Multiple ileal neuroendocrine tumors (NETs) with cardiac metastasis and ectopic ileal pancreas

Coulier, B; Gielen, Isabelle; Colin, G.; Pierard, Frédéric; Floris, N; Richelle, Fabienne

doi:10.1016/j.diii.2018.04.010

Cited by 2 publications

(3 citation statements)

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“…Treatment included a somatostatin analog, but we have no information on the patient's subsequent fate. 27 Kawano and colleagues in turn described the case of a 78-year-old man with a cardiac nodular lesion, treated 10 years earlier for thymic carcinoma. Histopathologic examination revealed the lesion to be a metastatic carcinoid tumor.…”

Section: Tumors Of the Endocrine Systemmentioning

confidence: 99%

“…Also described is the case of a 43-year-old man with multiple foci of NETs located in the ileum, mesenteric lymph nodes, and the interventricular septum of the heart. Treatment included a somatostatin analog, but we have no information on the patient’s subsequent fate 27. Kawano and colleagues in turn described the case of a 78-year-old man with a cardiac nodular lesion, treated 10 years earlier for thymic carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Metastatic Tumors

Kopcik

Kościelecka

Krzyżak

2023

American Journal of Clinical Oncology

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Cardiac tumors are a heterogeneous group of pathologic masses of the heart that contain primary tumors—benign or malignant, and secondary tumors. Metastases are significantly more frequent, mostly originating from lung, breast, gastrointestinal tract, or ovary carcinomas. Secondary cardiac tumors may be asymptomatic or may cause cardiovascular, systemic, or embolic symptoms. The study is a summary of the available knowledge on cancerous metastatic lesions of the heart. Pleural mesothelioma (48.4%), adenocarcinoma (19.5%), or squamous cell carcinoma (18.2%) of lung, breast carcinoma (15.5%), ovarian carcinoma (10.3%), and bronchoalveolar carcinomas (9.8%) are cited as the most common origin of secondary heart tumors. Masses can spread by direct tumor invasion, by lymphatic vessels, veins, or arteries. Patients with cancer and nonspecific cardiovascular symptoms should be particularly vigilant, and the possibility of metastasis in an unusual location such as the myocardium should be considered in the diagnosis. Diagnostic methods include echocardiography, cardiac magnetic resonance, computed tomography, positron emission tomography, and histologic evaluation. Treatment of choice is managing primary carcinoma, due to the poor outcomes of surgical methods.

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Section: Tumors Of the Endocrine Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac Metastatic Tumors

Kopcik

Kościelecka

Krzyżak

2023

American Journal of Clinical Oncology

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“…Cardiac metastases can arise in the myocardium of any heart chamber, septa, or pericardium. 40 cases of cardiac NET metastases from midgut origin (the most common primary site for NET), have been reported to-date and this number will likely increase as more NET patients undergo routine imaging with gallium-68 dotatate (ga-68) PET/CT [3,4,5] . The Ga-68 tracer binds to somatostatin receptor 2 (SSTR2) with greater avidity than the 111In pentetreotide tracer (used for octreotide scans) and is more sensitive for detecting bony and visceral lesions [6] .…”

Section: Introductionmentioning

confidence: 99%

Hidden Figures: Occult Intra-Cardiac Metastases in Asymptomatic Neuroendocrine Tumor Patients

Das

Pineda

Berlin

et al. 2018

JOCR

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Carcinoid heart disease is a devastating paraneoplastic consequence of unchecked hormone production from neuroendocrine tumors (NET) and often results in right-sided heart failure. While it occurs frequently in NET patients with carcinoid syndrome, cardiac metastases occur much less often and are usually only incidentally found. Gallium-68 dotatate (ga-68) is an imaging tracer which binds to somatostatin receptor 2 with greater avidity than Indium-111, the tracer used commonly in octreotide scans. Ga-68 PET/CT is the most sensitive study for detecting occult NET metastases and has emerged as the current imaging gold standard. We describe two cases from Vanderbilt University Medical Center and Stanford University Medical Center where asymptomatic patients with well-differentiated midgut NET were diagnosed with intra-cardiac metastases using ga-68 PET/CT. Management of these patients was altered based on the findings as they underwent extensive cardiac evaluation and initiation of therapy with octreotide. Fortunately, they have not suffered life-threatening cardiac complications seen in some NET patients, from other published series, such as bradycardia, heart block, syncope and arrhythmias. These possibilities suggest early cardiology evaluation and consideration of other therapies beyond octreotide, such as surgery or PRRT, may be essential for all NET patients found to have intra-cardiac metastases.

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Multiple ileal neuroendocrine tumors (NETs) with cardiac metastasis and ectopic ileal pancreas

Cited by 2 publications

References 4 publications

Cardiac Metastatic Tumors

Cardiac Metastatic Tumors

Hidden Figures: Occult Intra-Cardiac Metastases in Asymptomatic Neuroendocrine Tumor Patients

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