Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel

Abstract

Aim To determine allele frequencies and forensic statistics of 22 autosomal short tandem repeat loci in Chinese Mongolian population. Methods Blood specimens were collected from 134 unrelated healthy Mongolian individuals, and 22 short tandem repeat loci were co-amplified and genotyped. Allele frequencies and forensic parameters were calculated, and population genetic differences were analyzed among Mongolian population and other eight Chinese populations: Northern Han, Guangdong Han, Chengdu Han, Xinjiang Hui, Xinjiang Uygur, Hainan Li, Qinghai Tibetan, and Hainan Han. Results All the loci were in the Hardy-Weinberg equilibrium, and after Bonferroni correction there was no linkage disequilibrium between them. The allele frequencies of these 22 loci were between 0.0037 and 0.3657. This panel had high discriminating power and genetic polymorphism in the Mongolian population, with combined power of discrimination of 0.999999999999999999999999998399 and combined probability of exclusion of 0.9999999999566925. Structure analysis showed no evidence that these nine Chinese populations had different component distribution. However, genetic distance analysis showed significant differences among them ( P < 0.05). Conclusion The combined application of these 22 loci could be useful for forensic purposes in the Mongolian population. Mongolian population had smaller genetic distances from the populations in northern China (Northern Han, Xinjiang Uygur, and Xinjiang Hui) than from the populations in Hainan province (Hainan Han and Hainan Li populations).

RETRACTED: Forensic characteristics and genetic affinity analyses of Xinjiang Mongolian group using a novel six fluorescent dye‐labeled typing system including 41 Y‐STRs and 3 Y‐InDels

“…Up to the present, forensic scientists carried out many studies on the genetic polymorphisms of the Mongolian group. And these studies were based on different molecular genetic markers, such as autosomal STRs (Fang et al, 2019;Gao et al, 2014;Wen et al, 2019;Zha et al, 2014), X-Chromosome STR (Chen et al, 2018), Y-STR (Fu et al, 2016;Gao et al, 2016;Wang et al, 2019), human leukocyte antigen (Gu, Chen, Yao, Sun, & Shi, 2019;Hong et al, 2007), SNPs (Brissenden et al, 2015). These studies were of great reference values for the Mongolian group genetic research, while research on the Y-STR haplotype data in XJM group is still insufficient.…”

The Polymorphism Analyses of Short Tandem Repeats as a Basis for Understanding the Genetic Characteristics of the Guanzhong Han Population

“…In this research, the Microreader™ 23sp ID system was used to study the genetic polymorphisms of 22 autosome STR loci for the Han population in the Guanzhong region, and the effectiveness of this system was further verified. At the same time, 13 groups were selected as reference groups in this study based on 15 shared STR loci with the purpose of understanding the genetic relationships among the groups from China, including Xinjiang Hui [ 18 ], Northern Han [ 10 ], Southern Han [ 19 ], Chengdu Han [ 20 ], Xinjiang Uygur [ 21 ], Xinjiang Kazakh [ 22 ], Xinjiang Mongolian [ 23 ], Hainan Li [ 24 ], Zhejiang She [ 25 ], Guangdong Han [ 26 ], Hainan Han [ 27 ], Qinghai Tibetan [ 28 ], and Changsha Hui groups [ 29 ].…”

Genetic Polymorphisms and Forensic Efficiencies of a Set of Novel Autosomal InDel Markers in a Chinese Mongolian Group

“…e main religion of the Mongolian people is Buddhism (http://www.paulnoll.com/China/Minorities/ min-Mongolian.html). Nowadays, genetic analyses of the Chinese Mongolian group mainly focused on STR loci, such as 19 X-STR loci [9] and 19 autosomal STRs [10], 22 autosomal STR loci [11], 12 X-STR [12], and 27 Y-STR [13];…”