Multiple intestinal perforation in a patient with Wegener's granulomatosis: A case report and review of the literature

Demiray, Emine Kübra Dindar; Koçak, Erdem; Yıldız, Pelin; Yıldız, Mustafa; Karakayali, Ahmet Sevki; Kaptanoğlu, Buğra; Köklü, Seyfettin

doi:10.1016/j.gcb.2010.08.009

Cited by 19 publications

(13 citation statements)

References 16 publications

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“…The gastrointestinal involvement in WG was reported very rarely [17, 18] and occasionally complicated by intestinal perforation [19, 20]. However, the clinical picture in the presence of gastrointestinal involvement is always dominated by the symptoms due to respiratory and renal involvement.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

Saadah

Al-Mughales

2013

Clinical and Developmental Immunology

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Background. It is unusual for the antineutrophil cytoplasmic antibody with cytoplasmic pattern (cANCA) to present in patients with inflammatory bowel disease (IBD) without vasculitis. The purpose of this study was to describe the occurrence and characteristics of pediatrics IBD with cANCA. Methods. A retrospective review of pediatric IBD associated with cANCA serology in patients from King Abdulaziz University Hospital, Saudi Arabia, between September 2002 and February 2012. Results. Out of 131 patients with IBD screened for cANCAs, cANCA was positive in 7 (5.3%) patients of whom 4 had ulcerative colitis and 3 had Crohn's disease. The median age was 8.8 years (2–14.8 years). Six (86%) were males. Of the 7 patients, 5 (71%) were Saudi Arabians and 2 were of Indian ethnicity. The most common symptoms were diarrhea, abdominal pain, weight loss, and rectal bleeding. None had family history or clinical features suggestive of vasculitis involving renal and respiratory systems. No difference in the disease location or severity was observed between cANCA positive and cANCA negative patients apart from male preponderance in cANCA positive patients. Conclusion. The occurrence of cANCA in pediatric IBD is rare. Apart from male preponderance, there were no peculiar characteristics for the cANCA positive patients.

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Section: Discussionmentioning

confidence: 99%

Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

Saadah

Al-Mughales

2013

Clinical and Developmental Immunology

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“…Notwithstanding, mortality is still higher than in the general population and some patients have relapsing disease and a poor prognosis. [8][9][10][11][12][13][14] Several studies about treatment with rituximab in GPA exist in the current literature. The symptoms and signs of systemic vasculitis involving the gastrointestinal (GI) tract mostly result from mesenteric ischemia.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal involvement in granulomatosis with polyangiitis and microscopic polyangiitis: histological features and outcome

et al. 2013

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“…First, PG-like ulcerations can occur with GPA and can often lead to misdiagnosis. [17][18][19][20][21] The diagnosis of inflammatory bowel disease in our patient is not entirely clear from the review of multiple biopsies performed elsewhere. Second, PG-like ulcerations can occur in atypical areas, such as the ear.…”

Section: Discussionmentioning

confidence: 99%

Granulomatosis with polyangiitis mimicking classic inflammatory bowel disease-associated pyoderma gangrenosum

et al. 2016

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Multiple intestinal perforation in a patient with Wegener's granulomatosis: A case report and review of the literature

Cited by 19 publications

References 16 publications

Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

Gastrointestinal involvement in granulomatosis with polyangiitis and microscopic polyangiitis: histological features and outcome

Granulomatosis with polyangiitis mimicking classic inflammatory bowel disease-associated pyoderma gangrenosum

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