2013
DOI: 10.1158/1541-7786.mcr-12-0501-t
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Multiple Functions of Sushi Domain Containing 2 (SUSD2) in Breast Tumorigenesis

Abstract: Routinely used therapies are not adequate to treat the heterogeneity of breast cancer, and consequently, more therapeutic targets are desperately needed. To identify novel targets, we generated a breast cancer cDNA library enriched for genes that encode membrane and secreted proteins. From this library we identified SUSD2 (Sushi Domain Containing 2), which encodes an 822 amino acid protein containing a transmembrane domain and functional domains inherent to adhesion molecules. Previous studies describe the mou… Show more

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Cited by 64 publications
(104 citation statements)
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“…Very little is known about this human receptor. It was indeed recently shown by mass spectrometry to interact with galectin-1, a protein extensively studied for its role in tumor immune-escape mechanisms and angiogenesis (43), and was even more recently isolated using a breast cancer cDNA library based approach (44). In this work, the authors show weak or no expression of SUSD2 in normal epithelial cells, but staining of lobular and ductal breast carcinomas, thereby confirming our findings on the expression of this protein.…”
Section: Selection For Cell Surface Binders On Breast Cancer Cellsupporting
confidence: 86%
“…Very little is known about this human receptor. It was indeed recently shown by mass spectrometry to interact with galectin-1, a protein extensively studied for its role in tumor immune-escape mechanisms and angiogenesis (43), and was even more recently isolated using a breast cancer cDNA library based approach (44). In this work, the authors show weak or no expression of SUSD2 in normal epithelial cells, but staining of lobular and ductal breast carcinomas, thereby confirming our findings on the expression of this protein.…”
Section: Selection For Cell Surface Binders On Breast Cancer Cellsupporting
confidence: 86%
“…Two previous studies (6,7) have been published describing the mouse homolog SUSD2 as a potential tumor suppressor. By contrast, Watson et al (5) reported that SUSD2 was overexpressed in breast cancer, and Table II. Association between SUSD2 expression and clinicopathological features of patients with non-small cell lung cancer.…”
Section: Discussionmentioning
confidence: 90%
“…indicated that SUSD2 enhanced the invasion of breast cancer cells. Accelerated tumor formation and decreased survival rates in mice with tumors expressing SUSD2 were observed in a syngeneic mouse model (5). However, the underlying physiopathological role of SUSD2 in human NSCLC has remained to be elucidated.…”
Section: Discussionmentioning
confidence: 99%
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