Multiple cutaneous metastases of oesophageal squamous cell carcinoma that mimic keratoacanthoma

Aguiar, Herberti Rosique; Calderoni, Davi Reis; Stelini, Rafael Fantelli; Andreollo, N.A; Kharmandayan, Paulo

doi:10.1016/j.jpra.2015.10.002

Cited by 4 publications

(19 citation statements)

References 11 publications

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“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the primary site of malignancy, gastrointestinal (GI) tract accounted for 24.4% (30/123), breast for 17.9% (22/123) of cases, kidney for 8.1% (10/123), lung for 7.3% (9/123), thyroid for 7.3% (9/123), uterus for 6.5% (8/123), central nervous system (CNS) for 6.5% (8/123), liver for 3.3% (4/123) and other anatomic areas for 18.7% (23/123) of cases …”

Section: Resultsmentioning

confidence: 99%

“…Regarding the primary site of malignancy, gastrointestinal (GI) tract accounted for 24.4% (30/123), 2,14,16,23,30,32,33,36,46,48,49,56,61,63,64,71,78,79,83,84,88,93,96,98,101,102,105,106,115,118 breast for 17.9% (22/123) of cases, 4,6,7,10,11,13,15,[17][18][19]26,27,29,34,35,37,44,66,67 kidney for 8.1% (10/123), lung for 7.3% (9/ 123), 25,38,43,<...>…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

“…Median time between primary tumour and AN diagnosis was 10 months (ranging from 0 to 240 months; IQR: 0-36). Finally, AN was the first metastatic event in 65 cases, 6,9,11,12,16,17,[19][20][21][22]24,28,34,36,37,39,41,51,54,56,60,62,67,70,72,[74][75][76][77]79,80,84,86,92,93,109,115,[117][118][119]121 with a median number of 1 lesion (ranging from 1 to 8) and a median diameter of 3 cm (ranging from 1 to 20 cm; IQR:1.5-4.7).…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

“…10,30,37,44,52,56,66,77 When reported, AN was asymptomatic in the majority of cases (78%; 21/27), with pain being reported in 22% of cases (6/27 cases). 21,32,42,56,69,117 According to the site on the scalp, in the majority of cases (70/94) only one site was involved, being the parietal area the most frequently reported with 19 cases, 30,31,33,35,45,48,50,55,69,78,[92][93][94][95]104,106,107,110,116 followed by the frontal with 18 cases, 2,[7][8][9]16,38,42,44,52,65,[80][81][82]98,114,[117][118]…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

See 4 more Smart Citations

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression‐free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

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“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

See 3 more Smart Citations

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Cutaneous metastases: A great imitator

Jaros

Hunt

Mose

et al. 2020

Clinics in Dermatology

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Diagnosis and Management of Scalp Metastases: A Review

Cedirian,

Rapparini,

Sechi

et al. 2024

Diagnostics

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Scalp metastases (SMs) are particularly noteworthy, representing around 4–7% of cutaneous neoplasms in this region of the body, possibly due to its rich blood supply. Diagnosis of SMs involves a systematic approach encompassing oncologic history, clinical examination, dermoscopy, imaging, and histopathological assessment. Clinical presentations of SM can vary, but dermoscopy reveals unique vascular patterns aiding in diagnosis. Imaging, particularly MRI and CT, and histopathological evaluation are mandatory for definitive diagnosis. Treatment strategies vary depending on tumor characteristics and staging, ranging from surgical excision to systemic therapies like chemotherapy or radiotherapy. Multimodal approaches tailored to individual cases yield optimal outcomes. The diagnostic tools available do not always allow SMs to be diagnosed, and often the lack of knowledge on the part of oncologists in suspecting SMs can delay an early diagnosis. This review provides clinicians with a practical guide for the timely diagnosis and management of SM, emphasizing the importance of a multidisciplinary approach and personalized treatment strategies for improved patient outcomes.

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Multiple cutaneous metastases of oesophageal squamous cell carcinoma that mimic keratoacanthoma

Cited by 4 publications

References 11 publications

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Cutaneous metastases: A great imitator

Diagnosis and Management of Scalp Metastases: A Review

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