Control technology for engines and/or powertrains is becoming increasingly important for achieving higher energy efficiency and lower CO2 emissions in the real world in terms of the carbon neutrality of automobiles. CO2 emissions can be reduced using advanced combustion technologies and/or powertrain systems including hybrid powertrains. Such advanced combustion technologies show low robustness to changes in operation conditions, and advanced powertrain systems are difficult to optimize for complicated systems and uncertainty in the real road driving. Therefore, control technology is essential for taking full advantage of such hardware capabilities. Furthermore, the effective use of various information that is currently available, such as that on traffic signals, maps, and other cars, could lead to further reductions in CO2 emissions and energy consumption. This review summarizes the research on control technology, especially for advanced combustion and powertrain systems, and discusses the role of powertrain control and its future prospects.