“…the production of melanin in melanocytes [Kaufmann et al, 1991;De Schepper et al, 2005], of osteopontin in osteoblasts [Li et al, 2009], of FGF-2, PDGF and midkine in Schwann cells [Mashour et al, 2001], or of collagen in fibroblasts [Yang et al, 2006]. Some NF1 +/-cells display more variable sizes and shapes than their NF1 +/+ counterparts, when they are cultured on surfaces with high stiffness such as Schwann cells [Rosenbaum et al, 2000], keratinocytes [Koivunen et al, 2000;Korkiamäki et al, 2002] or osteoclasts [Heervä et al, 2010;Stevenson et al, 2011]. Several findings demonstrate alterations in the cytoskeletal organization by NF1 haploinsufficiency.…”