Multiple cranial nerve neuropathies, ataxia and, areflexia: Miller Fisher syndrome in a child and review

Muñiz, Antonio E.

doi:10.1016/j.ajem.2016.07.042

Cited by 8 publications

(5 citation statements)

References 66 publications

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“…6,[8][9][10][11][12] When ataxia is the predominant clinical sign that is more often reported accompanied by ophthalmoplegia and areflexia, leading to the diagnosis of Miller-Fisher Syndrome (MFS). 13,14 In other cases, cranial nerve involvement and ataxia have been described as consistent with GBS syndrome. For example, Kuroki and Desai described a case of a 3-year-old girl with ataxia, facial droop, and dysarthric speech, 1 week after a gastrointestinal illness, who met the criteria for diagnosis of GBS with atypical features.…”

Section: Discussionmentioning

confidence: 96%

Subacute-Onset Afferent Ataxia in Childhood: A Case Report

Cecchin

Pellegrin

Parmeggiani

et al. 2019

Journal of Pediatric Neurology

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AbstractAcute or subacute ataxia in young children is rare and, in most cases, the diagnosis of the underlying etiology can be challenging. An extensive number of possible causes must be considered when approaching a child with ataxia. We report the case of a 21-month-old girl with subacute-onset rapidly progressive ataxia, occurring few days after a gastrointestinal infection, without clear reduction of muscle strength in the limbs or other neurological signs. The development of a mild hyporeflexia of the lower limbs, thereafter, led to the suspicion of a Guillain–Barré syndrome (GBS) that was confirmed by appropriate investigations. This case confirms that a subacute afferent ataxia can be the main clinical symptom of GBS in young children, in whom this disease is rare and the diagnosis more challenging. Attention must be paid to the presence of other neurological signs that can lead to the diagnosis.

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Section: Discussionmentioning

confidence: 96%

Subacute-Onset Afferent Ataxia in Childhood: A Case Report

Cecchin

Pellegrin

Parmeggiani

et al. 2019

Journal of Pediatric Neurology

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“…El MFS presenta en un 90% de los casos anticuerpos tipo IgG contra gangliósido anti-GQ1b (12) , por lo que un resultado positivo apoya certeramente el diagnóstico; sin embargo, hay otros parámetros de laboratorio concordantes con MFS como la disociación albumino citológica en LCR que puede aparecer tanto al inicio del cuadro como en la segunda o tercera semana de evolución y que se encuentra presente en un 65% de los casos. Estudios electrofisiológicos muestran un patrón de desmielinización en las vías nerviosas afectadas (13) .…”

Section: Discussionunclassified

“…El MFS es una enfermedad generalmente benigna y autolimitada; la mayoría de los pacientes resuelve completamente sus síntomas entre 8 y 12 semanas sin tratamiento (12) . El uso de inmunoglobulinas no afecta el pronóstico de los pacientes con MFS, pero sí podría acelerar la desaparición de los síntomas (16) .…”

Section: Discussionunclassified

Síndrome de Miller-Fisher en edad pediátrica: un debut inusual

Rai

et al. 2017

Rev. Hosp. Clín. Univ. Chile (En línea)

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Miller-Fisher syndrome is a peripheral neuropathy characterized by ophthalmoplegia, areflexia and ataxia. The incidence of this syndrome is estimated at 1 in a million, and just 14% of these occur on a pediatric age, making it an infrequent diagnosis in pediatrics. In this article we report a case of Miller-Fisher syndrome with an unusual onset on a pediatric patient along with infrequent radiological findings.

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“…No es pero ayuda para la confirmación. 6 Los resultados de los estudios electrofisiológicos muestran afectación nerviosa periférica como anomalías en las latencias motoras distales, velocidades de conducción motora o velocidades de conducción sensorial. 7 En el caso presentado se realizó el diagnóstico con base en la historia clínica, las manifestaciones clínicas, los hallazgos tomográficos y la disociación albuminocitológica, y se complementó con electromiografía.…”

Section: Wwwmedigraphicorgmxunclassified