Multiple Granular Cell Tumors and Growth Hormone Deficiency in a Child

Abstract

Granular cell tumor is an uncommon benign tumor occurring on the skin as a single nodule. Multiple tumors are very rare, particularly in children. We describe a child with multiple granular cell tumors on the skin in association with growth hormone deficiency. The occurrence of multiple granular cell tumors in association with other clinical manifestations in childhood is discussed.

Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11

“…Of note, the daughter also had MGCT. These included lentiginosis (29,30,31), cryptorchidism and ptosis (32), pulmonary stenosis and small joint hyperextensibility (33), hypertelorism and small joint hyperextensibility (26), and short stature (27,34,35). However, the constitutional molecular lesion in these patients was not defined.…”

Multiple granular cell tumors in a child with growth retardation. Report of a case and review of the literature

“…The first in a 7‐year‐old boy with three cutaneous GCTs and coincidental growth retardation of unexplained cause 26 . Multiple GCTs were subsequently described in a 10‐year‐old girl with primary pituitary insufficiency of growth hormone 27 . There are multiple reports in the literature of GCTs arising in the pituitary gland, but all cases reported to date have been in adults, and have therefore not been associated with short stature.…”

Multiple cutaneous granular cell tumors, joint hypermobility and mild facial dysmorphism in a child

“…In the literature, more than 30 cases of MGCT in children have been described; until 1990, 31 cases had been reported 9,11,15–17 and since then five additional cases have been reported 18–21,25 . Of these 36 cases, 13 (36%) presented an association with somatic defects (Table 1), which could involve various organs: the skin, the cardiovascular system, the musculoskeletal tissues and the nerve tissues.…”