Multiple Cutaneous Metastasis from Carcinoma of the Penis—Report of Two Cases

Purkayastha, Joydeep

doi:10.1007/s13193-012-0195-6

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…It was reported simultaneously with the primary disease 8 and also after nine months of treatment of primary disease. 9 In our patient, cutaneous metastases were localized to inguinal and pubic area as nodulo-ulcerative lesions but the primary malignancy of the penis was hidden due to a buried penis. Another presentation of cutaneous metastasis of penile SCC was carcinoma en cuirasse.…”

Section: Discussionmentioning

confidence: 59%

Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations

2019

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The incidence of penile squamous cell carcinoma (SCC) varies widely in different parts of the world. It is rare in Western countries but common in developing countries like India. The glans and foreskin are the most commonly affected sites. It can occur in two forms which have different evolution and prognosis. Exophytic papillary lesions have late and rare lymphatic spread and ulcero-infiltrating lesions are associated with rapid lymph node invasion and a poorer prognosis. Human immunodeficiency virus (HIV) is an aggravating factor for penile cancer and accelerates the progression of the disease. Cutaneous metastasis from penile SCC is rarely reported. Here, we report a case of metastatic SCC of the penis in a 51-year-old HIV-infected man who presented with cutaneous metastases in the inguino-pubic region with a hidden penile SCC.

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Section: Discussionmentioning

confidence: 59%

Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations

2019

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Section: Discussionmentioning

confidence: 99%

“…The presence of lymph node metastasis in the inguinal and iliac regions increased the risk of death, which is the most common metastatic event [ 50 ] and the main prognostic marker [ 51 ]. Systemic metastases are rarely reported [ 41 , 50 ] and locoregional recurrences are also less frequent [ 52 ], but these two parameters were associated with an increased risk of death by 4.3 and 5.5-fold, respectively. Penectomy is still a widely used treatment for extensive lesions or tumors involving the base and the bulbar urethral part of the penis [ 13 , 41 , 53 ], but our results indicate that this type of surgery was not linked to survival rate.…”

Section: Discussionmentioning

confidence: 99%

HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics

et al. 2022

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Background Penile cancer is one of the most aggressive male tumors. Although it is preventable, the main etiologic causes are lifestyle behaviors and viral infection, such as human papillomavirus (HPV). Long-term epigenetic changes due to environmental factors change cell fate and promote carcinogenesis, being an important marker of prognosis. We evaluated epidemiological aspects of penile squamous cell carcinoma (SCC) and the prevalence of HPV infection using high-risk HPV (hrHPV) and p16INK4A expression of 224 participants. Global DNA methylation was evaluated through 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Results The incidence of HPV was 53.2% for hrHPV and 22.32% for p16INK4a. hrHPV was not related to systemic or lymph node metastasis and locoregional recurrence, nor influenced the survival rate. P16INK4a seems to be a protective factor for death, which does not affect metastasis or tumor recurrence. Lymph node and systemic metastases and locoregional recurrence increase the risk of death. An increased 5mC mark was observed in penile SCC regardless of HPV infection. However, there is a reduction of the 5hmC mark for p16INK4a + (P = 0.024). Increased 5mC/5hmC ratio (> 1) was observed in 94.2% of penile SCC, irrespective of HPV infection. Despite the increase in 5mC, it seems not to affect the survival rate (HR = 1.06; 95% CI 0.33–3.38). Conclusions P16INK4a seems to be a good prognosis marker for penile SCC and the increase in 5mC, an epigenetic mark of genomic stability, may support tumor progression leading to poor prognosis.

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“…Thirteen per cent of patients had skin metastasis, previously only described in case reports. 9 Most patients received penile surgery prior to or during metastatic recurrence, with those relapsing after 12 months achieving better outcomes than those relapsing earlier. Our data show a statistically significant difference between BSC and first-line chemotherapy outcomes, supporting the use of chemotherapy in fit mpSCC patients.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal cohort analysis of patients with metastatic penile cancer treated in a large quaternary academic centre

Liu

Patel

Crawford

et al. 2021

Journal of Clinical Urology

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Objective: This study aimed to provide real-world data on the multidisciplinary management of metastatic penile squamous-cell carcinoma (mpSCC) patients and their survival outcomes, particularly those who receive best supportive care (BSC). Methods: A retrospective analysis of 1720 patients, managed via a supra-regional penile-specialist multidisciplinary team was conducted between January 2006 and May 2020. Results: A total of 101 patients (median age 63 years; interquartile range 56–72 years; 73% ECOG 0/1) were included. Of these, 32% (32/101) had previously received adjuvant chemotherapy prior to metastatic recurrence, 58% (59/101) received chemotherapy and 42% (42/101) received BSC. Further, 17% (17/101) received second-line systemic therapy, and 3% (3/101) received third-line systemic therapy. For first-line systemic-therapy, there was a 46% (27/59) clinical benefit rate (CBR), with 9% (5/59) complete response, 15% (9/59) partial response and 22% (13/59) stable disease. Patients receiving second-line therapy ( n=17) had a 29% (5/17) CBR. Median progression-free survival for first- and second-line treatment was 3.2 and 2.2 months, respectively. Median overall survival (mOS) for all patients was 6.2 months. mOS for first-line chemotherapy, second-line chemotherapy and BSC patients was 7.2, 4.5 and 2.0 months, respectively. Conclusions: First-line platinum-based chemotherapy is associated with notable response rates in mpSCC patients. Agents with better response rates are needed urgently potentially in combination with platinum-based chemotherapy. Level of evidence: Level 2b.

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Multiple Cutaneous Metastasis from Carcinoma of the Penis—Report of Two Cases

Cited by 3 publications

References 8 publications

Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations

Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations

HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics

Longitudinal cohort analysis of patients with metastatic penile cancer treated in a large quaternary academic centre

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