Multiple cutaneous metaplastic synovial cysts

Singh, Sareeta R.; S.P., Alice; Dixon, Anita

doi:10.1016/s0190-9622(99)70378-6

Cited by 25 publications

(23 citation statements)

References 11 publications

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“…Most CMSCs reported by dermatologists were located on the extremities, whereas those described by other specialists tended to be distributed more globally. Associated conditions included Ehlers-Danlos syndrome, 3,10 rheumatoid arthritis (RA), 11,13 and basal cell carcinoma (BCC). 8 Characteristically, 17 cases of CMSC (59%) developed at the scar site of operations or trauma, and the time of evolution after operation or trauma was from a few weeks to years (range 3 weeks to 2 years); however, our patient did not have such a history.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Metaplastic Synovial Cyst: Case Report and Literature Review from the Dermatological Point of View

et al. 2016

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Cutaneous metaplastic synovial cysts (CMSCs) are rare tumors typically comprising a solitary, wellcircumscribed cystic mass that is not connected to the joint. Synovial cysts have been reported predominantly by orthopedists or pathologists; however, the presence of CMSC is not generally well recognized by dermatologists. Herein, we report a CMSC in a 68-year-old woman receiving systemic corticosteroid therapy for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). We attempt to delineate the clinical characteristics of this unusual neoplasm by reviewing the literature, focusing especially on dermatological descriptions. Histologic examination of the surgical specimen in the current case revealed that the cystic wall was lined with layers of flattened synovial cell-like cells and connective tissues, mimicking the synovial membrane. Positive immunoreactivity of the lining cells against vimentin was detected, but no immunoreactivity against cytokeratin, carcinoembryonic antigen (CEA), CD68, or S-100 was detected. The pathogenesis of CMSC remains unclear, but it has been tightly linked to direct traumatic stimuli or relative tissue fragility, which potentially accounts for CMSC development in our case. Most CMSCs reported by dermatologists are located on the extremities, whereas those described by other specialists tend to be distributed more globally. Preoperative diagnoses are often either epidermal cyst or suture/foreign body granuloma. Incomplete surgical excision of usual synovial cysts may lead to local recurrence, which has been reported in oral and maxillofacial surgery, but not in dermatologic surgery. This fact could be explained by the technical difficulties of surgical excision related to anatomical location. Dermatologists need to be aware of CMSC, and CMSC should be included in the differential diagnosis of subcutaneous cysts.

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Section: Discussionmentioning

confidence: 99%

“…11,13 Experimentally, normal synovium was formed by local mechanical disruption of the connective tissues in vivo. 20 Synovial cell-like cells can be differentiated from mesenchymal stem cells during the wound healing process.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metaplastic Synovial Cyst: Case Report and Literature Review from the Dermatological Point of View

et al. 2016

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“…Further, three of ten cases that have occurred spontaneously without local trauma were accompanied by Ehlers-Danlos syndrome3,10,12, which led us to believe that abnormal healing after microtrauma was a pathogenic mechanism of CMSC. Additionally, the fact that four cases of CMSC have accompanied rheumatoid arthritis6,9 and arthrosis10 suggested that chronic inflammation, constant pressure, and repeated manipulation have played critical roles in the pathogenesis of the lesions. Although the case presented in this report was a spontaneous case of CMSC that occurred without a history of trauma, it was believed to be caused by constant and chronic pressure since CMSC occurred in the first metatarsal head area, where heavy pressure was consistently applied.…”

Section: Discussionmentioning

confidence: 99%

“…CMSC lesions have been often misdiagnosed as suture granuloma given that the lesions are clinically associated with a surgical scar and observed as erythematous and painful subcutaneous nodules1,2,4,6,7. To this point, there have been two cases of multiple occurrences of CMSC6,11 and a single case of recurrent CMSC8.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metaplastic Synovial Cyst of the First Metatarsal Head Area

et al. 2011

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A cutaneous metaplastic synovial cyst (CMSC) is a cyst lined with metaplastic synovial tissue, which includes the formation of an intracystic villous structure resembling hyperplastic synovial villi. Clinically, the lesion is a tender, subcutaneous nodule that usually occurs at the site of previous surgical trauma and is frequently misdiagnosed as a suture granuloma. The actual cause remains unclear; however, trauma is presumed to be a precipitating factor, as most reported cases have demonstrated a history of antecedent cutaneous injury. Here, we present a case of CMSC in a 51-year-old woman who presented with a cystic mass localized in the left sole. She had no history of previous trauma or surgical procedures performed in the area. Although the case explained in this report is a spontaneous case of CMSC that occurred without a history of trauma, it is believed to have been caused by constant and chronic pressure since CMSC occurred in the first metatarsal head area, a part of the sole where heavy pressure is consistently applied.

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“…Synovial-like metaplasia associated with prostheses and breast implant capsules has also been reported and may occur in postsurgical cutaneous scars, which are unrelated to prostheses or implants [4-6]. …”

Section: Discussionmentioning

confidence: 99%

A hypothetical correlation between hyaluronic acid gel and development of cutaneous metaplastic synovial cyst

et al. 2010

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Thousands of patients receive hyaluronic acid filler injections, and the effects are generally considered acceptable. The acid rarely causes cutaneous reactions, which are only occasionally reported in the literature.The aim of the present work is to analyze a clinical case that has never been reported in the literature to our knowledge. This case is of a 26-year-old woman who presented with a cyst in the infrazygomatic region that was injected with non-animal stabilized hyaluronic acid at another centre a few months ago.Consequently, we made an external incision to remove the neoplasm: histological examination of the capsule revealed it to be a cutaneous metaplastic synovial cyst.

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Multiple cutaneous metaplastic synovial cysts

Cited by 25 publications

References 11 publications

Cutaneous Metaplastic Synovial Cyst: Case Report and Literature Review from the Dermatological Point of View

Cutaneous Metaplastic Synovial Cyst: Case Report and Literature Review from the Dermatological Point of View

Cutaneous Metaplastic Synovial Cyst of the First Metatarsal Head Area

A hypothetical correlation between hyaluronic acid gel and development of cutaneous metaplastic synovial cyst

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