Multiple antigenic peptide (MAP): a synthetic peptide dendrimer for diagnostic, antiviral and vaccine strategies for emerging and re-emerging viral diseases

Joshi, Vinay G.; Dighe, Vikas; Thakuria, Dimpal; Malik, Yashpal Singh; Kumar, Satish

doi:10.1007/s13337-013-0162-z

Cited by 59 publications

(40 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The peptidodendrimer inhibited both HSV-1 and HSV-2 at the initial phases of the entry process, probably by interacting with the glycoproteins that form the viral envelope, thus precluding the virus from closely approaching the cellular membranes, a necessary prerequisite of viral internalization [39]. For other virus-related applications of synthetic peptide dendrimers, for example as diagnostic tools and for the development of vaccines, interested readers are directed to a recently published review [41]. …”

Section: Viruses and Fungal Pathogens As Targetsmentioning

confidence: 99%

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

Scorciapino

Serra

Manzo

et al. 2017

IJMS

View full text Add to dashboard Cite

Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These intriguing novel compounds, generally made of multiple peptidic sequences linked to an inner branched core, display an array of antibacterial, antiviral and antifungal activities, usually coupled to low haemolytic activity. In addition, several peptides synthesized in oligobranched form proved to be promising tools for the selective treatment of cancer cells.

show abstract

Section: Viruses and Fungal Pathogens As Targetsmentioning

confidence: 99%

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

Scorciapino

Serra

Manzo

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…While, the receiving immunological response because of single peptide immunization is a kind of challenge. Nevertheless, the use of a MAP system in vaccine strategies seems to be more appropriate because of the higher immunological response, low probability of an immune response to the dendrimer's matrix, and its high resistance to proteolysis and degradation . And even though the produced antibodies failed to suppress hCC dimerization, we hope that our results might appear helpful in the development of therapies related to the suppression of neurodegenerative diseases, such as HCCAA.…”

Section: Discussionmentioning

confidence: 90%

Identification and characterization of antibodies elicited by human cystatin C fragment

Behrendt

Prądzińska

Spodzieja

et al. 2017

J of Molecular Recognition

View full text Add to dashboard Cite

Amyloid formation is associated with a number of neurodegenerative diseases that affect the independence and quality of life of aging populations. One of rather atypical, occurring at a young age amyloidosis is hereditary cystatin C amyloid angiopathy (HCCAA) related to aggregation of L68Q variant of human cystatin C (hCC). Human cystatin C plays a very important role in many aspects of human health; however, its amyloidogenic properties manifested in HCCAA present a real, lethal threat to some populations and any work on factors that can affect possible influencing hCC aggregation is not to overestimate. It was proved that interaction of hCC with monoclonal antibodies suppresses significantly hCC dimerization process. Therefore, immunotherapy seems to be the right approach toward possible HCCAA treatment. In this work, the hCC fragment encompassing residue 60-70 (in 2 variants: linear peptide and multiple antigenic peptide) was used as an immunogen in rabbit immunization. As a result, specific anti-hCC antibodies were found in both rabbit sera. Surprisingly, rabbit antibodies were obtained after immunization with only a short peptide. The obtained antibodies were characterized, and their influence on the aggregation propensity of the hCC molecules was evaluated. The antibodies turned out not to have any significant influence on the cystatin C dimerization process. Nevertheless, we hope that antibodies elicited in rabbits by other hCC fragments could lead to elaboration of effective treatment against HCCAA.

show abstract

“…MAP dendrimers may have more than one different epitopes in the serodiagnosis of hepatitis C virus. 64,65 Additionally, those dendrimers, acting as biosensors, could be used as probes to detect bioorganic compounds. 64…”

Section: Diagnostic Biosensor and Nanodiagnosticsmentioning

confidence: 99%

Peptide dendrimers: drug/gene delivery and other approaches

et al. 2017

View full text Add to dashboard Cite

Dendrimers are versatile hyperbranched molecules, which have deserved attention especially for their potential in many applications, including biological. Peptide dendrimers comprise interesting classes of dendrimers, and their use has been emphasized as a drug/bioactive compound delivery system, mostly in the antineoplastic area. The bioactive molecules can be covalently linked or entrapped inside the peptide derivative. Self-assembled nanocarriers are a recent trend in the design of potential delivery systems, and pH-sensitive carriers, one of their methods, have been designed to control their systems. In addition, the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems. Recent examples have been given in the literature, showing that gene delivery as another important peptide dendrimer application. It is worth emphasizing that some peptide dendrimers show activity per se, without bioactive compounds. Immune compounds and vaccines are presented herein, as well as uses of other peptide dendrimers are briefly discussed in this review, which encompasses around 10 years of work.

show abstract

Multiple antigenic peptide (MAP): a synthetic peptide dendrimer for diagnostic, antiviral and vaccine strategies for emerging and re-emerging viral diseases

Cited by 59 publications

References 60 publications

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

Identification and characterization of antibodies elicited by human cystatin C fragment

Peptide dendrimers: drug/gene delivery and other approaches

Contact Info

Product

Resources

About