Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test

Fitzgerald, Paul J.; Hale, Pho J.; Ghimire, Anjesh; Watson, Brendon O.

doi:10.1016/j.bbr.2021.113323

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Galantamine, rivastigmine and physostigmine were also tested in mice. The mice were exposed to FST and OFT [340]. This study concluded that these drugs may be effective for treating MDD, but their effects are dose-dependent.…”

Section: The Use Of Ache Inhibitors For Mdd and Bpadmentioning

confidence: 96%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

118

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Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that can prevent the occurrence of neurodegenerative diseases and slow down their course. The aim of this review is to present the role of AChE in the pathomechanism of neurodegenerative diseases. In addition, this review aims to reveal the benefits of using AChE inhibitors to treat these diseases. The selected new AChE inhibitors were also assessed in terms of their potential use in the described disease entities. Designing and searching for new drugs targeting AChE may in the future allow the discovery of therapies that will be effective in the treatment of neurodegenerative diseases.

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Section: The Use Of Ache Inhibitors For Mdd and Bpadmentioning

confidence: 96%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

118

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“…Acetylcholine is a neurotransmitter in the body that is rapidly hydrolyzed in tissues by cholinesterase to form acetate and choline, which can block nerve signals. In 1792 Janowsky proposed the hypothesis of hypercholinergic-adrenergic dysfunction as the pathogenesis of depression, and recent studies have shown that various cholinesterase inhibitors have antidepressant-like properties in the forced swimming test in mice [ 74 , 75 ]. Furthermore, acetylcholine deficiency is a major cause of AD, and acetylcholinesterase inhibitors improve cognitive function in patients with cognitive impairment.…”

Section: Mechanism Of Action Of Aeo In the Treatment Of Mental Illnessmentioning

confidence: 99%

Chemical Composition and Potential Properties in Mental Illness (Anxiety, Depression and Insomnia) of Agarwood Essential Oil: A Review

Chen

Wang

et al. 2022

Molecules

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As a valuable medicinal herb and spice, agarwood is widely used in the fields of daily chemistry, traditional medicine, religion and literary collection. It mainly contains sesquiterpenes and 2-(2-phenylethyl)chromones, which are often used to soothe the body and mind, relieve anxiety, act as an antidepressant and treat insomnia and other mental disorders, presenting a good calming effect. This paper reviews the chemical composition of the essential oils of different sources of agarwood, as well as the progress of research on the sedative and tranquilizing pharmacological activity and mechanism of action of agarwood essential oil (AEO), and then analyzes the current problems of AEO research and its application prospects in the treatment of mental diseases.

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Central cholinergic transmission affects the compulsive-like behavior of mice in marble-burying test

Patel,

Maturkar

et al. 2024

Brain Research

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Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test

Cited by 5 publications

References 49 publications

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Chemical Composition and Potential Properties in Mental Illness (Anxiety, Depression and Insomnia) of Agarwood Essential Oil: A Review

Central cholinergic transmission affects the compulsive-like behavior of mice in marble-burying test

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