigated in this study. Granulation runs have been performed on a fine cohesive microcrystalline cellulose powder (Avicel 105, d 50 = 20 μm) in two types of laboratory high shear mixers: a MiPro high shear mixer using a 1.9 L bowl and a 6 L Diosna high shear mixer. Binders used included ultra-pure water and solutions of varying concentrations of PVP and HPMC allowing us to cover different values for parameters like viscosity and work of adhesion. Torque curves recorded during granulation are found to allow good control of the process. Optimum liquid requirement for granulation has been found to vary with binder type and decrease with increasing viscosity while granule growth kinetics has been found to be to be related to the work of adhesion for low viscosity binders. Granule strength has been evaluated for wet granules by the means of wet mass consistency measurements on a mixer torque rheometer and for dried granules by means of uniaxial compression tests on a Texture Analyser mechanical testing machine. For low viscosity binders both wet mass consistency and dry granule strength have been found to depend on the work of adhesion. For high viscosity binders higher wet mass consistencies but lower dry granule strengths have been observed. Granulating on the larger 6 L scale has shown that constant impeller tip speed offers good agreement in terms of mean granule size however granule size distribution seems to be scale dependant.

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Section: Effect Of Mixer Designmentioning

confidence: 99%

Wet granulation in laboratory scale high shear mixers: Effect of binder properties

2011

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“…This material is introduced into a newly innovated fractionating device that separates the granules and recycles rejected fraction. [24][25][26][27][28] Advantages…”

Section: Pneumatic Dry Granulation (Pdg)mentioning

confidence: 99%

Novel Techniques of Granulation: A Review

Muralidhar¹,

Bhargav²,

Sowmya³

2016

Int. Res. J. Pharm.

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Granulation is an important unit process in the production of pharmaceutical dosage forms like tablets, capsules and other dosage forms. Granulation process increases flow, compressibility and content uniformity of the powders. It inhibits the separation of blend components and reduces excessive amount of fine particles. This process helps to achieve improved yields with less tablet manufacturing defects. Particle size of granules depends on the quantity and feeding rate of the granulating liquid. Selecting a method of granulation requires comprehensive study of each ingredient in the formula, the combination of ingredients and their compatibility with each other is checked after, which appropriate granulation process can be applied. The recent technologies used for granulation include steam granulation, moisture activated dry granulation (MADG), moist granulation technique (MGT), extrusion-spheronization granulation, fluidized bed granulation, thermal adhesion granulation process (TAGP) and foam granulation etc. have their own advantages and overcome the disadvantages of conventional granulation process such as dust generation or deteriorating effect of heat as drying step. The objective of present work is to focus on the novel granulation technologies.

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“…Many difficulties are likely to arise due to the numerous process and formulation parameters which must be taken into account. Considering these parameters is therefore of high importance to maintain quality in case of equipment changes 5…”

Section: Introductionmentioning

confidence: 99%

Comparison of Single Pot and Multiphase High Shear Wet Granulation Processes Related to Excipient Composition

Giry

Viana

Genty

et al. 2009

Journal of Pharmaceutical Sciences

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Multiphase versus Single Pot Granulation Process: Influence of Process and Granulation Parameters on Granules Properties

Cited by 22 publications

References 81 publications

Wet granulation in laboratory scale high shear mixers: Effect of binder properties

Wet granulation in laboratory scale high shear mixers: Effect of binder properties

Novel Techniques of Granulation: A Review

Comparison of Single Pot and Multiphase High Shear Wet Granulation Processes Related to Excipient Composition

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