Multiple drug resistance of Listeria monocytogenes isolated from aborted women by using serological and molecular techniques in Diwaniyah city/ Iraq

Al-Mayahi, Firas S. Abd; Jaber, Saja Mahdey

doi:10.18502/ijm.v12i4.3933

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…L. monocytogenes has been found to be a highly occurring pathogen in several countries, including the United States, United Kingdom, Australia, Canada, and Mexico [11]. It is found in the environment and is carried by animals [12]. Humans are infected with the bacteria primarily by eating or handling contaminated food or touching contaminated surfaces [12].…”

Section: Introductionmentioning

confidence: 99%

“…It is found in the environment and is carried by animals [12]. Humans are infected with the bacteria primarily by eating or handling contaminated food or touching contaminated surfaces [12]. It can also be transmitted from mother to child in utero or at birth [12].…”

Section: Introductionmentioning

confidence: 99%

“…Humans are infected with the bacteria primarily by eating or handling contaminated food or touching contaminated surfaces [12]. It can also be transmitted from mother to child in utero or at birth [12]. L. monocytogenes is susceptible to a wide range of antibiotics active against Gram-positive bacteria, except cephalosporins and fosfomycin, for which it has inherent resistance [13].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Antimicrobial Resistance Genes in Listeria monocytogenes from 2010 through to 2021

Hanes

Huang

2022

IJERPH

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Antimicrobial resistance (AMR) is a serious public health issue. Due to resistance to current antibiotics and a low rate of development of new classes of antimicrobials, AMR is a leading cause of death worldwide. Listeria monocytogenes is a deadly foodborne pathogen that causes listeriosis for the immunocompromised, the elderly, and pregnant women. Unfortunately, antimicrobial resistance has been reported in L. monocytogenes. This study conducted the first comprehensive statistical analysis of L. monocytogenes isolate data from the National Pathogen Detection Isolate Browser (NPDIB) to identify the trends for AMR genes in L. monocytogenes. Principal component analysis was firstly used to project the multi-dimensional data into two dimensions. Hierarchical clustering was then used to identify the significant AMR genes found in L. monocytogenes samples and to assess changes during the period from 2010 through to 2021. Statistical analysis of the data identified fosX, lin, abc-f, and tet(M) as the four most common AMR genes found in L. monocytogenes. It was determined that there was no increase in AMR genes during the studied time period. It was also observed that the number of isolates decreased from 2016 to 2020. This study establishes a baseline for the ongoing monitoring of L. monocytogenes for AMR genes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of Antimicrobial Resistance Genes in Listeria monocytogenes from 2010 through to 2021

Hanes

Huang

2022

IJERPH

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“…The emergence of multi drug-resistant Candida albicans is prevalent among pregnant and non-pregnant women with vaginitis [ 299 ]. Listeria monocytogenes from patients with spontaneous abortions [ 310 ] and multidrug-resistant clinical Enterococcus faecalis from pregnant women [ 292 ] highlight the need for more precautions and constant monitoring, with the appropriate identification of MDR and susceptibility tests prior to medication. The development of a candidate vaccine and the early diagnosis of MDR infection shall be a better option for protection against MDR infection.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

Borgio

Rasdan

Sonbol

et al. 2021

Biology

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We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, published during the last 10 years, were retrieved from PubMed and Scopus. A total of 382 studies were included as per the inclusion and exclusion criteria, as well as the PRISMA guidelines, from a thorough screening of 1705 articles, in order to analyse the emerging status and mortality. The emerging nature of >120 multidrug-resistant (MDR) bacteria and fungi in the Arabian Peninsula is a serious concern that requires continuous monitoring and immediate preventive measures. More than 50% (n = 453) of multidrug-resistant, microbe-associated mortality (n = 871) in the Arabian Peninsula was due to MDR Acinetobacter baumannii, Mycobacterium tuberculosis and Staphylococcus aureus infection. Overall, a 16.51% mortality was reported among MDR-infected patients in the Arabian Peninsula from the 382 articles of this registered systematic review. MDR A. baumannii (5600 isolates) prevailed in all the nine countries of the Arabian Peninsula and was one of the fastest emerging MDR bacteria with the highest mortality (n = 210). A total of 13,087 Mycobacterium tuberculosis isolates were reported in the region. Candida auris (580 strains) is the most prevalent among the MDR fungal pathogen in the Arabian Peninsula, having caused 54 mortalities. Active surveillance, constant monitoring, the development of a candidate vaccine, an early diagnosis of MDR infection, the elimination of multidrug resistance modulators and uninterrupted preventive measures with enhanced data sharing are mandatory to control MDR infection and associated diseases of the Arabian Peninsula. Accurate and rapid detection methods are needed to differentiate MDR strain from other strains of the species. This review summarises the logical relation, prevalence, emerging status and associated mortality of MDR microbes in the Arabian Peninsula.

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“…It is reported as a prevalent pathogen across various countries, such as the United Kingdom, the United States, Canada, Australia, and Mexico [ 6 ]. L. monocytogenes is commonly found in environmental settings and is carried by animals, with humans primarily contacting the bacteria through contaminated foods and surfaces [ 7 ]. Consequently, L. monocytogenes poses significant concerns for the food industry [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Druggability Analysis of Protein Targets for Drug Discovery to Combat Listeria monocytogenes

Hanes,

Liu,

Huang

2024

Microorganisms

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Extensive research has been conducted to identify key proteins governing stress responses, virulence, and antimicrobial resistance, as well as to elucidate their interactions within Listeria monocytogenes. While these proteins hold promise as potential targets for novel strategies to control L. monocytogenes, given their critical roles in regulating the pathogen’s metabolism, additional analysis is needed to further assess their druggability—the chance of being effectively bound by small-molecule inhibitors. In this work, 535 binding pockets of 46 protein targets for known drugs (mainly antimicrobials) were first analyzed to extract 13 structural features (e.g., hydrophobicity) in a ligand–protein docking platform called Molsoft ICM Pro. The extracted features were used as inputs to develop a logistic regression model to assess the druggability of protein binding pockets, with a value of one if ligands can bind to the protein pocket. The developed druggability model was then used to evaluate 23 key proteins from L. monocytogenes that have been identified in the literature. The following proteins are predicted to be high-potential druggable targets: GroEL, FliH/FliI complex, FliG, FlhB, FlgL, FlgK, InlA, MogR, and PrfA. These findings serve as an initial point for future research to identify specific compounds that can inhibit druggable target proteins and to design experimental work to confirm their effectiveness as drug targets.

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Multiple drug resistance of Listeria monocytogenes isolated from aborted women by using serological and molecular techniques in Diwaniyah city/ Iraq

Cited by 6 publications

References 24 publications

Investigation of Antimicrobial Resistance Genes in Listeria monocytogenes from 2010 through to 2021

Investigation of Antimicrobial Resistance Genes in Listeria monocytogenes from 2010 through to 2021

Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

Druggability Analysis of Protein Targets for Drug Discovery to Combat Listeria monocytogenes

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