Multiple endocrine neoplasia‐like syndrome in a horse

Germann, Sara; Rutten, Michael J.; Derungs, S.; Feige, Karsten

doi:10.1136/vr.159.16.530

Cited by 19 publications

(27 citation statements)

References 3 publications

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“…Eight horses in our study had pathologic findings consistent with MEN. This syndrome has been well described in humans and has been reported in horses . Multiple endocrine neoplasia is defined as simultaneous neoplasia and hyperplasia of multiple endocrine tissues.…”

Section: Discussionmentioning

confidence: 94%

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Clinical and Pathological Features of Pheochromocytoma in the Horse: A Multi‐Center Retrospective Study of 37 Cases (2007–2014)

Luethy

Habecker

Murphy

et al. 2015

Veterinary Internal Medicne

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BackgroundPheochromocytoma is the most common adrenal medullary neoplasm of domestic animals, but it is rare in horses. Antemortem diagnosis in horses is difficult, with clinical signs often being vague or non‐specific.ObjectiveThe objective of this study was to describe the clinical, laboratory, and pathologic findings of pheochromocytoma in horses.AnimalsThirty‐seven horses diagnosed with pheochromocytoma based on postmortem examination from 2007 to 2014.MethodsRetrospective case series.ResultsPheochromocytoma was identified in 37/4094 horses during postmortem examination. Clinical signs consistent with pheochromocytoma had been observed antemortem in only 7 cases, with the remainder being incidental findings. Colic was the most common presenting complaint (13 of 37 cases) and tachycardia was noted in 95% of cases (median heart rate of 86 bpm in clinical cases). Hyperlactatemia (median, 4.9 mmol/L) and hyperglycemia (median, 184 mg/dL) were the most common clinicopathologic abnormalities. Hemoperitoneum caused by rupture of pheochromocytoma was noted in 4/7 clinical cases. Concurrent endocrine abnormalities (eg, thyroid adenoma, adrenal hyperplasia, pituitary pars intermedia hyperplasia or adenoma, parathyroid C‐cell carcinoma) were found in 27/37 horses, with 8/37 horses having lesions consistent with multiple endocrine neoplasia syndrome as described in humans.ConclusionsPheochromocytoma was diagnosed in 0.95% of horses presented for necropsy. The majority of these were incidental findings, but pheochromocytoma was thought to contribute to clinical findings in 19% of cases, and multiple endocrine neoplasms were commonly seen. Usually an incidental finding at necropsy, pheochromocytoma may cause acute death from intraperitoneal exsanguination and should be considered in horses presenting with colic, tachycardia, and hemoperitoneum.

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Section: Discussionmentioning

confidence: 94%

“…Multiple endocrine neoplasia is defined as simultaneous neoplasia and hyperplasia of multiple endocrine tissues, and has been found to have a genetic basis in humans . Such a syndrome previously has been described in horses, cattle, dogs, cats, and humans …”

mentioning

confidence: 99%

Clinical and Pathological Features of Pheochromocytoma in the Horse: A Multi‐Center Retrospective Study of 37 Cases (2007–2014)

Luethy

Habecker

Murphy

et al. 2015

Veterinary Internal Medicne

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“…Most adrenal tumours in horses arise from the chromaffin cells of the medulla and are classified as unilateral benign pheochromocytomas (Germann et al . ; Luethy et al . ).…”

Section: Adrenal Glandsmentioning

confidence: 99%

“…Most of these tumours are silent (80%), with no clinical signs and incidentally diagnosed during post‐mortem examination (Germann et al . ; Luethy et al . ).…”

Section: Adrenal Glandsmentioning

confidence: 99%

Endocrine tumours in equids

Pérez-Écija

Toribio

Mendoza

2017

Equine Veterinary Education

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“…In Anbetracht dessen erschien es uns interessant, Daten bezüglich des normalen Ultraschallbildes und der sonographisch ermittelten, physiologischen Ausmaße der Nebenniere bei Trabern zu sammeln. Auf diese Weise könnten Dysplasien der Nebennieren im Verlauf endokriner Störungen aufgezeigt und gegebenenfalls Hinweise auf ein Phäochromozytom und das "Multiple endocrine neoplasia-like syndrome" in vivo gewonnen werden (Deftos und Nolan 1992, Breuer und Grabner et al 1993, Reef 1998, De Cock und MacLachlan 1999, Germann et al 2006.…”

Section: Introductionunclassified