Multiple Abnormalities in Glucose and Energy Metabolism and Coordinated Changes in Levels of Adiponectin, Cytokines, and Adhesion Molecules in Subjects With Metabolic Syndrome

Salmenniemi, Urpu; Ruotsalainen, Eija; Pihlajamäki, Jussi; Vauhkonen, Ilkka; Kainulainen, Sakari; Punnonen, Kari; Vanninen, Esko; Laakso, Markku

doi:10.1161/01.cir.0000150391.38660.9b

Cited by 238 publications

(174 citation statements)

References 34 publications

(43 reference statements)

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“…29 Serum level of hsCRP, a marker of systemic inflammation, was more strongly related with MeS than other inflammatory biomarkers in regard not only to the number of components but also to their clustering, in agreement with previous reports in general population. 34,35 However, another study did not found significant relation between hsCRP and incidence of MeS in HD patients, may be due to lower sample size. 3 Serum level of hsCRP was significantly positively correlated with FPG and HbA1c, and negatively with HDL-C levels.…”

Section: Discussionmentioning

confidence: 93%

Association of Inflammatory Biomarkers with Metabolic Syndrome in Hemodialysis Patients

et al. 2012

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The relative importance of inflammatory markers in relation with metabolic syndrome (MeS) in hemodialysis (HD) patients is uncertain. This study investigated the association between MeS and high-sensitive C-reactive protein (hsCRP), hallmark of inflammation, and other inflammatory-related biomarkers. The study included 153 patients who were dialyzed at least for the last 3 months. The serum level of hsCRP was assessed by high-sensitive Enzyme-linked immunosorbent assay (ELISA). MeS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III (ATP-III). Ninety-one HD patients (59.5%) were diagnosed as having MeS. Lower level of high-density lipoproteincholesterol (HDL-C) was the most prevalent MeS component (85.6%). The serum level of hsCRP in these patients was significantly higher than that in HD patients without MeS (2.3 AE 1.7 vs. 1.7 AE 1.6 mg/dL, p ¼ 0.03). A significant linear increase in the hsCRP levels was found according to the number of MeS components (β ¼ 0.09, p ¼ 0.022). The study concluded that increasing inflammatory biomarkers, especially hsCRP, is associated with MeS in HD patients.

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Section: Discussionmentioning

confidence: 93%

Association of Inflammatory Biomarkers with Metabolic Syndrome in Hemodialysis Patients

et al. 2012

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“…First, an IVGTT was performed to determine the first-phase insulin secretion capacity [18] as previously described [16]. Immediately after an IVGTT, the degree of insulin resistance was evaluated by the euglycaemic clamp technique [19].…”

Section: Methodsmentioning

confidence: 99%

“…Genetically the Finnish population is relatively homogeneous, originating mainly from southern (European) and eastern (Asian) immigration about 2,000 years ago [15]. The study group consisted of 158 non-diabetic offspring of patients with type 2 diabetes from our ongoing study [16]. Patients with type 2 diabetes were randomly selected from patients living in the Kuopio University Hospital region (population of 250,000).…”

Section: Study Imentioning

confidence: 99%

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes

et al. 2006

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Aims/hypothesis: The mechanisms by which the calpain-10 gene (CAPN10) affects the risk of type 2 diabetes are unclear. Therefore, we investigated the effects of four polymorphisms in CAPN10 (single nucleotide polymorphism [SNP]-43, SNP-44, Insertion/Deletion [Indel]-19 and SNP-63) on insulin secretion, insulin action and abdominal fat distribution in offspring of patients with type 2 diabetes. Subjects and methods: Insulin secretion was determined by an IVGTT, insulin action by the hyperinsulinaemic-euglycaemic clamp and abdominal fat distribution by computed tomography in 158 non-diabetic offspring (age 34.9±6.3 years [mean±SD], BMI 26.2± 4.9 kg/m 2 ) of type 2 diabetic patients. Results: SNP-43 (p=0.009 over the three genotypes, adjusted for age, sex, BMI and family relationship) and haplotypes carrying the A allele of SNP-43 were associated with intra-abdominal fat area. The A allele of SNP-43 was associated with intraabdominal fat area in men (p=0.014) but not in women. were not associated with intra-abdominal fat area or insulin action. Furthermore, we demonstrated in a separate sample of middle-aged men (n=234) who had a history of type 2 diabetes in firstdegree relatives that the A allele of SNP-43 was associated with a large waist circumference, and high insulin levels in an OGTT.Conclusions/interpretation: SNP-43 of CAPN10 may contribute to the risk of diabetes by regulating abdominal obesity in subjects with high risk of type 2 diabetes.

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“…Cross-sectional studies link decreased adiponectin levels with several metabolic traits, including insulin resistance, dyslipidemia, and the metabolic syndrome [2,4,5]. Moreover, low levels of adiponectin predict future development of diabetes [6], cardiovascular disease [7] and obesity-associated malignancies [8,9].…”

Section: Brief Communication (Original)mentioning

confidence: 99%

Adiponectin response to supervised aerobic training in type II diabetic patients

2014

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Background:Cross-sectional studies have linked decreased adiponectin levels with several metabolic traits, including insulin resistance, dyslipidemia, and metabolic syndrome. Previous studies conducted to investigate the effects of acute or chronic exercise on the serum adiponectin have produced conflicting and controversial results. Objective: To investigate the effect of supervised aerobic training of moderate intensity on the total serum levels of adiponectin and its relationship to insulin resistance and body weight in subjects with type 2 diabetes (DM2). Methods: Thirty-five patient participants diagnosed as having DM2 mellitus for more than 5 years with normal or near normal body weight took part in this study. The diagnosis of DM was based on the American Diabetes Association criteria for type 2 diabetes mellitus. Serum levels of blood glucose, insulin, total adiponectin, high molecular weight adiponectin, and insulin resistance were determined before and after a 12-week program of supervised moderate intensity aerobic training. Results: Twelve weeks of supervised moderate intensity aerobic training produced a significant reduction of fasting blood sugar, fasting insulin, glycosylated hemoglobin, and insulin resistance in male subjects with DM2. By contrast, a significant increase in the total serum adiponectin and high molecular weight adiponectin has been reported. There was no significant correlation between the reduction of the body mass index, insulin resistance, and the increase of the total serum adiponectin or high molecular weight adiponectin. Conclusion: Prolonged exercise training of at least moderate intensity improves levels of adiponectin and insulin sensitivity in men with type 2 diabetes.

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Multiple Abnormalities in Glucose and Energy Metabolism and Coordinated Changes in Levels of Adiponectin, Cytokines, and Adhesion Molecules in Subjects With Metabolic Syndrome

Cited by 238 publications

References 34 publications

Association of Inflammatory Biomarkers with Metabolic Syndrome in Hemodialysis Patients

Association of Inflammatory Biomarkers with Metabolic Syndrome in Hemodialysis Patients

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes

Adiponectin response to supervised aerobic training in type II diabetic patients

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