Multiple Hormones in a Bronchial Tumor

Rees, Lesley; Bloomfield, Glenys A.; Rees, Gareth; Corrin, B.; Franks, L. M.; Ratcliffe, John G.

doi:10.1210/jcem-38-6-1090

Cited by 86 publications

(24 citation statements)

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“…Other postulated mechanisms, which lack substantial experimental support, include secretion of insulin releasing material by normal beta cells, inhibition of insulinase, secretion of hypoglycaemia-producing metabolites of tryptophan and impairment of hepatic glucose-6-phosphatase. (1973) Immunoreactive insulin has also been found in two tumours, both in the lung, not associated with symptomatic hypoglycaemia (Unger et al, 1964;Rees et al, 1974). …”

Section: E C T O P I C I N S U L I Nmentioning

confidence: 99%

“…These reported associations may well reflect the interest and technical facilities available to the investigator as well as the problems of clinical recognition of one hormone in the presence of another. Recently we have studied the hormone content of an oat cell carcinoma of the lung associated with the ectopic ACTH syndrome in which significant amounts of eight peptides were found : ACTH, MSH, CLIP, AVP, oxytocin, neurophysin, insulin and prolactin (Rees et al, 1974). The pattern of multiple ectopic hormone production or release may alter during the course of the disease; thus, whereas the surgical specimen of the primary neoplasm contained high concentrations of AVP, oxytocin and neurophysin but low prolactin levels, the reverse occurred in the liver metastasis.…”

Section: U L T I P L E E C T O P I C H O R M O N E S E C R E T I O Nmentioning

confidence: 99%

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Ectopic Hormone Production by Non‐endocrine Tumours

Rees

Ratcliffe

1974

Clinical Endocrinology

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151

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The recognition that certain clinical syndromes are due to secretion of hormones by 'non endocrine' tumours, has been among the major developments in endocrinology in the last decade and has forged a new link with oncology. The phenomenon has general clinical and biochemical implications. Clinicians now recognize that the accompanying metabolic derangements may be more malign than the neoplasm itself, may significantly affect prognosis, and they use the measurement of plasma hormone levels and related substances for diagnosis and management. From the biochemical point of view, the study of ectopic hormone secretion provides new insight into the state of tissue differentiation. It serves as an excellent model for the broader field of inappropriate tumour products, since the structure of most hormones is known and because recent technical advances have improved methods for their purification and assay. Several reviews have discussed the clinical aspects of ectopic humoral syndromes (Bower

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Section: E C T O P I C I N S U L I Nmentioning

confidence: 99%

Section: U L T I P L E E C T O P I C H O R M O N E S E C R E T I O Nmentioning

confidence: 99%

Ectopic Hormone Production by Non‐endocrine Tumours

Rees

Ratcliffe

1974

Clinical Endocrinology

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151

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“…Carcinoids arising from the gastrointestinal tract were mainly found in duodenum and jejunum. Pancreatic endocrine tumors were the second most common cause of ectopic GHRH production arising from the tail of the pancreas and these tumors are not normally aggressive in nature [114][115]. Not all patients exhibit the acromegalic feature despite the fact that 30-60% of tumor cells of pancreatic endocrine tumors stained positive for GHRH.…”

Section: /12mentioning

confidence: 99%

“…Historical Perspective: First suggestion of ectopic production of PRL was by Rees et al [115] in 1974, where a bronchial tumor was found to be actually producing the PRL hormone. Later, in 1986, a case of long standing gynecomastia associated with a hypernephroma, was reported in literature where serum PRL returned to normal after radical nephrectomy and remained so for 4 years without evidence of tumor recurrence [119].…”

Section: Ectopic Prolactin (Prl) Production By Tumorsmentioning

confidence: 99%

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Endocrine Paraneoplastic Syndromes: A Review

Arabi¹

2015

EMIJ

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It is important for the endocrinologist and oncologist to recognize these paraneoplastic endocrine syndromes since this may help in defining the cancer type and hence lead to the appropriate management. In addition, these syndromes are a major cause of morbidity and mortality. Moreover, AbstractParaneoplastic endocrine syndromes result from ectopic production of hormones by different tumors. Hypercalcemia of malignancy is the most common, mostly caused by ectopic parathyroid hormone related peptide (PTHrP) production which increases bone resorption. Other causes include the rare ectopic parathyroid hormone (PTH) production, ectopic production of 1, 25-(OH)2 vitamin D by the tumor and its adjacent macrophages and bone metastasis which by itself in addition to the local production of PTHrP at the level of the bone lead to bone resorption and thus hypercalcemia. Treatment includes extracellular fluid volume repletion, bisphosphonates or denosumab and calcitonin. Ectopic Cushing's syndrome caused by ectopic ACTH production results in hypokalemia, proximal muscle weakness, easy bruisability, hypertension, diabetes and psychiatric abnormalities including depression and mood disorders. Different diagnostic measures help to differentiate Cushing's disease from ectopic Cushing's syndrome. Treatment includes surgical resection of tumor and medical therapy to suppress excess cortisol production. Ectopic secretion of ADH has been associated with different tumor types. The best treatment options include removal of the underlying tumor, chemotherapy, or radiotherapy in addition to free water restriction, demeclocycline and vaptans. Ectopic growth hormone releasing hormone secretion has been identified with carcinoids, phechromocytoma and other tumors. Surgery is the mainstay of therapy with systemic therapy used in metastatic disease. Other rare ectopic hormone syndromes have also been identified including ectopic prolactin, ectopic erythropoietin, and thrombopoetin in addition to others. Keywords 2/12paraneoplastic endocrine syndromes may be the first presenting feature of malignancy [2,3]. This paper provides an overview on the common PNES, their prevalence, diagnosis, prognosis and response to treatment (Table 1). Methodology of Literature SearchEligible studies were identified by a search, from year 1920 up till February 2014, in Medline, PUBMED and EMBASE using a refined search strategy with several terms used including "endocrine paraneoplastic syndromes", "ectopic hormones", "humoral hypercalcemia of malignancy", "ectopic parathyroid hormone related peptide", "ectopic ACTH", "ectopic Cushing syndrome", "ectopic antidiuretic hormone", "syndrome of inappropriate ADH", "ectopic growth hormone releasing hormone", "ectopic growth hormone", "ectopic prolactin", "ectopic thyroid stimulating hormone" in addition to several others. In addition, searches of personal collections and the reference lists of eligible studies were identified with their full text papers being retrieved. A-Hypercalcemia of MalignancyHistorical Perspec...

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Pituitary Pigmentary Hormones

Brown¹

1978

JAMA

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Pituitary control of pigmentation has known for more than 60 years. Since 1969, beta-melanocyte-stimulating hormone (beta-MSH) has been accepted as the main pituitary pigmentary hormone in man. Its "constant companionship" with adrenocorticotrophic hormone (ACTH) has also been repeatedly demonstrated. Current investigations challenge both of these concepts. Human beta-MSH immunoreactivity has been shown to be actually due to beta-lipotropic hormone (beta-LPH), a larger molecule that within itself contains the entire amino acid sequence of beta-MSH. Human beta-MSH does not exist in vivo; it is merely an extraction artifact formed by enzymatic degradation of beta-LPH. It would appear likely that beta-LPH, not beta-MSH, is the constant companion of ACTH.

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Multiple Hormones in a Bronchial Tumor

Cited by 86 publications

References 0 publications

Ectopic Hormone Production by Non‐endocrine Tumours

Ectopic Hormone Production by Non‐endocrine Tumours

Endocrine Paraneoplastic Syndromes: A Review

Pituitary Pigmentary Hormones

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